Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

University of Leeds researchers make new synthetic anti-cancer molecule

Researchers at the University of Leeds have made a new synthetic anti-cancer molecule that targets two key mechanisms in the spread of malignant tumours through the body.

13 Nov 2014

U of G research may lead to novel treatment approaches for late-stage ovarian cancer

In a potential breakthrough against ovarian cancer, University of Guelph researchers have discovered how to both shrink tumours and improve drug delivery, allowing for lower doses of chemotherapy and reducing side effects.

13 Nov 2014

Study defines, establishes criteria for primary age-related tauopathy

A multi-institutional study has defined and established criteria for a new neurological disease closely resembling Alzheimer's disease called primary age-related tauopathy (PART). Patients with PART develop cognitive impairment that can be indistinguishable from Alzheimer's disease, but they lack amyloid plaques. Awareness of this neurological disease will help doctors diagnose and develop more effective treatments for patients with different types of memory impairment.

13 Nov 2014

Bevacizumab–erlotinib combined efficacy may depend on VEGF level

Bevacizumab may enhance the antitumour activity of erlotinib by increasing the intratumoural concentration of erlotinib in some non-small-cell lung cancers expressing high levels of vascular endothelial growth factor, Japanese researchers report.

13 Nov 2014

New NIH-funded study aims to find novel way to treat iron deficiency anemia in children

Penn State College of Medicine and University of Wisconsin have been awarded a five-year, $2.5 million grant from the National Institutes of Health to fund the study of a novel way to treat iron deficiency anemia in children. Iron deficiency is the most common nutritional deficiency and the leading cause of anemia in the United States.

13 Nov 2014

Study identifies genetic alterations that contribute to growth and recurrence of Ewing sarcoma

An international collaboration has identified frequent mutations in two genes that often occur together in Ewing sarcoma (EWS) and that define a subtype of the cancer associated with reduced survival.

13 Nov 2014

Novel method could improve treatment for infants, young children suffering from HIV/AIDS

A novel method of altering a protein in milk to bind with an antiretroviral drug promises to greatly improve treatment for infants and young children suffering from HIV/AIDS, according to a researcher in Penn State's College of Agricultural Sciences.

12 Nov 2014

Effecting changes to FosB gene could help control addiction, depression

Regulation of a single, specific gene in a brain region related to drug addiction and depression is sufficient to reduce drug and stress responses, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published October 27 online in the journal Nature Neuroscience.

12 Nov 2014

Scientists identify new therapeutic targets, screening test to uncover compounds for memory disorders

In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have identified a number of new therapeutic targets for memory disorders and have developed a new screening test to uncover compounds that may one day work against those disorders.

12 Nov 2014

RPCI researchers identify two novel candidate prognostic markers for ovarian cancer

Cancer researchers at Roswell Park Cancer Institute have identified two independent classes of novel candidate prognostic markers for ovarian cancer, advancing efforts to develop targeted therapies for the disease. The findings resulted from two separate studies published in the peer-reviewed journal PLoS ONE and based on data from The Cancer Genome Atlas (TCGA), the world's largest public database on gene expression in different tumor types.

12 Nov 2014

Researchers identify key protein that can reduce severity of disease equivalent to MS in mice

In multiple sclerosis, the immune system goes rogue, improperly attacking the body's own central nervous system. Mobility problems and cognitive impairments may arise as the nerve cells become damaged.

12 Nov 2014

Research finding could lead to new therapies for preventing growth of plexiform neurofibromas

UT Southwestern Medical Center researchers have determined the specific type of cell that gives rise to large, disfiguring tumors called plexiform neurofibromas, a finding that could lead to new therapies for preventing growth of these tumors.

11 Nov 2014

New findings could help develop therapeutic options for glycogen storage disease

Glycogen storage disorders, which affect the body's ability to process sugar and store energy, are rare metabolic conditions that frequently manifest in the first years of life. Often accompanied by liver and muscle disease, this inability to process and store glucose can have many different causes, and can be difficult to diagnose.

11 Nov 2014

Stopping the death of synapses: an interview with Dr Soledad Galli

Synapses are the sites that connect neurons – sites where information is passed from one neuron to another. They are highly specialized structures and synaptic function is crucial for normal brain function.

11 Nov 2014

Five simple steps to reduce type-2 diabetes

There are 29 million U.S. adults diagnosed with diabetes and an additional 1 in 3 diagnosed as pre-diabetic. Diabetes is a serious disease which can result in serious health complications including nerve damage, vision loss, heart disease, and kidney failure, to name a few.

11 Nov 2014

UCSD researchers implicate new gene in idiopathic or non-syndromic autism

With the help of mouse models, induced pluripotent stem cells (iPSCs) and the "tooth fairy," researchers at the University of California, San Diego School of Medicine have implicated a new gene in idiopathic or non-syndromic autism. The gene is associated with Rett syndrome, a syndromic form of autism, suggesting that different types of autism spectrum disorder (ASD) may share similar molecular pathways.

11 Nov 2014

Researchers refine diagnostic tools to predict treatment outcomes for children with neuroblastoma

Oncology researchers studying gene mutations in the childhood cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibitors that target such mutations. Removing some of the guesswork in diagnosis and treatment, the researchers say, may lead to more successful outcomes for children with this often-deadly cancer.

11 Nov 2014

Protein News and Research

Further Reading

University of Leeds researchers make new synthetic anti-cancer molecule

U of G research may lead to novel treatment approaches for late-stage ovarian cancer

Study defines, establishes criteria for primary age-related tauopathy

Bevacizumab–erlotinib combined efficacy may depend on VEGF level

New NIH-funded study aims to find novel way to treat iron deficiency anemia in children

Study identifies genetic alterations that contribute to growth and recurrence of Ewing sarcoma

Novel method could improve treatment for infants, young children suffering from HIV/AIDS

Effecting changes to FosB gene could help control addiction, depression

Scientists identify new therapeutic targets, screening test to uncover compounds for memory disorders

RPCI researchers identify two novel candidate prognostic markers for ovarian cancer

Researchers identify key protein that can reduce severity of disease equivalent to MS in mice

Research finding could lead to new therapies for preventing growth of plexiform neurofibromas

New findings could help develop therapeutic options for glycogen storage disease

Stopping the death of synapses: an interview with Dr Soledad Galli

Five simple steps to reduce type-2 diabetes

UCSD researchers implicate new gene in idiopathic or non-syndromic autism

Researchers refine diagnostic tools to predict treatment outcomes for children with neuroblastoma

FDA accepts Amgen's evolocumab BLA for review

First steps in the origin of pancreatic cancer identified by Mayo Clinic researchers

Anxiety can accelerate conversion to Alzheimer's disease for people with mild cognitive impairment

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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