Plasmodium falciparum News and Research

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Novartis delivers 100 million child-friendly antimalarial treatments to 39 countries

One hundred million treatments of Coartem- Dispersible (artemether-lumefantrine), an antimalarial developed especially for children with Plasmodium falciparum malaria, have been delivered by Novartis to 39 malaria-endemic countries, Medicines for Malaria Venture (MMV) announced today.

23 Feb 2012

EMA grants positive scientific opinion for Pyramax to treat malaria

Pyramax-, a fixed-dose combination of pyronaridine and artesunate, becomes the first antimalarial to be granted a positive scientific opinion from the European Medicines Agency (EMA) under Article 58. This once daily, 3-day treatment is indicated for acute, uncomplicated Plasmodium falciparum and blood-stage Plasmodium vivax malaria in adults and children over 20 kg.

22 Feb 2012

Researchers share libraries of chemical compounds to spur development of drug candidates

Nature reports how "in the hunt for drugs that target diseases in the developing world, ... pharmaceutical companies are making entire libraries of chemical compounds publicly available, allowing researchers to rifle through them for promising drug candidates."

16 Feb 2012

Study shows how malaria parasite changes into banana form before sexual reproduction

New research from the University of Melbourne shows how the malaria parasite (Plasmodium falciparum) changes into a banana shape before sexual reproduction, a finding that could provide targets for vaccine or drug development and may explain how the parasite evades the human immune system.

14 Feb 2012

New technique to overcome genetic oddity of P. falciparum

The parasite that causes malaria is a genetic outlier, which has prevented scientists from discovering the functions of most of its genes. Researchers at National Jewish Health and Yale University School of Medicine have devised a technique to overcome the genetic oddity of Plasmodium falciparum, the major cause of human malaria.

27 Jan 2012

New maps, online portal reveal current global pattern of malaria

A new suite of malaria maps has revealed in unprecedented detail the current global pattern of the disease, allowing researchers to see how malaria has changed over a number of years.

24 Jan 2012

PfSET10 molecule plays a crucial role in malaria infection

The discovery by researchers from the Walter and Eliza Hall Institute of a molecule that is key to malaria's 'invisibility cloak' will help to better understand how the parasite causes disease and escapes from the defenses mounted by the immune system.

19 Jan 2012

Malaria vaccine shows early success

An experimental vaccine for malaria has been developed by British scientists. It has shown early potential to neutralize many, perhaps all, strains of the deadliest malaria parasite.

21 Dec 2011

University of Oxford scientists develop new candidate malaria vaccine

A new candidate malaria vaccine with the potential to neutralise all strains of the most deadly species of malaria parasite has been developed by a team led by scientists at the University of Oxford.

21 Dec 2011

BCX4945 proves effective at clearing malaria infections

An antimalarial agent developed by researchers at Albert Einstein College of Medicine of Yeshiva University proved effective at clearing infections caused by the malaria parasite most lethal to humans - by literally starving the parasites to death. The novel research, carried out on a small number of non-human primates, could bolster efforts to develop more potent therapies against one of the world's leading killers.

8 Dec 2011

New global map shows difficult-to-treat malaria strain remains prevalent in Asia, Latin America

"Declining malaria deaths in Africa and progress toward an effective malaria vaccine are raising hopes the disease will soon be eradicated worldwide," but "researchers at the annual meeting of the American Society of Tropical Medicine and Hygiene (ASTMH) in Philadelphia, Pennsylvania, [on Monday] unveiled a new global malaria map that raises new concerns about the disease," VOA News writes.

7 Dec 2011

Mutation on surface of human red blood cells provides protection against vivax malaria

A mutation on the surface of human red blood cells provides protection against malaria caused by the parasite Plasmodium vivax, research led by Case Western Reserve University School of Medicine shows.

2 Dec 2011

Malaria is almost under control in Suriname

Malaria is almost under control in Suriname. According to an impact study conducted by Hélène Hiwat - van Laar, who was awarded a PhD on the subject on 21 November at Wageningen University, a five-year control programme with new strategies has proved successful. The people most at risk nowadays are the mobile gold miner communities, especially those along the French Guianese border.

24 Nov 2011

Scientists solve mystery behind why people with defective hemoglobin do not contract malaria

Why do people with a hereditary mutation of the red blood pigment hemoglobin not contract severe malaria? Scientists in the group headed by Prof. Michael Lanzer of the Department of Infectious Diseases at Heidelberg University Hospital have now solved this mystery.

19 Nov 2011

Study detects contrasting patterns of malaria drug resistance in humans, mosquitoes

A study conducted by researchers at the Johns Hopkins Malaria Research Institute and their Zambian colleagues detected contrasting patterns of drug resistance in malaria-causing parasites taken from both humans and mosquitoes in rural Zambia.

16 Nov 2011

New protein microarray technology could eradicate malaria

A new research technology is revealing how humans develop immunity to malaria, and could assist programs aimed at eradicating this parasitic disease.

2 Nov 2011

First results from phase 3 malaria vaccine candidate trial

First results from a large-scale Phase III trial of RTS,S, published online today in the New England Journal of Medicine (NEJM), show the malaria vaccine candidate to provide young African children with significant protection against clinical and severe malaria with an acceptable safety and tolerability profile. The results were announced today at the Malaria Forum hosted by the Bill & Melinda Gates Foundation in Seattle, Washington.

18 Oct 2011

New malaria study in Africa offers evidence of method to bypass, or delay, insecticide resistance

Indoor spraying with the insecticide bendiocarb has dramatically decreased malaria transmission in many parts of Benin, new evidence that insecticides remain a potent weapon for fighting malaria in Africa despite the rapid rise of resistance to an entire class of mosquito-killing compounds, according to a study published today in the October edition of The American Journal of Tropical Medicine and Hygiene.

5 Oct 2011

Researchers validate two parasite enzymes as potential anti-malarial drug targets

Researchers at the Perelman School of Medicine at the University of Pennsylvania, Monash University, and Virginia Tech have used a set of novel inhibitors to analyze how the malaria parasite, Plasmodium falciparum, uses enzymes to chew up human hemoglobin from host red blood cells as a food source.

28 Sep 2011

Link between changes in malaria parasite and absorption of pharmaceutical compounds

Professor Max Petzold at the Nordic School of Public Health shows in a recent article a link between changes in the malaria parasite and the absorption of pharmaceutical compounds. Increased knowledge of the malaria parasite and the connection with the development of resistance may contribute to the development of new malaria treatments.

26 Sep 2011