Messenger RNA (mRNA) News and Research

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A new source of islet cells

The shortage of islet cells limits the development of islet transplantation. One new approach was reported in the October 21 issue of the World Journal of Gastroenterology because of its great significance in enhancing the output of islet cells.

25 Oct 2007

Illumina launches MicroRNA assay for gene expression profiling

Illumina, Inc. today launched a MicroRNA Assay for Gene Expression profiling. Priced at $95 per sample, this assay is the only solution available to allow rapid and reproducible miRNA expression profiling at a price less than half that of other commercially available methods.

From Illumina, Inc. 22 Oct 2007

Liver fibrosis will be treated by a potential target

The outcome of hepatitis is either self recovery or its development into liver fibrosis or, further, liver cirrhosis.

17 Oct 2007

RNA-binding protein key to understanding myotonic dystrophy type 1

Increased levels of a protein called CUGBP1 play an important role in the adult-onset form of muscular dystrophy called myotonic dystrophy type 1, said Baylor College of Medicine researchers in a report that appears in the journal Molecular Cell.

12 Oct 2007

Isis Pharmaceuticals awarded $1.5 million NIH grant to improve RNAi-based therapeutics

Isis Pharmaceuticals, Inc. has announced that it has been awarded a multi-year Phase 2 Small Business Innovation Research (SBIR) grant by the National Institutes of Health (NIH) for up to $1.5 million to design oligonucleotide drugs that can exploit the RNA interference (RNAi) antisense mechanism for disease treatment.

4 Oct 2007

Tumor cell receptor provides new therapeutic target

Working with a line of highly metastatic head and neck cancer cells, a research team at the Winship Cancer Institute and Emory University School of Medicine has found that a specific cell surface receptor present at very low levels in non-metastatic head and neck cancer cells.

27 Sep 2007

The jury is in: microRNAs can cause tumors to metastasize

These tiny molecules fine-tune protein production and play a powerful role in biological processes ranging from development to aging. Now scientists have proved that they can prompt otherwise sedentary cancer cells to move and invade other tissues.

27 Sep 2007

Space flight makes bacteria more infectious

Space flight has been shown to have a profound impact on human physiology as the body adapts to zero gravity environments.

25 Sep 2007

Test for lung cancer looks for discomforting quiet among protective genes

When it is quiet – "almost too quiet" – in movies, it is a sign that something is about to go wrong for the good guys.

18 Sep 2007

Mechanism for the in-vivo transport of siRNA

It all started with flowers: in the nineties of the last century Norwegian researchers discovered that additional copies of a particular gene in petunias inhibited its activity instead of reinforcing it as had been assumed.

18 Sep 2007

Powerful new discovery method speeds up gene discovery

Scientists will be able to pinpoint genetic causes of human diseases faster than ever thanks to a powerful new discovery method unveiled by the Southwest Foundation for Biomedical Research (SFBR) and an international team of researchers.

17 Sep 2007

Bad news for disease-causing bacteria!

Scientists have what could be some very bad news for disease-causing bacteria. All three major classes of antibiotics that kill infectious bacteria do so in part by ramping up the production of harmful free radicals, researchers report in the September 7, 2007, issue of Cell, a publication of Cell Press.

10 Sep 2007

1,000 strains of mice that feature the genetic diversity of the world population

Mice that are part of the Collaborative Cross project at Oak Ridge National Laboratory are helping scientists around the world learn more about possible causes of drug abuse, diabetes, sleep disorders, stress and pain, kidney disease and a number of other conditions that affect millions of people.

30 Aug 2007

New understanding of factor YY1 in gene expression

The Conaway Lab - led by Joan Conaway, Ph.D., and Ron Conaway, Ph.D., Investigators - has published findings that shed light on the role of the much-studied transcription factor YY1 in gene expression.

28 Aug 2007

Brain function is even more impaired in cirrhotic than non-cirrhotic alcoholics

Sustained exposure to alcohol can cause scarring and dysfunction of the liver, referred to as cirrhosis.

28 Aug 2007

In the junk lies treasure when it comes to DNA

Three micro RNA genes appear to be key partners of protective gene p53; their loss is linked to common type of lung cancer

24 Aug 2007

Proteins involved in fragile X syndrome identified

The interplay of two proteins that bind to messenger RNA, a molecule that mediates translation of the information encoded in genes into proteins, triggers the appearance of fragile X-associated tremor/ataxia syndrome (FTAX), a late-life disorder associated with the gene that causes fragile X syndrome in children, said researchers from Baylor College of Medicine in Houston and Emory University School of Medicine in a report that appears today in the journal Neuron.

17 Aug 2007

Reactivating a critical gene lost in kidney cancer reduces tumor growth

Researchers at Mayo Clinic Jacksonville, have found that a key gene is often silenced in clear cell renal cell carcinoma, the most common type of kidney cancer, and when they restored that gene in human kidney cancer cells in culture and animal experiments, tumors stopped growing and many disappeared.

17 Aug 2007

Scientists describe a new way of creating novel enzymes

The intricate interplay of proteins and other chemicals that underlies most biological activities requires the participation of enzymes, specialized molecules that accelerate chemical reactions between molecules.

17 Aug 2007

New insight into fragile X tremor/ataxia syndrome

Researchers have reported new insight into the pathology underlying a recently identified neurological disorder that strikes middle-aged adults that is caused by alterations in the same gene that causes fragile X syndrome.

17 Aug 2007