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Center for LAM Research and Clinical Care at BWH to conduct phase I combination drug trial

The Center for LAM Research and Clinical Care at Brigham and Women's Hospital (BWH) has been awarded a $1 million plus, four-year grant from the U.S. Department of Defense Office of the Congressionally Directed Medical Research Programs to fund their work on lymphangioleiomyomatosis.

8 Feb 2012

First sign of coronary heart disease in men could be death

The healthy heart movement in recent years has focused largely on heart disease as the No. 1 killer of women. But the same statistic is true for men, and the reality is grim: The first sign that a man has coronary heart disease could be death, says one University of Alabama at Birmingham expert.

8 Feb 2012

ED can lead to potential cardiovascular disease in men

More than 12 million men have type 2 diabetes and that number is growing at an alarming rate. A little talked about complication of this disease is erectile dysfunction (ED), which can lead to an even more serious condition.

7 Feb 2012

Merck Serono enters development agreement with Threshold for hypoxia-targeted drug

Merck Serono, a division of Merck KGaA, Darmstadt, Germany, today announced that a global agreement was signed with Threshold Pharmaceuticals, Inc., South San Francisco, to co-develop and commercialize TH-302, Threshold's small molecule hypoxia-targeted drug.

3 Feb 2012

Exercise under hypoxic conditions provides improvements in glycemic control

Intermittent exercise with and without low oxygen concentrations (or hypoxia) can improve insulin sensitivity in type 2 diabetics, however exercise while under hypoxic conditions provides greater improvements in glycemic control than intermittent exercise alone, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

3 Feb 2012

Anemia triples risk of dying within a year after having a stroke

Being anemic could more than triple your risk of dying within a year after having a stroke, according to research presented at the American Stroke Association's International Stroke Conference 2012.

3 Feb 2012

Multiple DNA repair defect in monocytes

Scientists working with Professor Bernd Kaina of the Institute of Toxicology at the Medical Center of Johannes Gutenberg University Mainz have demonstrated for the first time that certain cells circulating in human blood - so-called monocytes - are extremely sensitive to reactive oxygen species (ROS).

3 Feb 2012

Colchicine, another weapon against cancer

Finding a drug that targets only the diseased cells in our body and is otherwise harmless to healthy tissue is a goal for cancer researchers. It's driven the work of Professor Laurence Patterson, Director of the Institute of Cancer Therapeutics at the University of Bradford, and his team of researchers.

2 Feb 2012

Researchers identify mechanism that leads to ischemia-reperfusion damage

For patients with incurable pulmonary conditions, a lung transplantation is the only available treatment option. However, suitable donor organs are scarce, and even getting them to prospective recipients is not easy. As Professor Alexander Dietrich of the Walther Straub Institute of Pharmacology and Toxicology at LMU explains, "An isolated lung which is no longer perfused with blood can become so severely damaged that it is no longer functional. This so-called ischemia-reperfusion injury is one of the major problems in the field of lung transplantation."

2 Feb 2012

Study shows stalled growth in extended-wear lens prescribing

After more than a decade on the market, extended-wear (EW) contact lenses still haven't caught on among patients and eye care professionals, reports the February issue of Optometry and Vision Science, official journal of the American Academy of Optometry.

2 Feb 2012

Frontal NIRS can help physicians monitor hospitalized stroke patients

A research team led by investigators at Mayo Clinic in Florida has found that a small device worn on a patient's brow can be useful in monitoring stroke patients in the hospital. The device measures blood oxygen, similar to a pulse oximeter, which is clipped onto a finger.

2 Feb 2012

Healthy lung tissue transplantation shows promise for patients with pulmonary diseases

For patients suffering from severe pulmonary diseases including emphysema, lung cancer or fibrosis, transplantation of healthy lung tissue may offer the best chance for survival. The surgical procedure, however, faces two primary challenges: an acute shortage of donor lungs and rejection of transplanted tissue by the recipient's immune system.

2 Feb 2012

OPN-305 may improve survival outcomes for kidney transplant patients

New research published online in the FASEB Journal details a new antibody, called "OPN-305" that may significantly improve survival outcomes for those receiving donated kidneys and other organs.

1 Feb 2012

BiOWiSH helps communities improve wastewater treatment operations

A novel technology named BiOWiSH is helping communities in emerging markets improve their wastewater treatment operations without building or expanding infrastructure, according to the findings of a new case study.

1 Feb 2012

Potential way to block second wave of death from pneumonia treatment

An international research team may have found a way to block a second wave of death that can result from pneumonia treatment.

1 Feb 2012

Crizotinib can treat ROS1-driven tumors

A report from investigators at the Massachusetts General Hospital (MGH) Cancer Center has defined the role of a recently identified gene abnormality in a deadly form of lung cancer. Tumors driven by rearrangements in the ROS1 gene represent 1 to 2 percent of non-small-cell lung cancers (NSCLC), the leading cause of cancer death in the U.S.

1 Feb 2012

Research advances understanding of hypoxic response

A new family of proteins which regulate the human body's 'hypoxic response' to low levels of oxygen has been discovered by scientists at Barts Cancer Institute at Queen Mary, University of London and The University of Nottingham.

30 Jan 2012

OHSU research sheds light on molecules involved in cardiorespiratory control

Researchers at Oregon Health & Science University have discovered that a molecule critical to the development and plasticity of nerve cells - brain-derived neurotrophic factor -- is severely lacking in brainstem neurons in mutations leading to Rett syndrome, a neurological developmental disorder.

30 Jan 2012

Study shows grape seed extract kills head and neck squamous cell carcinoma cells

Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million.

27 Jan 2012

Link between genetic abnormalities and cerebral palsy

For years it was thought that a difficult birth and other perinatal factors were the leading causes of cerebral palsy (CP), a group of disorders that can involve brain and nervous system functions such as movement, learning, hearing, seeing and thinking. Now, researchers at Geisinger Health System find that the majority of cerebral palsy causes may in fact be caused by genetic abnormalities.

27 Jan 2012