ACE Inhibitors News and Research

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ACE inhibitors act to reduce hypertension by interfering with the conversion of angiotensin I to artery-constricting angiotensin II. Blocking the production of angiotensin II results in arterial vasodilation and an accompanying reduction in blood pressure. ACE inhibitors currently are recommended as first-line therapy for hypertension in certain patient populations, because of their safety and efficacy.

Blacks less likely to get expensive, newer heart treatments

Blacks who suffer the most common type of cardiac ischemia – non-ST-elevation acute coronary syndrome – are less likely than whites to receive expensive or newer evidence-based treatments, according to a report in a special disparities themed issue of Circulation: Journal of the American Heart Association.

15 Mar 2005

Efforts to improve the quality of post-heart attack care working better for men than for women

Efforts to improve the quality of post-heart attack care in hospitals are working - but they appear to be working better for men than for women, new research shows.

9 Mar 2005

Beta-blockers can benefit patients with certain serious heart problems such as diastolic heart failure

Beta-blockers, medications that block the action of certain hormones on the heart, can benefit patients with certain serious heart problems such as diastolic heart failure, according to cardiologists at the Keck School of Medicine of the University of Southern California and Loma Linda University Medical Center.

7 Mar 2005

Implanted devices are giving cardiologists a new view of subtle changes in a key measurement of heart health

Implanted devices intended to optimize the cardiac function of patients with heart failure have provided new insights into which patients might be at higher risk of dying suddenly from their disease, according to researchers at Duke University Medical Center.

7 Mar 2005

Breakthrough noninvasive tool for early cardiovascular disease detection

Physicians and researchers now have access to a noninvasive fingertip test that can identify patients with the earliest stages of cardiovascular disease and replace testing that is done during angiography.

7 Mar 2005

FDA approves Atacand (candesartan cilexetil) for the treatment of heart failure

AstraZeneca today announced that the US Food and Drug Administration (FDA) has approved its angiotensin receptor blocker (ARB) Atacand (candesartan cilexetil) Tablets for the treatment of heart failure (NYHA class II-IV and ejection fraction less than or equal to 40%) to reduce the risk of death from cardiovascular causes and reduce hospitalizations for heart failure.

23 Feb 2005

Transient ischemic attack (TIA) patients receive less aggressive attention than those with stroke

Transient ischemic attack (TIA) patients receive less aggressive diagnostic testing, treatment and education compared to stroke patients, which is a missed opportunity to prevent permanent disability or death, researchers reported at the American Stroke Association's International Stroke Conference 2005.

3 Feb 2005

Drug reviparin reduces the risk of death after heart attack

The drug reviparin (a low molecular weight heparin anticoagulant), when administered to patients with a heart attack, is effective in reducing the risk of death and the risk of a subsequent heart attack, according to a study in the January 26 issue of JAMA.

26 Jan 2005

Low-dose diuretic therapy for most patients with hypertension recommended

Patients with high blood pressure who take calcium channel blockers and diuretics have an increased risk for cardiovascular disease (CVD) death compared to patients who take beta-blockers plus diuretics, according to a study in the current issue of JAMA.

16 Dec 2004

Noninvasive test of blood flow response may reveal early coronary disease

Chest pain patients who have abnormal coronary blood vessel function also have less responsive blood vessels in their fingertips, suggesting that a type of fingertip probe could become a useful screening tool, according to a new study in the Dec. 7, 2004 issue of the Journal of the American College of Cardiology.

8 Dec 2004

Startling new blood pressure findings - atherosclerosis slowed

A new study led by The Cleveland Clinic shows that giving blood pressure lowering medication to heart disease patients with a “normal” blood pressure dramatically reduces risk of adverse cardiac events and slows disease progression.

16 Nov 2004

Calcium channel blocker reduces adverse cardiovascular events

The calcium channel blocker amlodipine decreases the risk of cardiovascular events (such as heart attack or heart-disease related deaths) in patients with coronary artery disease and normal blood pressure, as does the ACE inhibitor enalapril, but to a lesser extent, according to a study in the November 10 issue of JAMA.

10 Nov 2004

ACE inhibitors not needed for many heart disease patients

Many heart disease patients who are already receiving state-of-the-art therapy do not benefit from additional treatment with angiotensin converting enzyme (ACE) inhibitors, according to results of a new study funded by the National Heart, Lung, and Blood Institute (NHLBI).

8 Nov 2004

Doctors must choose and manage implanted cardiac defibrillators patients carefully

Implanted devices that can shock a failing heart back into regular rhythm do an excellent job of keeping patients alive, two new University of Michigan studies find.

8 Nov 2004

One in four deaths among women with heart failure can be attributed to kidney problems

About one in four deaths among women with heart failure can be attributed to kidney problems, and more deaths are linked to renal insufficiency than to any other single risk factor, according to a new study in the Oct. 19, 2004 issue of the Journal of the American College of Cardiology.

18 Oct 2004

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease, according to a study published in the October 12 issue of Neurology, the scientific journal of the American Academy of Neurology.

11 Oct 2004

High blood pressure can effect many life activities, including sex

Despite its seeming invisibility, high blood pressure is dangerous, even deadly. Its effects can linger throughout many life activities, including sex.

29 Sep 2004

Celacade shown to reduce risk of death and hospitalization in patients with advanced chronic heart failure

Vasogen has announced that comprehensive results from the Company's phase II trial of Celacade (immune modulation therapy) in advanced chronic heart failure patients were published in the September 15 issue of the Journal of the American College of Cardiology (JACC).

16 Sep 2004

HHS enhances Medicare drug card program to help seniors

Health and Human Services Secretary Tommy G. Thompson today announced new measures to help seniors get the lowest price possible for their medicines by allowing them -- for the first time -- to compare prices for similar drugs used to treat common diseases such as high cholesterol or blood pressure.

15 Sep 2004

Ramipril reduces rate of sudden cardiac death and nonfatal cardiac arrest by 21 percent

Ramipril, a high blood pressure and heart failure drug, can reduce the rate of sudden cardiac death and nonfatal cardiac arrest by 21 percent in people at high risk for heart attack or stroke, according to a study reported in Circulation: Journal of the American Heart Association.

7 Sep 2004

ACE Inhibitors News and Research

Further Reading

Blacks less likely to get expensive, newer heart treatments

Efforts to improve the quality of post-heart attack care working better for men than for women

Beta-blockers can benefit patients with certain serious heart problems such as diastolic heart failure

Implanted devices are giving cardiologists a new view of subtle changes in a key measurement of heart health

Breakthrough noninvasive tool for early cardiovascular disease detection

FDA approves Atacand (candesartan cilexetil) for the treatment of heart failure

Transient ischemic attack (TIA) patients receive less aggressive attention than those with stroke

Drug reviparin reduces the risk of death after heart attack

Low-dose diuretic therapy for most patients with hypertension recommended

Noninvasive test of blood flow response may reveal early coronary disease

Startling new blood pressure findings - atherosclerosis slowed

Calcium channel blocker reduces adverse cardiovascular events

ACE inhibitors not needed for many heart disease patients

Doctors must choose and manage implanted cardiac defibrillators patients carefully

One in four deaths among women with heart failure can be attributed to kidney problems

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease

High blood pressure can effect many life activities, including sex

Celacade shown to reduce risk of death and hospitalization in patients with advanced chronic heart failure

HHS enhances Medicare drug card program to help seniors

Ramipril reduces rate of sudden cardiac death and nonfatal cardiac arrest by 21 percent

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