RNA Sequencing News and Research

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Research shows how Huntington’s disease affects two distinct cell populations in the striatum

In patients with Huntington's disease, neurons in a part of the brain called the striatum are among the hardest-hit.

20 Jan 2023

Longitudinal assessment of immunoglobulin G antibody responses to messenger ribonucleic acid vaccination doses and breakthrough infections

Researchers evaluated immunoglobulin G (IgG) responses to coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccinations.

20 Jan 2023

First-ever method for analyzing RNA sequencing data genome-wide using a 'pantranscriptome'

Analyzing a person's gene expression requires mapping their RNA landscape to a standard reference to gain insight into the degree to which genes are "turned on" and perform functions in the body.

16 Jan 2023

Machine learning tools help unravel why human accelerated regions evolved so quickly

Humans and chimpanzees differ in only one percent of their DNA. Human accelerated regions (HARs) are parts of the genome with an unexpected amount of these differences.

13 Jan 2023

Study reveals why older male fruit flies are more likely to pass mutations onto their offspring

The male reproductive system serves as a hotspot for the emergence of new genes. Perhaps that explains why more new mutations are inherited from fathers than from mothers.

12 Jan 2023

MALAT1 suppression is a hallmark of tissue and peripheral proliferative T cells in COVID-19

In a recent study posted to the medRxiv* preprint server, researchers in the United Kingdom investigated lncRNA (long non-coding ribonucleic acids) expression in coronavirus disease 2019 (COVID-19) T lymphocyte transcriptomes.

10 Jan 2023

Researchers develop new tool to isolate and analyze rare astrocyte regulators

Rare cell types can have an undue influence on human health. Previous research has suggested that a subset of astrocytes-;star-shaped cells in the brain and spinal cord-;may be responsible for multiple sclerosis (MS), a disease in which the immune system attacks the covering that protects nerves.

4 Jan 2023

Study shows the clinical utility of amniotic fluid cells RNA-sequencing in prenatal rare disease diagnosis

A clinical research team from the Department of Paediatrics and Adolescent Medicine and the Department of Obstetrics and Gynaecology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong (HKUMed) leads the discovery of applying amniotic fluid cells obtained during 16-24 weeks of pregnancy as a novel sample type for RNA-sequencing in prenatal diagnosis to help more families with tailored clinical management.

4 Jan 2023

Mouse study identifies potential targets for treating dry eye disease and corneal injury

People with a condition known as dry eye disease are more likely than those with healthy eyes to suffer injuries to their corneas.

2 Jan 2023

Scientists find key reason for ongoing loss of smell in long-COVID

In a recent study published in the journal Science Translational Medicine, researchers reported that long-term anosmia following coronavirus disease 2019 (COVID-19) could be a result of persistent T-cell mediated inflammation occurring in the olfactory epithelium even after the elimination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the olfactory tissue.

27 Dec 2022

Novel bacterial therapy approach opens up new treatment options for lung cancer patients

Lung cancer is the deadliest cancer in the United States and around the world. Many of the currently available therapies have been ineffective, leaving patients with very few options.

26 Dec 2022

Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children

Researchers assessed the inborn abnormalities of 2′-5′-oligoadenylate synthetase (OAS)-ribonuclease L (RNASEL) noted in coronavirus disease 2019 (COVID-19)-associated multisystem inflammatory syndrome in children (MIS-C).

23 Dec 2022

Study reveals why human lymph nodes lose their function with age

A new study from researchers at Uppsala University presents novel findings on why human lymph nodes lose their function with age and the consequences for the effectiveness of our immune system. The article has been published in The Journal of Pathology.

21 Dec 2022

Adding Gli1+ cells could regenerate the enthesis after rotator cuff surgery

In the annals of shoulder surgery, NFL quarterback Drew Brees is an anomaly. In 2005, Brees was tackled and the rotator cuff tendon in his throwing shoulder was severely torn, a potentially career-ending injury.

16 Dec 2022

Ceramide blockers prevent the loss of muscle mass during aging in mice

During aging, mice, like humans, become inactive and lose muscle mass and strength. A team of scientists led by Johan Auwerx at EPFL have now discovered that when mice age, their muscles become packed with ceramides.

16 Dec 2022

Researchers identify a new target gene in pancreatic ductal adenocarcinoma

Pancreatic cancer remains one of the deadliest malignancies worldwide. Since five-year survival rate for pancreatic ductal adenocarcinoma (PDAC) is only about 3% in patients, PDAC is very difficult to treat with surgery worldwide.

16 Dec 2022

How is the host’s m6A mRNA profile affected during SARS-CoV-2 infection?

Researchers observed that SARS-CoV-2 infection results in loss of N6-methyladenosine modification in cellular RNAs.

15 Dec 2022

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.

14 Dec 2022

Study uncovers a new immune culprit in Alzheimer’s disease

The reason your three-pound brain doesn't feel heavy is because it floats in a reservoir of cerebrospinal fluid (CSF), which flows in and around your brain and spinal cord.

13 Dec 2022

Georgia State brain researcher receives NIH grant to create a model for personalized cancer treatments

A brain researcher at Georgia State University has been awarded a five-year, $3.06 million grant from the National Cancer Institute at the National Institutes of Health to create a model for personalized cancer treatments.

8 Dec 2022

RNA Sequencing News and Research

Research shows how Huntington’s disease affects two distinct cell populations in the striatum

Longitudinal assessment of immunoglobulin G antibody responses to messenger ribonucleic acid vaccination doses and breakthrough infections

First-ever method for analyzing RNA sequencing data genome-wide using a 'pantranscriptome'

Machine learning tools help unravel why human accelerated regions evolved so quickly

Study reveals why older male fruit flies are more likely to pass mutations onto their offspring

MALAT1 suppression is a hallmark of tissue and peripheral proliferative T cells in COVID-19

Researchers develop new tool to isolate and analyze rare astrocyte regulators

Study shows the clinical utility of amniotic fluid cells RNA-sequencing in prenatal rare disease diagnosis

Mouse study identifies potential targets for treating dry eye disease and corneal injury

Scientists find key reason for ongoing loss of smell in long-COVID

Novel bacterial therapy approach opens up new treatment options for lung cancer patients

Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children

Study reveals why human lymph nodes lose their function with age

Adding Gli1+ cells could regenerate the enthesis after rotator cuff surgery

Ceramide blockers prevent the loss of muscle mass during aging in mice

Researchers identify a new target gene in pancreatic ductal adenocarcinoma

How is the host’s m6A mRNA profile affected during SARS-CoV-2 infection?

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Study uncovers a new immune culprit in Alzheimer’s disease

Georgia State brain researcher receives NIH grant to create a model for personalized cancer treatments

Sequencing & Genomics: Elevating Science and Healthcare eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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