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How COVID-19 affects the female reproductive system

A new review in the Biology of Reproduction journal analyzed the relationship between the immune system and the female reproductive system while focusing on the effects of COVID-19-associated immune responses on the reproductive system. The study searched PubMed to identify peer-reviewed literature in English up to May 2022 and finally included 83 studies.

3 Oct 2022

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Researchers investigated the use of aminoadamantane nitrate compounds as anti-SARS-CoV-2 drugs.

3 Oct 2022

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Researchers evaluated the efficacy, immunogenicity, and safety of a novel SARS-CoV-2 linear deoxyribonucleic acid vaccine in ferret models delivered using intramuscular injection and electroporation.

3 Oct 2022

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

A recent Nature Reviews Immunology study has summarized the efficacy of neutralizing antibodies that target four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely, the receptor-binding domain (RBD) in the S1 subunit, the fusion peptide region in the S2 subunit, the stem helix region, and the N-terminal domain.

2 Oct 2022

Simple nasal wash can prevent hospitalization and deaths from COVID-19

Simple nasal washes with mild saline water can prevent hospitalization and deaths from COVID-19, if applied twice daily following a positive diagnosis, according to research led by the US-based Augusta University.

30 Sep 2022

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

A new study demonstrated the efficacy of a newly engineered angiotensin-converting enzyme 2 (ACE2) based immunoadhesin against Omicron and other SARS-CoV-2 VOCs.

30 Sep 2022

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Scientists have identified lucidenic acid A, one of the bioactive compounds of Ganoderma lucidum, as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host cell entry. The study has recently been published in the journal Food and Chemical Toxicology.

29 Sep 2022

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

A new study showed that SARS-CoV-2 Spike N-glycosylation patterns, intracellular lectins, and the associated molecular chaperones play crucial roles in the viral-host-cell invasion and function.

28 Sep 2022

Researchers computationally design immunogens to elicit antibodies against different SARS-CoV-2 variants

A recent study designed immunogens to induce antibodies against SARS-CoV-2 variants.

28 Sep 2022

Can the gut be an alternative route for SARS-CoV-2 entry?

Researchers reviewed the gut pathophysiology of SARS-CoV-2 infection.

28 Sep 2022

How the gut microbiome could affect COVID-19 severity

Researchers review the potential role of the gut microbiome in determining severe COVID-19.

27 Sep 2022

Italian scientists investigate whether stranded cetaceans show evidence of SARS-CoV-2 infection

A new study examines SARS-CoV-2 infection in stranded cetaceans found dead along the Italian coast.

27 Sep 2022

Natural product SSP derived from a Chinese herb may have broad antiviral activities against respiratory viral infections

A research team comprised of members of the School of Chinese Medicine, AIDS Institute, Department of Microbiology, School of Clinical Medicine and State Key Laboratory for Emerging Infectious Diseases, the LKS Faculty of Medicine, The University of Hong Kong (HKUMed) have discovered a natural product SSP derived from a Chinese herb Spatholobus Suberectus Dunnthat demonstrated broad antiviral activities against SARS-CoV-1, SARS-CoV-2, influenza, and HIV-1 as an entry blocker.

27 Sep 2022

How do clinical outcomes in patients infected with different Omicron subvariants differ?

Researchers compare the clinical outcomes, upper respiratory viral loads, and viral recovery of different SARS-CoV-2 Omicron subvariants on cell cultures.

27 Sep 2022

Specific N-glycans regulate the development and functional maturation of SARS-CoV-2 spike protein

If you're an avid reader of science news, you've probably heard of viral proteins such as the COVID-19 spike protein.

27 Sep 2022

Association of self-reported chronic fatigue and retinal microcirculation in post-COVID-19 syndrome patients

Researchers investigated the potential association between self-reported chronic fatigue and retinal microcirculation among post-COVID-19 syndrome patients.

27 Sep 2022

The antibody response against SARS-CoV-2 in patients pre- and post-infusion with commercial intravenous immunoglobulin products

Researchers comparatively evaluated antibody responses against SARS-CoV-2 among immunodeficient individuals pre- and post-intravenous immunoglobulin product infusions.

27 Sep 2022

What is the impact of SARS-CoV-2 infection on semen parameters and sex hormones?

A new study aimed to systematically review studies investigating sex hormones and semen parameters in COVID-19 patients to provide a better understanding and treatment approach.

27 Sep 2022

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cells models

In a recent study posted to the bioRxiv* preprint server, researchers in Australia explored the molecular mechanisms of the pulmonary and cardiac complications caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using human stem-cell-derived cardiac and lung cells.

27 Sep 2022

Researchers uncover a new way the immune system detects coronavirus infection

In a recent study posted to bioRxiv*, researchers in the United States demonstrated that the main protease (Mpro) of coronaviruses (CoVs) activates host inflammasome responses.

27 Sep 2022

ACE2 News and Research

How COVID-19 affects the female reproductive system

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

Simple nasal wash can prevent hospitalization and deaths from COVID-19

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

What is the role of N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 spike maturation?

Researchers computationally design immunogens to elicit antibodies against different SARS-CoV-2 variants

Can the gut be an alternative route for SARS-CoV-2 entry?

How the gut microbiome could affect COVID-19 severity

Italian scientists investigate whether stranded cetaceans show evidence of SARS-CoV-2 infection

Natural product SSP derived from a Chinese herb may have broad antiviral activities against respiratory viral infections

How do clinical outcomes in patients infected with different Omicron subvariants differ?

Specific N-glycans regulate the development and functional maturation of SARS-CoV-2 spike protein

Association of self-reported chronic fatigue and retinal microcirculation in post-COVID-19 syndrome patients

The antibody response against SARS-CoV-2 in patients pre- and post-infusion with commercial intravenous immunoglobulin products

What is the impact of SARS-CoV-2 infection on semen parameters and sex hormones?

Rational treatment strategies for SARS-CoV-2 derived from human pluripotent stem cells models

Researchers uncover a new way the immune system detects coronavirus infection

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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