Single cell genomics News and Research

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New computational approach improves characterization of cellular diversity

Researchers in the United States have developed a computational method called “weighted-nearest neighbor” (WNN) analysis that can significantly improve the ability to define cellular states across various biological contexts and data types.

13 Oct 2020

UChicago genomics researcher wins NIH Director's New Innovator Award

Oni Basu, PhD, an assistant professor of genetic medicine at the University of Chicago, has received the prestigious National Institutes of Health Director's New Innovator Award.

6 Oct 2020

Cellular and molecular map of the human heart could guide personalized medicine

Scientists have created a cellular and molecular map of the healthy human heart, to understand how this vital organ functions, and to shed light on what goes wrong in cardiovascular disease.

24 Sep 2020

Researchers discover key signaling pathway in the pathogenesis of Paget's disease

Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of poorly understood malignant skin cancers collectively known as Paget's disease.

26 Jun 2020

PKU-led team identifies potent neutralizing antibodies against SARS-CoV-2

A joint research team led by Sunney Xie, Director of Beijing Advanced Innovation Center for Genomics at Peking University has successfully identified multiple highly potent neutralizing antibodies against the novel coronavirus SARS-CoV-2, the causative virus of the respiratory disease COVID-19, from convalescent plasma by high-throughput single-cell sequencing.

28 May 2020

Study creates a new platform to study single-cell genomics of many diseases

Although advances in genetics and genomics reveal numerous disease-associated gene mutations, physicians and researchers still wrestle with the tricky challenge of linking those mutations to actual disease-causing processes.

22 Apr 2020

Genomic sequencing technique helps understand gut microbiota one cell at a time

A population of microorganisms living in our intestine, known as the gut microbiota, plays a crucial role in controlling our metabolism and reducing the risk of conditions such as obesity and diabetes.

9 Feb 2020

New technique holds promise in cancer research and science studies

A new technique reported this week in Science overcomes several limitations of typical high-throughput chemical screens conducted on cell samples. Such screens are commonly used to try to discover new cancer drugs, and in many other biomedical applications.

8 Dec 2019

New mathematical method to map cell regulatory networks

Faster results. Lower costs. Fewer cells. A new mathematical method developed by researchers at Cincinnati Children's and New York University may soon make it much easier to conduct more of the complex data analysis needed to drive advances in the exploding field of personalized medicine.

6 Mar 2019

Newly developed algorithms can predict and correct errors in single cell analyses

Modern technology makes it possible to sequence individual cells and to identify which genes are currently being expressed in each cell.

24 Jan 2019

Elegant, low-cost approach enhances single-cell RNA sequencing

Droplet microfluidics has revolutionized single-cell RNA sequencing, offering a low-cost, high-throughput method for single-cell genomics. However, this method has been limited in its ability to capture complete RNA transcription information.

20 Dec 2018

Cytokine levels could predict autoimmune reactions to cancer immunotherapy

The development of immunotherapy, which mobilizes the body's own immune system to destroy cancer cells, is one of the greatest advances in cancer treatment, but immunotherapy can cause harm to healthy tissue in some patients.

31 Oct 2018

Barcelona researchers win one of the most prestigious EU grants to study CLL

The European Research Council today announced the results of the 2018 Synergy Grants call for proposals. The aim of Synergy Grants is to address ambitious research questions that can only be answered by the coordinated work of a small group of two to four principal investigators and their teams, bringing together their complementary skills, knowledge and resources.

26 Oct 2018

Research team awarded $3.6 million to assess safety of genome editing

As genome editing technologies quickly advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. They are also bringing to light a number of challenges that need to be addressed before potential treatments can be widely used in patients.

11 Oct 2018

Engineering organoids from stem cells to model retina diseases

Gray Camp joined the Institute of Molecular and Clinical Ophthalmology Basel as Group Leader in Single Cell Genomics. His group will combine single-cell genomic tools and retina and cerebral "organoids" to explore the development of the human visual system.

28 Sep 2018

Researchers discover secret communication hotline between breast cancers and normal cells

Australian researchers have uncovered a secret communication hotline between breast cancers and the normal cells surrounding them. Importantly, the messages sent back and forth between the normal and tumour cells encourage the cancer to survive and to become more aggressive.

13 Aug 2018

Advances in Cell Lineage Analysis

Dr. Jan Phillip Junker discusses the applications of CRISPR-Cas9 in cell lineage analysis and the development of tomo-seq; a method to study the spatial organization of cells within whole organisms.

9 May 2018

TGen project to develop standard operating procedures for single-cell RNA sequencing

The Translational Genomics Research Institute today announced grant support from the Chan Zuckerberg Initiative donor advised fund, an advised fund of the Silicon Valley Community Foundation, that will help revolutionize how researchers identify the genetic source of diseases and how best to treat each patient.

17 Oct 2017

Columbia scientists receive grant from CZI to construct atlas of cells in human spinal cord

Scientists at Columbia's Zuckerman Institute today received a grant from the Chan Zuckerberg Initiative donor advised fund, an advised fund of the Silicon Valley Community Foundation, to construct an atlas of gene activity of all cells in the human spinal cord.

17 Oct 2017

Illumina and Bio‑Rad introduce first next-generation sequencing solution for single-cell analysis

Illumina, Inc. and Bio‑Rad Laboratories, Inc. today announced the launch of the Illumina Bio-Rad Single-Cell Sequencing Solution at the J.P. Morgan Healthcare Conference, San Francisco.

26 Jul 2017