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Cytokinetics initiates of phase II clinical trial for CK-1827452

Cytokinetics has announced the initiation of a Phase II clinical trials program evaluating CK-1827452, a novel cardiac myosin activator for the potential treatment of patients with either acutely decompensated or chronic heart failure.

15 Apr 2007

Scientists discover key player in embryonic muscle development

Muscle fibers are large cells that contain many nuclei. They begin, like all animal cells, as naive embryonic cells. These cells differentiate, producing intermediate cells called myoblasts that are now destined to become muscle.

12 Apr 2007

Cell structures exhibit novel behaviors, mimic red blood cells and liquid crystals

Researchers at the University of Pennsylvania and Yale University have manipulated the internal, structural components of cells, creating a set of simulated cellular structures with novel mechanical properties, including one that acts like a red blood cell and another that mimics the soft, elastic behavior commonly found in novel synthetic materials called liquid crystal elastomers.

11 Apr 2007

Researchers determine a critical factor in workings of proteins

Scientists know that a better understanding of how proteins bond could lead to more effective treatments for genetic disorders and other life-threatening conditions.

18 Feb 2007

Scientists find molecular cause for form of deafness

Scientists exploring the physics of hearing have found an underlying molecular cause for one form of deafness, and a conceptual connection between deafness and the organization of liquid crystals, which are used in flat-panel displays.

5 Feb 2007

Muscle protein myosin VI involved in the development of prostate cancer

Researchers at the Johns Hopkins Kimmel Cancer Center have for the first time implicated the muscle protein myosin VI in the development of prostate cancer and its spread.

8 Nov 2006

Mechanics of atherosclerosis

Atherosclerotic narrowing and hardening of coronary arteries typically appear first at vessel branches, and a study in the October issue of Cellular Signalling reports that the type of mechanical stretching found at those branches activates a cellular protein known to damage cells.

12 Jul 2006

New technique to speed discovery of drug targets in chemical genetics

Researchers at Fox Chase Cancer Center have developed a new technique to speed discovery of drug targets in chemical genetics. Fox Chase researcher Jeffrey R. Peterson, Ph.D., and his colleagues describe a new way to swiftly find the proteins targeted by small molecule inhibitors during high-throughput screening (HTS) experiments. The new work offers a critical solution to a common stumbling block in this booming field of drug discovery.

26 Apr 2006

Researchers develop system for observing nuclear motion

The cell is understood to be highly organized, with specialized areas for different functions and molecular motors shuttling components around.

18 Apr 2006

Yale researchers shed new light on the mechanism of nerve cell growth

Researchers at Yale shed new light on the mechanism of nerve cell growth by identifying novel functions for a molecular "motor" protein, myosin-II, according to an article in Nature Cell Biology.

20 Mar 2006

New understanding of the molecular genetics of successful fertilization

A new paper in the February 15th issue of Genes & Development lends novel insight into the cellular changes that occur in sperm while they reside in the female reproductive tract - providing a new understanding of the molecular genetics of successful fertilization.

14 Feb 2006

Myosin VI can act as molecular transporter

Myosin VI has been thought to be a monomer, but Park et al. show that full-length myosin VI can be a dimer, and can walk processively on actin. By increasing the concentration, a greater and greater fraction dimerizes in vitro, and walks processively on actin.

7 Feb 2006

Researchers identify protein essential for the maintenance of synapses

Nerve cells store and transmit information via special contact sites called synapses. Synapses also play a role in determining what we remember and what we forget.

18 Jan 2006

New model important step toward understanding the molecular basis of cell membrane mechanics

A human red blood cell is a dimpled ballerina, ceaselessly spinning, tumbling, bending, and squeezing through openings narrower than its width to dispense life-giving oxygen to every corner of the body.

24 Oct 2005

Scientists gain better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases

UCSD researchers stretched cells in a workout chamber the size of a credit card to gain a better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases.

24 Oct 2005

Method to count the absolute number of individual protein molecules inside a living cell

Yale researchers have reported a method to count the absolute number of individual protein molecules inside a living cell, and to measure accurately where they are located, two basic hurdles for studying biology quantitatively.

20 Oct 2005

20 percent of people with chronic hepatitis C who receive a liver transplant will develop advanced cirrhosis

A new study from the University of North Carolina at Chapel Hill School of Medicine may have found a way to identify those at greatest risk, thereby allowing doctors to decide who should receive treatment that could save the transplanted organ. The new findings appear in the October issue of the journal Liver Transplantation.

9 Oct 2005

Potential biomarker that could be used to predict who might develop hepatic fibrosis

Two new studies on Hepatitis C (HCV) patients who underwent liver transplants examined a potential biomarker that could be used to predict who might develop hepatic fibrosis, a formation of scar-like tissue that can lead to cirrhosis.

3 Oct 2005

New insights that advance the current model of protein motility and muscle contraction

Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction.

3 Oct 2005

Ubiquitin ligase Rnf6 may be involved in oncogenesis

In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons.

3 Oct 2005

Actin News and Research

Cytokinetics initiates of phase II clinical trial for CK-1827452

Scientists discover key player in embryonic muscle development

Cell structures exhibit novel behaviors, mimic red blood cells and liquid crystals

Researchers determine a critical factor in workings of proteins

Scientists find molecular cause for form of deafness

Muscle protein myosin VI involved in the development of prostate cancer

Mechanics of atherosclerosis

New technique to speed discovery of drug targets in chemical genetics

Researchers develop system for observing nuclear motion

Yale researchers shed new light on the mechanism of nerve cell growth

New understanding of the molecular genetics of successful fertilization

Myosin VI can act as molecular transporter

Researchers identify protein essential for the maintenance of synapses

New model important step toward understanding the molecular basis of cell membrane mechanics

Scientists gain better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases

Method to count the absolute number of individual protein molecules inside a living cell

20 percent of people with chronic hepatitis C who receive a liver transplant will develop advanced cirrhosis

Potential biomarker that could be used to predict who might develop hepatic fibrosis

New insights that advance the current model of protein motility and muscle contraction

Ubiquitin ligase Rnf6 may be involved in oncogenesis

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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