Pathogen News and Research

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New molecules with many branches will help unleash potential of nanotechnology

Materials science and the pharmaceutical industry could soon be revolutionized by emerging nanotechnologies based on designer molecules with long complex tree-and branch structures. Such molecules offer almost limitless scope for design of bespoke compounds for specific applications in disease therapy, for novel materials such as resins, as well as electronic displays, and energy storage. Almost every field involving design and synthesis of chemical compounds will be transformed by the arrival of technologies allowing nanoscale design of these branched molecules, known as hyperbranched polymers.

26 Oct 2008

Researchers downplay value of mandatory universal nasal screening of patients for MRSA

Three Virginia Commonwealth University epidemiologists are downplaying the value of mandatory universal nasal screening of patients for MRSA, arguing that proven, hospital-wide infection control practices can prevent more of the potentially fatal infections.

23 Oct 2008

Discovery of earliest known cases of human tuberculosis in Neolithic village

The discovery of the earliest known cases of human tuberculosis (TB) in bones found submerged off the coast of Israel shows that the disease is 3000 years older than previously thought. Direct examination of this ancient DNA confirms the latest theory that bovine TB evolved later than human TB.

14 Oct 2008

DNA of good bacteria drives intestinal response to infection

A new study shows that the DNA of so-called "good bacteria" that normally live in the intestines may help defend the body against infection.

2 Oct 2008

Tuberculosis bacterium uses its sugar coat to sweeten its chances of living in lungs

Common strains of tuberculosis-causing bacteria have hijacked the human body's immune response to play tricks on cells in the lungs, scientists say.

29 Sep 2008

Catching the blood cell bus gives fatal yeast infection a clean getaway

Yeast fungus cells that kill thousands of AIDS patients every year escape detection by our bodies' defences by hiding inside our own defence cells, and hitch a ride through our systems before attacking and spreading, scientists heard today (Tuesday 9 September 2008) at the Society for General Microbiology's 163rd meeting being held this week at Trinity College, Dublin.

8 Sep 2008

Scientists uncover molecule that keeps pathogens like salmonella in check

Scientists at UT Southwestern Medical Center have found a potential new way to stop the bacteria that cause gastroenteritis, tularemia and severe diarrhea from making people sick.

21 Aug 2008

Researchers uncover attack mechanism of illness-inducing bacterium found in shellfish

An infectious ocean-dwelling bacterium found in oysters and other shellfish kills its host's cells by causing them to burst, providing the invader with a nutrient-rich meal, researchers at UT Southwestern Medical Center have found.

18 Aug 2008

Testosterone and disease transmission

High levels of testosterone may be a key factor in spreading disease among mice, according to biologists. The findings could help explain why males in a population are often more likely to get infected, and transmit disease.

10 Aug 2008

BioNanomatrix awarded NIH grant for nanoscale platform for single-molecule DNA mapping

BioNanomatrix, Inc. has announced receipt of a grant from the National Human Genome Research Institute of the U.S. National Institutes of Health (NIH). Under the direction of BioNanomatrix principal investigator Dr. Ming Xiao, the two-year $399,020 project will develop a nanoscale platform for single-molecule haplotyping imaging and analysis of long strands of DNA at ultra-high resolution in a massively parallel format.

6 Aug 2008

An unsuspected weakness in tuberculosis - potential drug target

With antibiotic resistance on the rise, tuberculosis is emerging as a bigger global health threat than ever before.

31 Jul 2008

Genome sequencing study reveals new genetic typhoid fever signatures

For the first time, next-generation DNA sequencing technologies have been turned on typhoid fever - a disease that kills 600,000 people each year. The results will help to improve diagnosis, tracking of disease spread and could help to design new strategies for vaccination.

27 Jul 2008

Scientists find structure of critical Ebola virus protein

Scientists at the Scripps Research Institute have uncovered the structure of a critical protein from the Ebola Virus that allows viral entry in human cells.

23 Jul 2008

Could arthritis wonder drugs provide clues for all disease?

Drugs that have helped treat millions of rheumatoid arthritis sufferers may hold the key to many more medical conditions, including atherosclerosis - a leading cause of heart disease - says the researcher who jointly invented and developed them.

From The University of Manchester 17 Jul 2008

FDA approves Energex Systems non-drug therapy for HIV research

Energex Systems, Inc. announced today that it has been granted approval from the Federal Food and Drug Administration (FDA) to utilize its experimental HemoModulation therapy in a clinical trial of HIV infected patients. The purpose of the study will be to demonstrate safety and monitor viral load changes in patients who are not yet eligible for antiviral drug therapy.

14 Jul 2008

Breakthrough findings point to targets for Ebola virus drugs and vaccines

Described in the July 10, 2008 issue of the journal Nature, the research reveals the shape of the Ebola virus spike protein, which is necessary for viral entry into human cells, bound to an immune system antibody acting to neutralize the virus. The structure provides a major step forward in understanding how the deadly virus works, and may be useful in the development of potential Ebola virus vaccines, or treatments for those infected.

10 Jul 2008

New understanding of how malaria parasite survives in and totally changes red blood cells

A new study-done on a scale an order of magnitude greater than anything previously attempted in the field of malaria-has uncovered an arsenal of proteins produced by the malaria parasite that allows it to hijack and remodel human red blood cells, leaving the oxygen-carrying cells stiff and sticky.

8 Jul 2008

Potential new way to vaccinate against avian flu

Researchers at the University of Pennsylvania School of Medicine have identified a potential new way to vaccinate against avian flu. By delivering vaccine via DNA constructed to build antigens against flu, along with a minute electric pulse, researchers have immunized experimental animals against various strains of the virus.

1 Jul 2008

Increasing number of severe bone infections, health complications in children linked to MRSA

The emergence of methicillin-resistant Staphylococcus aureus (MRSA) as a major pathogen has led to more complications and longer hospital stays for children with acute bone infections, UT Southwestern Medical Center researchers report

30 Jun 2008

Viruses hitch a ride in the cell

Viruses can travel around cells they infect by hitching a ride on a microscopic transport system, according to new research. Cells are exposed to foreign DNA and RNA and it is understood that some of this genetic material can be integrated into the host genome. Using modern microscopic techniques, scientists have been able to see how virus DNA is transported in the cell.

23 Jun 2008