Two photon Microscopy News and Research

RSS

Two-photon microscopy (also known as two-photon fluorescence light microscopy) was invented in 1990 as a new method of imaging live cells and tissues in three-dimensions. Conventional fluorescence microscopy illuminates a specimen through the processes of excitation and emissions.

New 'micro-organ' within the immune system identified

For the first time in decades, researchers have identified a new 'micro-organ' within the immune system - and they say it's an important step towards understanding how to make better vaccines.

22 Aug 2018

Multidisciplinary Human-Focused Research

The work that we're doing in particular involves the development of better models of the human body. To do that, we need to put together cells, tissues, culture them in an artificial environment so that they feel as if they're inside the human body.

From Logos Biosystems 20 Jun 2018

New tool to track interactions among brain cells in action

It's a neuroscientist's dream: being able to track the millions of interactions among brain cells in animals that move about freely, behaving as they would under natural circumstances. New technology developed at The Rockefeller University represents a big step toward realizing that goal.

7 May 2018

Fluorescent dye could allow doctors to obtain better images of blood vessels, tissues

Fluorescence imaging is widely used for visualizing biological tissues such as the back of the eye, where signs of macular degeneration can be detected. It is also commonly used to image blood vessels during reconstructive surgery, allowing surgeons to make sure the vessels are properly connected.

9 Apr 2018

MIT engineers devise automated approach to monitor neurons

Recording electrical signals from inside a neuron in the living brain can reveal a great deal of information about that neuron's function and how it coordinates with other cells in the brain.

30 Aug 2017

New substance restores brain function in Alzheimer's animal model

The protein amyloid beta is believed to be the major cause of Alzheimer's disease. Substances that reduce the production of amyloid beta, such as BACE inhibitors, are therefore promising candidates for new drug treatments.

28 Jul 2017

Researchers visualize development of blood vessels in zebrafish embryos

For the first time, researchers have followed the development of blood vessels in zebrafish embryos without using any labels or contrast agents, which may disturb the biological processes under study.

30 Mar 2017

Study may signal major shift in understanding of how the cerebellum encodes information

It's the part of the brain that makes sure you cannot tickle yourself. The cerebellum, an apple-sized region near the base of the skull, senses that your own fingers are the ones trying to tickle, and cancels your usual response.

21 Mar 2017

Super-resolution fluorescence microscopy sheds light on brain’s molecular mechanism

Advances in microscopy techniques have often triggered important discoveries in the field of neuroscience, enabling vital insights in understanding the brain and promising new treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's.

29 Dec 2016

MUSC researchers harness cutting-edge technology to uncover new role for pericytes during stroke

Pericytes are the primary locus of matrix-mellaproteinase-9-dependent (MMP-9) capillary damage and blood leakage during ischemia, according to preclinical findings reported by Medical University of South Carolina investigators in an article published online on November 14, 2016 by The Journal of Neuroscience.

5 Dec 2016

Llama antibodies can detect cerebral lesions that characterize Alzheimer's disease

The major challenge facing physicians treating Alzheimer's is the ability to detect markers of the disease as early as possible. These markers, located in the brain, are difficult to access, hampering diagnosis.

4 Nov 2016

Transplanted embryonic nerve cells can support damaged areas of the brain

A new study shows that embryonic nerve cells can functionally integrate into local neural networks when transplanted into damaged areas of the visual cortex of adult mice.

27 Oct 2016

Researchers develop new technology to capture images of the brain

In a partnership melding neuroscience and electrical engineering, researchers from UNC-Chapel Hill and NC State University have developed a new technology that will allow neuroscientists to capture images of the brain almost 10 times larger than previously possible - helping them better understand the behavior of neurons in the brain.

28 Jun 2016

New light-based technique may offer improved treatment for eye problems

Researchers have developed a new light-based technique that selectively stiffens tissue in the cornea and might one day offer improved treatment for eye problems caused by weakened corneal tissue.

5 May 2016

Prior Scientific collaborates with Neurotar to produce in vivo microscopic imaging solution for neuroscientists

Prior Scientific reports that its collaboration with Neurotar has produced a seamlessly integrated solution for in vivo microscopic imaging in the brain of awake and moving rodents. The solution is based upon Prior’s ultra-stable and easily adjustable Z-Deck platform.

From Prior Scientific Instruments Ltd. 5 Apr 2016

Possible reasons found for Alzheimer’s treatment failure

Agglutinated proteins in the brain, known as amyloid-β plaques, are a key characteristic of Alzheimer’s. One treatment option uses special antibodies to break down these plaques.

10 Nov 2015

Researchers use fast-scanning PAM to see blood oxygenation, other functions inside living brain

Researchers studying cancer and other invasive diseases rely on high-resolution imaging to see tumors and other activity deep within the body's tissues. Using a new high-speed, high-resolution imaging method, Lihong Wang, PhD, and his team at Washington University in St. Louis were able to see blood flow, blood oxygenation, oxygen metabolism and other functions inside a living mouse brain at faster rates than ever before.

31 Mar 2015

The Brain Prize awarded to four scientists for development of two-photon microscopy

The world's most valuable (€1m) neuroscience prize, The Brain Prize has been awarded, to four scientists, Winfried Denk and Arthur Konnerth (Germany), and Karel Svoboda and David Tank (USA), for the invention and development of two-photon microscopy, a transformative tool in brain research.

9 Mar 2015

CUMC researcher develops new 3D microscope that can help view living things at very high speeds

Opening new doors for biomedical and neuroscience research, Elizabeth Hillman, associate professor of biomedical engineering at Columbia Engineering and of radiology at Columbia University Medical Center, has developed a new microscope that can image living things in 3D at very high speeds.

20 Jan 2015

$Scientists use TPF-SHG microscopy to study effects of micro-ablative fractional laser resurfacing$

Scientists use TPF-SHG microscopy to study effects of micro-ablative fractional laser resurfacing

Many people in the Western World consider it as a social need to hide the effects of aging. For this purpose, different cutaneous rejuvenation treatments have been developed, including a laser-based technique, known as laser resurfacing.

20 Nov 2014