Transcription Factors News and Research

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High-throughput ChIP analysis platform introduced in new technical article

Porvair Sciences, in conjunction with researchers at Swansea University (UK) have written a new technical article entitled 'Chromatrap® 96: a new solid-state platform for high-throughput Chromatin Immunoprecipitation (ChIP)'.

From Chromatrap® - Porvair Sciences Ltd 24 Sep 2014

MIT engineers find new strategy to combat superbugs

In recent years, new strains of bacteria have emerged that resist even the most powerful antibiotics. Each year, these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, infect more than 2 million people nationwide, and kill at least 23,000. Despite the urgent need for new treatments, scientists have discovered very few new classes of antibiotics in the past decade.

22 Sep 2014

Curie-Cancer, Inventiva launch Epicure project that aims to develop epigenetic targets for cancer

Curie-Cancer, the body responsible for developing Institut Curie’s industry partnership activities, and Inventiva, a drug discovery company that focuses on therapeutic approaches involving transcription factors and epigenetic targets, today announce the launch of the Epicure project, which has just received financial backing from France’s national research agency, the ANR [Agence Nationale pour la Recherche].

17 Sep 2014

Scientists identify developmental on-off switch for Streptomyces

Scientists have identified the developmental on-off switch for Streptomyces, a group of soil microbes that produce more than two-thirds of the world's naturally derived antibiotic medicines.

30 Aug 2014

Dartmouth researchers evaluate role of assortativity signature on robustness

Dartmouth researchers explored the type and number of connections in transcription factor networks (TFNs) to evaluate the role assortativity plays on robustness in a study published in PLOS Computational Biology in August.

30 Aug 2014

Researchers explore connections in TFNs to evaluate role assortativity plays on robustness

30 Aug 2014

UT Southwestern faculty awarded CPRIT grants to combat cancer

UT Southwestern Medical Center faculty have received 19 grants totaling more than $26 million from the Cancer Prevention and Research Institute of Texas to expand cancer screenings, investigate the effectiveness and viability for cancer therapies and radiation treatments, conduct research into cancer biology, and recruitment.

29 Aug 2014

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

How much is currently known about what happens in the developing brain that puts people at risk of schizophrenia?

11 Aug 2014

Altering the circadian rhythm: an interview with Dr. Doug Kojetin, The Scripps Research Institute

The circadian rhythm is affected by many different stimuli—such as sleep and light, which are the most broadly appreciated ways—but also eating— all of which can modulate, or change, important processes in our bodies such as temperature, production of hormones or other signalling small molecules, cellular regeneration, and others.

6 Aug 2014

Xbp1s protein plays key role in brain regions to regulate metabolism

A protein that controls when genes are switched on or off plays a key role in specific areas of the brain to regulate metabolism, UT Southwestern Medical Center researchers have found.

26 Jul 2014

Study identifies molecular mechanisms could lead to new therapies to treat obesity, diabetes

A protein that controls when genes are switched on or off plays a key role in specific areas of the brain to regulate metabolism, UT Southwestern Medical Center researchers have found.

25 Jul 2014

Researchers identify key explanation for why immune system unsuccessful in killing HIV virus

Our immune system contains CD8+ T cells which protect us from various diseases such as cancer and viruses. Some of them are specifically tasked with killing cells infected with the HIV virus - and researchers from Karolinska Institutet in Sweden, together with international colleagues, have for the first time identified a key explanation for why these cells are unsuccessful in their task.

18 Jul 2014

New genetic programs for taking blank-slate stem cells and turning them into human blood

The ability to reliably and safely make in the laboratory all of the different types of cells in human blood is one key step closer to reality.

14 Jul 2014

MEF2 gene: A potential therapeutic target to protect neuronal loss in Alzheimer's, Parkinson's

A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has identified a chemical "switch" that controls both the generation of new neurons from neural stem cells and the survival of existing nerve cells in the brain.

4 Jul 2014

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Pancreatic cancer tumors addicted to mutant Kras signaling for their growth and progression have a ready-made substitute to tap if they're ever forced to go cold-turkey on the mutant oncogene, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cell.

20 Jun 2014

Research provides unique insight into lncRNAs that regulate lung development

It's a long way from DNA to RNA to protein, and only about two percent of a person's genome is eventually converted into proteins.

19 Jun 2014

Tufts researchers gain new insight into protein associated with bipolar disorder

Researchers from Tufts have gained new insight into a protein associated with bipolar disorder. The study, published in the June 3 issue of Science Signaling, reveals that calcium channels in resting neurons activate the breakdown of Sp4, which belongs to a class of proteins called transcription factors that regulate gene expression.

12 Jun 2014

Transcription Factors News and Research

High-throughput ChIP analysis platform introduced in new technical article

MIT engineers find new strategy to combat superbugs

Curie-Cancer, Inventiva launch Epicure project that aims to develop epigenetic targets for cancer

Scientists identify developmental on-off switch for Streptomyces

Dartmouth researchers evaluate role of assortativity signature on robustness

Researchers explore connections in TFNs to evaluate role assortativity plays on robustness

UT Southwestern faculty awarded CPRIT grants to combat cancer

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

Altering the circadian rhythm: an interview with Dr. Doug Kojetin, The Scripps Research Institute

Xbp1s protein plays key role in brain regions to regulate metabolism

Study identifies molecular mechanisms could lead to new therapies to treat obesity, diabetes

Researchers identify key explanation for why immune system unsuccessful in killing HIV virus

New genetic programs for taking blank-slate stem cells and turning them into human blood

MEF2 gene: A potential therapeutic target to protect neuronal loss in Alzheimer's, Parkinson's

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Research provides unique insight into lncRNAs that regulate lung development

Tufts researchers gain new insight into protein associated with bipolar disorder

Cancer drug offers protection against thrombosis

Wistar findings suggest means of boosting initial immune response

TSRI develops accurate structural map of complex molecular machines in cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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