Plasmodium falciparum News and Research

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New way to prevent malaria bugs from breeding

A new international collaboration reports that the compound called TCMDC-135051 is capable of preventing the synthesis of a protein that is required for growth in Plasmodium falciparum, one of the species of the Plasmodium parasite that causes malaria. The study, reported in the journal Science, could lead to the development of a new antimalarial drug.

8 Oct 2019

New model system uses red blood cells to study malaria invasion

Researchers at the University of Bristol and Imperial College London have established a new model system that uses red blood cells grown in the laboratory to study how malaria parasites invade red blood cells.

29 Aug 2019

Study sheds light on emergence and spread of drug-resistant malaria parasites in Africa

In the first continent-wide genomic study of malaria parasites in Africa, scientists have uncovered the genetic features of Plasmodium falciparum parasites that inhabit different regions of the continent, including the genetic factors that confer resistance to anti-malarial drugs.

23 Aug 2019

Mosquito surveillance in Madagascar reveals new insight into malaria transmission

The Ministry of Public Health in Madagascar has reported thousands of malaria cases over the past months. In March, more than 600 cases of malaria were reported weekly and at least 2,000 cases have been reported in less than a month. As a result, efforts to curb the outbreak were initiated.

12 Jul 2019

Proteasome inhibitors show potential for combating multidrug-resistant malaria

Proteasome inhibitors have significant promise as components of novel combination therapies to treat multidrug-resistant malaria, according to a study published June 6 in the open-access journal PLOS Pathogens by David Fidock, Caroline Ng, and Barbara Stokes of Columbia University Irving Medical Center, Matthew Bogyo of Stanford University School of Medicine, and colleagues.

From PLOS ONE 10 Jun 2019

Comprehensive molecular test introduced for diagnosis of malaria caused by P. vivax parasites

Human Diagnostics Worldwide, EIKEN CHEMICAL CO., LTD. and the Foundation for Innovative New Diagnostics announced today the launch of the first commercially available molecular diagnostic test for the detection of malaria caused by Plasmodium vivax parasites.

23 Apr 2019

Mass drug administration can offer community-level protection against malaria

Researchers have provided the first evidence that mass drug administration can grant community-level protection against Plasmodium falciparum (P. falciparum) malaria.

16 Apr 2019

Researchers call for review of drug-based strategies to prevent malaria in pregnant women

A global team of researchers, led by a research team at the Liverpool School of Tropical Medicine (LSTM), are calling for a review of drug-based strategies used to prevent malaria infections in pregnant women, in areas where there is widespread resistance to existing antimalarial medicines.

26 Mar 2019

Study: Window screens can suppress mosquito populations, reduce malaria in Tanzania

In an article published today in Lancet Planetary Health, a team from the Ifakara Health Institute (IHI) and Liverpool School of Tropical Medicine (LSTM), provides evidence that even window screens with no insecticide suppressed mosquito populations and dramatically reduced malaria prevalence in the Tanzanian city of Dar es Salaam.

22 Mar 2019

Scientists develop novel way with genome sequences to study widespread form of malaria

Scientists at the Institute of Genome Sciences at the University of Maryland School of Medicine have developed a novel way with genome sequences to study and better understand transmission, treat and ultimately eradicate Plasmodium vivax, the most widespread form of malaria. P. vivax is a single-celled transmitted by mosquitoes.

11 Feb 2019

Parasites from children with cerebral malaria stick preferentially in their brains, shows research

A team at LSTM with their collaborators in Malawi and Denmark have provided, for the first time, evidence which links the ability of red blood cells infected with the malaria parasite to bind to the cells lining the blood vessels of the brain, with the clinical syndrome cerebral malaria.

11 Jan 2019

ERADA launches first diagnostic saliva test for malaria

ERADA Technology Alliance Ltd, pioneers of innovative, rapid diagnostic solutions for early detection of infectious diseases, have announced the imminent launch of a world first diagnostic saliva test for malaria.

2 Jan 2019

Novel ferrocenyl phosphines developed as potent antimalarial drugs

A team of researchers from the Singapore University of Technology and Design and Nanyang Technological University have developed novel ferrocene-based molecules that impair the malaria parasite's metabolic function leading to parasite death.

20 Dec 2018

Study reveals mechanism by which malaria parasite converts from its asexual to sexual form

A study led by the Barcelona Institute for Global Health (ISGlobal) - an institution supported by "la Caixa" Foundation- reveals a new mechanism by which the malaria parasite Plasmodium falciparum converts from its asexual to its sexual form, which can be transmitted to the mosquito.

27 Nov 2018

UC Scientist receives NIH grant for developing new malaria therapeutic strategies

A scientist at the University of California, Riverside, who researches the malaria-causing parasite, Plasmodium falciparum, is the principal investigator, or PI, on two grants from the National Institutes of Health, or NIH, totaling nearly $6.6 million. Funding from each grant is for five years.

1 Nov 2018

New mathematical model helps understand transmission of drug-resistant malarial parasites

A new mathematical model for malaria shows how competition between parasite strains within a human host reduces the odds of drug resistance developing in a high-transmission setting.

29 Aug 2018

Researchers decipher role of key protein that malaria parasite uses to obtain nutrients

Researchers from the National Institutes of Health and other institutions have deciphered the role of a key protein that the malaria parasite Plasmodium falciparum uses to obtain nutrients while infecting red blood cells.

27 Aug 2018

Drug-resistant malaria strains tend to evolve in lower risk regions

New drug-resistant strains of the parasite that causes malaria tend to evolve in regions with a lower risk of malaria. This is because in hard-hit areas with high transmission rates, like sub-Saharan Africa, they get outcompeted by the more common, drug-sensitive strains inside the human host.

24 Aug 2018

Genome sequences of ape parasites provide insights on origin and early evolution of malaria

The genome sequences of ape parasites related to Plasmodium vivax (P. vivax), the main source of mosquito-borne malaria outside Africa, provide insights on the origin and early evolution of the human parasite.

21 Aug 2018

Genetically modified mosquitoes and special bed nets help tackle deadly diseases

Researchers at the Imperial College’s South Kensington campus have successfully created genetically modified mosquitoes that would stop them from multiplying and spreading dreaded diseases such as malaria, Dengue, Chikungunya and Zika that kill millions worldwide annually.

13 Aug 2018