ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

Soligenix announces personalized medicine collaboration with SciClone

Soligenix, Inc., a clinical stage biopharmaceutical company focused on developing products to treat inflammatory diseases and biodefense countermeasures where there remains an unmet medical need, announced a personalized medicine collaboration with SciClone Pharmaceuticals in the Company's oral mucositis clinical program with SGX942.

8 Jul 2013

Longer prescriptions after leaving hospital associated with long-term adherence in cardiac patients

Elderly cardiac patients prescribed heart medications for 60 days or more after leaving hospital have four times the odds of adhering to the drug regime than patients prescribed the same medications for 30 days, according to research conducted at the Institute for Clinical Evaluative Sciences and Women's College Hospital.

29 Jun 2013

Too much sugar can lead to heart failure, shows study

Too much sugar can set people down a pathway to heart failure, according to a study led by researchers at The University of Texas Health Science Center at Houston (UTHealth).

15 Jun 2013

New survey data reveal need for specialist nurse support in management of patients with heart failure

One year after the publication of the European Society of Cardiology (ESC) Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012, awareness amongst UK healthcare professionals varies dramatically.

6 Jun 2013

Coenzyme Q10 decreases all cause mortality by half in randomized double blind trial

Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress.

27 May 2013

AbbVie starts Phase 3 clinical study of atrasentan in patients with diabetic nephropathy

AbbVie announced today the initiation of a Phase 3 clinical study called SONAR (Study Of Diabetic Nephropathy with Atrasentan) to assess the effects of the investigational compound atrasentan - when added to standard of care - on progression of kidney disease in patients with stage 2 to 4 chronic kidney disease and type 2 diabetes.

21 May 2013

Unavoidable damage to heart and lungs can be limited by using CVD drug

Unavoidable damage caused to the heart and lungs by radiotherapy treatment of tumours in the chest region can be limited by the administration of an ACE inhibitor, a drug commonly used in the treatment of cardiovascular disease, a group of Dutch researchers have found.

23 Apr 2013

Study finds no evidence that digoxin increases mortality in patients with atrial fibrillation

A study published today in the European Heart Journal found no evidence that digoxin increases mortality in patients with atrial fibrillation, the opposite of results just published by another group in the same journal analyzing the same data.

17 Apr 2013

L-carnitine improves cardiac health in patients after heart attack, say researchers

L-carnitine significantly improves cardiac health in patients after a heart attack, say a multicenter team of investigators in a study published today in Mayo Clinic Proceedings.

15 Apr 2013

Aliskiren and standard therapy not associated with reduced CV death or HF rehospitalization

Among patients hospitalized for heart failure (HF) with reduced left ventricular ejection fraction (LVEF; a measure of how well the left ventricle of the heart pumps with each contraction), initiation of the medication aliskiren in addition to standard therapy did not reduce cardiovascular death or HF rehospitalization at 6 or 12 months after discharge, according to a study published online by JAMA.

12 Mar 2013

African-American women with breast cancer more likely to develop heart failure

African-American women who survive breast cancer are more likely to develop heart failure than other women who have beaten the disease, according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session.

8 Mar 2013

New Orleans residents continue to face increased risk of heart attack post-Katrina

New Orleans residents continue to face a three-fold increased risk of heart attack post-Katrina-a trend that has remained unchanged since the storm hit in 2005, according to research being presented at the American College of Cardiology's 62nd Annual Scientific Session.

7 Mar 2013

Benefits of diastolic function improvement in heart failure questioned

The importance of left ventricular diastolic function improvement in patients with heart failure with preserved ejection fraction has been questioned, after researchers found that treatment with spironolactone resulted in some functional improvements but failed to impact on patients’ exercise capacity.

5 Mar 2013

Morning, smooth ambulatory BP control ‘rarely achieved’ in general practice

Most patients receiving treatment for hypertension do not have their morning blood pressure levels controlled, and do not achieve smooth daytime control, researchers report.

18 Feb 2013

Ramipril puts spring in step of patients with intermittent claudication

Six months of treatment with the angiotensin-converting enzyme inhibitor ramipril produces notable improvements in the walking ability of patients with peripheral artery disease and intermittent claudication, shows a large randomized trial.

6 Feb 2013

Ramipril may improve pain-free walking among patients with PAD and intermittent claudication

Among patients with peripheral artery disease and intermittent claudication (pain in the calf that comes and goes, typically felt while walking), 24 weeks of treatment with the angiotensin-converting enzyme (ACE) inhibitor ramipril was associated with improvement in pain-free and maximum walking times and the physical health aspect of quality of life, according to a study appearing in the February 6 issue of JAMA.

6 Feb 2013

ACE Inhibitors News and Research

Further Reading

Soligenix announces personalized medicine collaboration with SciClone

Longer prescriptions after leaving hospital associated with long-term adherence in cardiac patients

Too much sugar can lead to heart failure, shows study

New survey data reveal need for specialist nurse support in management of patients with heart failure

Coenzyme Q10 decreases all cause mortality by half in randomized double blind trial

AbbVie starts Phase 3 clinical study of atrasentan in patients with diabetic nephropathy

Unavoidable damage to heart and lungs can be limited by using CVD drug

Study finds no evidence that digoxin increases mortality in patients with atrial fibrillation

L-carnitine improves cardiac health in patients after heart attack, say researchers

Aliskiren and standard therapy not associated with reduced CV death or HF rehospitalization

African-American women with breast cancer more likely to develop heart failure

New Orleans residents continue to face increased risk of heart attack post-Katrina

Benefits of diastolic function improvement in heart failure questioned

Morning, smooth ambulatory BP control ‘rarely achieved’ in general practice

Ramipril puts spring in step of patients with intermittent claudication

Ramipril may improve pain-free walking among patients with PAD and intermittent claudication

Dual renin angiotensin system blockade: too many cons

Hydrogen sulfide may play a wide-ranging role in staving off aging

German Research Foundation approves funding for Mainz study on cardiovascular disorders

Chronic heart failure treatment, Inspra (eplerenone), accepted for use within NHS Wales

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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