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Morphological changes occur rapidly in response to cardiac injury

Cardiac injury leads to significant structural changes in the heart, including enlargement, excess formation of fibrous growth tissue, and abnormalities of the coronary vasculature. While associated factors have been targeted for therapeutic intervention, the results have been conflicting. Most studies have investigated these changes after six days of injury. However, advanced stages of remodeling have already begun by day seven following injury.

4 Sep 2012

Exercise paves way to healthy old age

Middle-aged people who have a high level of physical fitness have a significantly lower and later incidence of chronic conditions in old age than those who are less fit, report researchers.

3 Sep 2012

CT scan appears to predict risk of chronic obstructive pulmonary disease exacerbations

The respective size of two major arteries, visible on a simple computed tomography, or CT, scan, is a strong predictor of the risk of exacerbation of chronic obstructive pulmonary disease, according to new research from the University of Alabama at Birmingham published online Sept. 3, 2012, in the New England Journal of Medicine.

3 Sep 2012

ImThera Medical announces results from targeted hypoglossal neurostimulation study on OSA

ImThera Medical, Inc. today announced that results from the first single-center study of targeted hypoglossal neurostimulation (THN) for obstructive sleep apnea (OSA) will appear in an upcoming print edition of the European Respiratory Journal.

3 Sep 2012

Potential new COPD drug

A study led by researchers at Boston University School of Medicine (BUSM) has shown that a compound used in some skin creams may halt the progression of emphysema and reverse some of the damage caused by the disease. When the compound Gly-His-Lys (GHK) was applied to lung cells from patients with emphysema, normal gene activity in altered cells was restored and damaged aspects of cellular function were repaired.

1 Sep 2012

Targeted intervention improves safety of MRI scans for children with sickle cell disease

Jude Children's Research Hospital reports success using a targeted educational approach to teach young patients to remain motionless during MRI scans, making the process safer.

1 Sep 2012

New intriguing knowledge on blood haemoglobin

Scientists at the research centre MEMBRANES at Aarhus University, Denmark, have completed an old puzzle, which since the 60s from many sides has been regarded as impossible to complete. The challenge was to solve the structure of the protecting protein complex that forms when haemoglobin is released from red cells and becomes toxic. This toxic release of haemoglobin occurs in many diseases affecting red cell stability, e.g. malaria.

1 Sep 2012

Concentration increase of HUWE1 protein leads to intellectual disability

2 to 3 % of the children are born with an intellectual disability. Possibly by a genetic defect, but in 80% of these cases, we do not know - yet - which genes are responsible. VIB researchers at KU Leuven show that increased production of the HUWE1 protein is the cause in some patients.

31 Aug 2012

Sleep apnea’s contribution to diabetic nephropathy needs attention

The effect of obstructive sleep apnea syndrome on the development of diabetic nephropathy requires investigation, say researchers.

31 Aug 2012

DNA synthesis in the 3’ and 5’ direction possible using new template-directed method

When a cell divides, it passes on genetic information by producing copies of its DNA. Chemists have also learned to copy DNA. In the journal Angewandte Chemie, a German team has now introduced a new copying technique that uses a single strand of DNA as the “master copy”, like a cell, but does not require enzymes.

30 Aug 2012

New treatment for severe dry eye is now available at U-M’s Kellogg

A new treatment available at the University of Michigan Kellogg Eye Center—prosthetic replacement of the ocular surface ecosystem or PROSE—provides relief to patients who suffer from severe dry eye, often the result of cancer or complex corneal disease.

29 Aug 2012

Cyclin D3 protein regulates size and quantity of RBCs

The adult human circulatory system contains between 20 and 30 trillion red blood cells (RBCs), the precise size and number of which can vary from person to person. Some people may have fewer, but larger RBCs, while others may have a larger number of smaller RBCs. Although these differences in size and number may seem inconsequential, they raise an important question: Just what controls these characteristics of RBCs?

29 Aug 2012

GeneTex to introduce new antibody against hypoxia-inducible factor 1alpha

GeneTex, Inc., a leading manufacturer of antibodies, has announced that they will be launching a new antibody against HIF1a (hypoxia-inducible factor 1alpha).

29 Aug 2012

Leg compressions after stroke appear to trigger natural protective mechanisms that reduce damage

Successive, vigorous bouts of leg compressions following a stroke appear to trigger natural protective mechanisms that reduce damage, researchers report.

28 Aug 2012

New method helps engineer tissues with embedded nanoscale networks

A multi-institutional research team has developed a method for embedding networks of biocompatible nanoscale wires within engineered tissues. These networks—which mark the first time that electronics and tissue have been truly merged in 3D—allow direct tissue sensing and potentially stimulation, a potential boon for development of engineered tissues that incorporate capabilities for monitoring and stimulation, and of devices for screening new drugs.

27 Aug 2012

Spironolactone should be considered as a treatment option in hypertensive patients with DHF

Mineralocorticoid receptor antagonists should be considered as a treatment option in hypertensive patients with diastolic heart failure, said Professor Burkert Pieske presenting results today of the Aldosterone Receptor Blockade in Diastolic Heart Failure (Aldo-DHF) study at ESC Congress 2012.

27 Aug 2012

IABP does not improve blood pressure symptoms in patients with cardiogenic shock

A balloon pump inserted in the aorta is currently the most widely used support device in the treatment of cardiogenic shock and, since its introduction in 1968, has been used in several million people.

27 Aug 2012

XJB-5-131 prevents secondary damage of severe traumatic brain injury

Treatment with an agent that blocks the oxidation of an important component of the mitochondrial membrane prevented the secondary damage of severe traumatic brain injury and preserved function that would otherwise have been impaired, according to a research team from the University of Pittsburgh School of Medicine, Graduate School of Public Health and Department of Chemistry in a report published online today in Nature Neuroscience.

27 Aug 2012

Study investigates effects of passive smoking on the levels of three parameters

"It is well known that passive smoking is harmful for cardiovascular health, but the mechanism has not yet been discovered," said Dr Kaya. "We investigated the effects of passive smoking on the levels of three parameters - mean platelet volume (MPV), carboxyhemoglobin (COHb) and lactate - in an effort to further understand this mechanism. We also looked at the correlation between the three parameters."

27 Aug 2012

Creighton University research to improve patient care and outcomes in CAD treatment

Since 1990, Creighton University School of Medicine professor and researcher Devendra K. Agrawal, Ph.D., has been awarded more than $20 million in research grants to study coronary artery heart disease. He is determined to eradicate the impact of this heart disease—the number one killer of men and women in the United States.

26 Aug 2012

Oxygen News and Research

Morphological changes occur rapidly in response to cardiac injury

Exercise paves way to healthy old age

CT scan appears to predict risk of chronic obstructive pulmonary disease exacerbations

ImThera Medical announces results from targeted hypoglossal neurostimulation study on OSA

Potential new COPD drug

Targeted intervention improves safety of MRI scans for children with sickle cell disease

New intriguing knowledge on blood haemoglobin

Concentration increase of HUWE1 protein leads to intellectual disability

Sleep apnea’s contribution to diabetic nephropathy needs attention

DNA synthesis in the 3’ and 5’ direction possible using new template-directed method

New treatment for severe dry eye is now available at U-M’s Kellogg

Cyclin D3 protein regulates size and quantity of RBCs

GeneTex to introduce new antibody against hypoxia-inducible factor 1alpha

Leg compressions after stroke appear to trigger natural protective mechanisms that reduce damage

New method helps engineer tissues with embedded nanoscale networks

Spironolactone should be considered as a treatment option in hypertensive patients with DHF

IABP does not improve blood pressure symptoms in patients with cardiogenic shock

XJB-5-131 prevents secondary damage of severe traumatic brain injury

Study investigates effects of passive smoking on the levels of three parameters

Creighton University research to improve patient care and outcomes in CAD treatment

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