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DNA vaccines may offer hope in multiple sclerosis

Authors from the VA North Texas Health Care System Neurology Section and the Department of Neurology at the University of Texas Southwestern Medical Center at Dallas have highlighted the potential benefits for DNA-based vaccine administration in patients with multiple sclerosis (MS).

24 Apr 2008

On the trail of rogue genetically modified pathogens

Bacteria can be used to engineer genetic modifications, thereby providing scientists with a tool to combat many challenges in areas from food production to drug discovery.

18 Mar 2008

Soil-dwelling bacteria provide potential new antibiotics

MIT biologists have provoked soil-dwelling bacteria into producing a new type of antibiotic by pitting them against another strain of bacteria in a battle for survival.

27 Feb 2008

Researchers seek trial participants for experimental HIV vaccine called PENNVAX-B

University of Pennsylvania School of Medicine researchers are recruiting healthy, HIV-negative adults to participate in a phase I clinical trial of an experimental HIV vaccine called PENNVAX-B, a DNA-based vaccine which is made using synthetic DNA-based HIV genes.

4 Feb 2008

Research could turn the tables on superbugs

Scientists in Australia and America believe they have found a way to deal with the increasing antibiotic resistance of deadly superbugs such as MRSA.

27 Dec 2007

Australian researchers tackle antibiotic resistance

The development of antibiotic resistant strains of bacteria that are problematic and expensive to treat is a major healthcare problem around the world. The "selective pressure" of antibiotic usage inevitably results in the emergence and proliferation of resistant bacteria.

20 Dec 2007

There is a new twist on the question of how biological clocks work

In recent years, scientists have discovered that biological clocks help organize a dizzying array of biochemical processes in the body. Despite a number of hypotheses, exactly how the microscopic pacemakers in every cell in the body exert such a widespread influence has remained a mystery.

21 Nov 2007

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

Gene therapy administered intravenously could be an effective agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb, according to an animal study presented today by University of Pittsburgh researchers at the 49th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Los Angeles.

28 Oct 2007

Researchers discover important tool in understanding differentiation in human embryonic stem cells

Researchers at the University of Minnesota's Stem Cell Institute have described how an existing genetic tool can be used to study how human embryonic stem cells differentiate.

24 Oct 2007

Transposons could make for safer gene delivery system

To move a gene from point A to point B, scientists and gene therapists have two proven options: a virus, which can effectively ferry genes of interest into cells, and a plasmid, an engineered loop of DNA that can do the same thing, albeit usually only on a short-term basis.

27 Sep 2007

Drug resistance gene has spread from East Coast to Midwest

A resistance gene that allows bacteria to beat an important class of antibiotics has started to appear in microorganisms taken from Midwestern patients, according to researchers at Washington University School of Medicine in St. Louis.

20 Sep 2007

Potential vaccine target for chlamydia

Scientists at Children's Hospital of Pittsburgh of UPMC have identified a potential target for the development of a vaccine against Chlamydia trachomatis, the most prevalent sexually transmitted bacterial infection in the world.

13 Sep 2007

Directed nanoparticles deliver gene therapy

After binding DNA segments to tiny iron-containing spheres called nanoparticles, researchers have used magnetic fields to direct the nanoparticles into arterial muscle cells, where the DNA could have a therapeutic effect.

31 Jul 2007

Mushrooms show promise for creation of new drugs

Mushrooms might serve as biofactories for the production of various beneficial human drugs, according to plant pathologists who have inserted new genes into mushrooms.

23 Jun 2007

Nanoparticle-enabled peptide delivery triggers tumor regression

Cells possess a variety of ways of dealing with mutations that can cause them to grow uncontrollably and eventually form a tumor. The tumor suppressor gene p53 plays a critical role in these cancer prevention processes, largely by triggering a form a cell death known as apoptosis.

14 Jun 2007

Sangamo BioSciences starts phase 2 trial of therapy diabetic neuropathy

Sangamo BioSciences has announced that the company has initiated a repeat-dosing, multi-center Phase 2 clinical trial of SB-509 in subjects with moderate to severe diabetic peripheral sensory motor neuropathy (DN).

27 Apr 2007

Nanoparticle delivery system delivers cancer-suppressing gene in M. D. Anderson trial

A cancer-suppressing gene has been successfully delivered into the tumors of stage 4 lung cancer patients via an intravenously administered lipid nanoparticle in a phase I clinical trial at The University of Texas M. D. Anderson Cancer Center.

18 Apr 2007

Expression Genetics completes phase I trial of lead drug candidate, EGEN-001

Expression Genetics, Inc., has announced the completion of a Phase I clinical study evaluating the Company's lead drug candidate, EGEN-001.

17 Apr 2007

Gelatin-based nanoparticles deliver therapeutic genes to human breast cancer

Northeastern University professor Mansoor Amiji and graduate student Sushma Kommareddy have published a new paper that examines the potential of engineered gelatin-based nanoparticles to deliver therapeutic genes to human breast cancer tumors implanted in mice.

14 Apr 2007

New patented technology for next generation of DNA and RNA microarrays

A novel invention developed by a scientist from New York Institute of Technology (NYIT) could revolutionize biological and clinical research and may lead to treatments for cancer, AIDS, Alzheimer's, diabetes, and genetic and infectious diseases.

13 Feb 2007