The Viva columns are based on a wide pore material designed for optimal large-molecule separations. The commercial wide-pore silicas meet the standard 300 Å mean pore size, most have very broad distributions about this mean, with a significant portion of their pore volume falling below 150 Å. This means a large portion of the surface area is unavailable to larger molecules. Viva columns have a narrow distribution around the mean pore size, permitting a larger portion of the silica surface to play a role in the separation.
- Excellent for separating peptides or proteins.
- Rugged, spherical particles with 300 Å pore size.
- High proportion of pore/surface area available to large molecules.