Oncogene News and Research

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An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.

Researchers identify new therapeutic strategies against cancer

New findings open up to new therapeutic strategies against cancer. IGC researchers identify signals emitted by the tumor environment, which controls the migrating capacity of cancer cells.

1 Apr 2020

Scientists pinpoint protein that plays key role in lung cancer and melanoma progression

Scientists from Far Eastern Federal University, University of Geneva (Switzerland), Minjiang University, and Fuzhou University (China) pointed out WDR74 protein playing an important role in lung cancer and melanoma primary tumors/metastases progression.

16 Feb 2020

Researchers discover new mutational phenomenon chromothripsis in cancer

Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis.

6 Feb 2020

Researchers discover how CDK8 oncogene gets activated in healthy humans

Most cancers are caused by a large variety of factors that vary from one person to another. To unravel this complexity, genes that contribute to the development of a respective cancer must be identified. Such genes are called oncogenes. A good example of an oncogene is CDK8: Cyclin-dependent kinase 8.

28 Jan 2020

Protein p38 plays key role in supporting lung cancer growth

In 2018, 1.7 million people died from lung cancer worldwide, a number equivalent to the population of Barcelona. The high mortality rate of lung cancer reflects the need for the development of treatments that are more efficient.

23 Jan 2020

NAU scientists study zebrafish to find powerful melanoma-fighting drugs

Melanoma is the most lethal type of skin cancer and unusually common in Arizona, where residents are exposed to higher-than-average amounts of ultraviolet radiation. However, Northern Arizona University scientists believe the formula for a combination of melanoma-fighting drugs is within reach.

21 Jan 2020

CHOP-led study reveals how genetic variations can influence variety of common diseases

While subtle differences in the number of genes copied from one individual and passed down to the next can be found in many healthy people, their role in disease may be much greater than previously thought.

14 Jan 2020

NAU scientists in search of a powerful combination of melanoma-fighting drugs

Melanoma is the most lethal type of skin cancer and unusually common in Arizona, where residents are exposed to higher-than-average amounts of ultraviolet radiation.

13 Jan 2020

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Cancer immunology drugs, which harness the body's immune system to better attack cancer cells, have significantly changed the face of cancer treatment. People with aggressive cancers are now living longer, healthier lives. Unfortunately, cancer immunology therapy only works in a subset of patients.

9 Dec 2019

Research breakthrough may lead to new therapeutic targets for cancers

Computational modeling is the use of computers to simulate and study the behavior of complex systems. Computational approaches are widely adopted in the bioimedical sciences and can be used to sift through large volumes of complex data to extract recurrent patterns that may point to a disease's causes and effects.

15 Nov 2019

Researchers uncover new and unexploited drug target for childhood cancer

An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at.

12 Nov 2019

Researchers discover new details about several proteins implicated in cancer

Researchers from the Stowers Institute for Medical Research have uncovered new details about several proteins implicated in tumor growth and metastasis, opening a potential avenue for the development of treatments for diseases such as breast cancer.

23 Oct 2019

Peptide-based nanoparticles can suppress pancreatic cancer growth without adverse effects

Despite advances in cancer survival, more than 90 percent of people with pancreatic cancer die within five years. Most patients with pancreatic tumors (and half of those with colorectal cancers) carry a mutation in the KRAS gene, which normally controls cell growth and death.

21 Oct 2019

Epigenetic changes can lead to development of GISTs, other cancers

Most cases of gastrointestinal stromal tumor (GIST), a type of soft-tissue cancer (sarcoma), are caused by mutations in genes that can be effectively targeted with drugs that inhibit the activity of rogue cancer-promoting enzymes.

16 Oct 2019

Researchers propose potential treatment for Ewing sarcomas

Ewing sarcoma is a bone cancer that appears mainly in teenagers. Due to a single defective gene, once it spreads to distant organs it is hard to treat. Researchers at the Weizmann Institute of Science have discovered molecular interactions underlying Ewing sarcomas and proposed a potential treatment, which has shown promise in a study in mice.

2 Oct 2019

Study reveals molecular mechanism of cancer malignancy and development of leukemia

A Waseda University-led research uncovered the molecular mechanism of how a particular cancer-causing oncogene could trigger an onset of acute myeloid leukemia (AML).

30 Sep 2019

Version of an antibiotic drug extends survival in mice with lethal pediatric brain tumors

Versions of an antibiotic drug called DON first isolated from soil bacteria more than 60 years ago have shown promising signs of extending survival in mice models of especially lethal pediatric brain tumors marked by the high expression of a cancer-causing gene known as the MYC oncogene, according to results of two studies from researchers at the Johns Hopkins Kimmel Cancer Center.

23 Sep 2019

Cancer disease incidence and severity influenced by gene mutation, tissue location

The KRAS gene is one of the commonly mutated genes in cancer. More than 40 percent of colorectal cancers have a mutated KRAS gene, or oncogene, that is at least partially responsible for cancer development.

12 Sep 2019

YCC scientists uncover key to help treat many forms of cancer

Yale Cancer Center (YCC) scientists have uncovered the workings of a metabolic pathway or "gauge" that lets cancer cells detect when they have enough nutrients around them to grow.

11 Sep 2019

Researchers develop new cocktail of drugs that shrink pancreatic tumors

Cancer is relentless and resilient. When a drug blocks a cancer cell's main survival pathway, the cell avoids the obstacle by taking different pathways or detours to save itself. This tactic is called "developing resistance," and it's one of the key challenges researchers face when seeking effective therapeutics to combat pancreatic ductal adenocarcinoma (PDA).

9 Sep 2019