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Spike-specific memory B cells develop resilience to SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers explored the cross-reactivity, avidity, and kinetics of memory B-cells and serum antibodies in vaccinated and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals.

4 Oct 2022

New capsule tunnels through mucus in the GI tract to deliver large protein drugs

One reason that it's so difficult to deliver large protein drugs orally is that these drugs can't pass through the mucus barrier that lines the digestive tract.

28 Sep 2022

Study reveals key role of AKG/OXGR1 signaling pathway in maintaining male reproduction

Infertility is a global public health problem caused by genetic defects, lifestyle, nutrition, and factors affecting the local metabolism and microenvironment of the reproductive system.

26 Sep 2022

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG).

21 Sep 2022

Potential HIV vaccine component leads to strong protection in primates

To block infection from HIV, a successful vaccine will require a combination of ingredients, including at least three antibody targets and a substance that boosts immune responses.

9 Sep 2022

New substance boosts the effect of protein-based COVID-19 vaccines

Ironically, some vaccines need their own "boosters." Adding an ingredient called an adjuvant can help vaccines elicit a more robust immune response, better training the body to fight a pathogen.

1 Sep 2022

Updated guidelines on the Valneva SARS-CoV-2 vaccine

The WHO provides interim guidelines for the use of the Valneva vaccine.

23 Aug 2022

Novel member of a class of anti-diabetes drugs could help treat muscle wasting disease

Inflammatory myopathies can be challenging to treat, but a new study reports encouraging findings for patients with these debilitating conditions. Researchers from Japan have found that a novel member of a class of anti-diabetes drugs could be the key to treating patients with muscle wasting disease.

18 Aug 2022

Remdesivir activates urotensin II receptor and induces cardiomyocyte dysfunction

In newly released research, scientists assessed the cardiac effects of remdesivir.

12 Aug 2022

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Researchers described a novel protein subunit vaccine comprising the receptor-binding domain (RBD) of ancestral SARS-CoV-2 spike (S) protein, dimerized with an immunoglobulin (Ig)G1-fraction, crystallizable (Fc) domain.

11 Aug 2022

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Stimulator of interferon genes, or STING, helps regulate immune activation. Thus, drugs that activate STING are being tested as a form of cancer immunotherapy and for treating certain infections.

11 Aug 2022

TransCode and MD Anderson scientists collaborate to validate therapeutic and diagnostic candidates

The University of Texas MD Anderson Cancer Center and TransCode Therapeutics, Inc. today announced a strategic alliance to advance TransCode's pipeline of RNA-targeted oncology therapeutic and diagnostic candidates.

2 Aug 2022

Study shows efficacy and safety of cytisine as a smoking cessation therapy

Research published in the Journal of Thoracic Oncology shows cytisine may be a safe and effective smoking cessation therapy in lung cancer screening volunteers.

28 Jul 2022

Nasal spray highly effective against HIV and SARS-CoV-2 in animal models

The intranasal delivery of amph-protein vaccines is a potential approach to elicit a mucosal immune response against many infectious diseases.

26 Jul 2022

SARS-CoV-2 oral vaccine candidate found to induce neutralizing mucosal IgA

A new study reported the outcomes of a clinical trial evaluating the oral vaccine candidate against SARS-CoV-2 developed by Vaxart.

25 Jul 2022

Scientists identify papain-like protease inhibitor against COVID-19

In a new study, researchers identified a papain-like protease inhibitor for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

25 Jul 2022

Scientists explore SARS-CoV-2 spike protein and platelet-activating factor

Researchers assessed the association between platelet-activating factor (PAF) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein.

25 Jul 2022

Analyzing whether SARS-CoV-2 nucleocapsid and spike proteins stimulate dendritic or γδ T cells

Researchers showed that the SARS-CoV-2 nucleocapsid (N) and spike (S) proteins did not activate γδ T cells and dendritic cells (DCs).

18 Jul 2022

COVID-19 vaccination with bacterial peptide conjugated to receptor-binding domain elicits potent immune response

In a new study, researchers assessed the efficiency of immunization with a bacterial peptide conjugated to the SARS-CoV-2 receptor-binding domain against SARS-CoV-2 infection.

6 Jul 2022

What causes insomnia and how to treat it?

A new study evaluates the symptoms of insomnia and its treatment as reported by patients in primary care settings.

5 Jul 2022

Agonist News and Research

Spike-specific memory B cells develop resilience to SARS-CoV-2

New capsule tunnels through mucus in the GI tract to deliver large protein drugs

Study reveals key role of AKG/OXGR1 signaling pathway in maintaining male reproduction

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Potential HIV vaccine component leads to strong protection in primates

New substance boosts the effect of protein-based COVID-19 vaccines

Updated guidelines on the Valneva SARS-CoV-2 vaccine

Novel member of a class of anti-diabetes drugs could help treat muscle wasting disease

Remdesivir activates urotensin II receptor and induces cardiomyocyte dysfunction

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

TransCode and MD Anderson scientists collaborate to validate therapeutic and diagnostic candidates

Study shows efficacy and safety of cytisine as a smoking cessation therapy

Nasal spray highly effective against HIV and SARS-CoV-2 in animal models

SARS-CoV-2 oral vaccine candidate found to induce neutralizing mucosal IgA

Scientists identify papain-like protease inhibitor against COVID-19

Scientists explore SARS-CoV-2 spike protein and platelet-activating factor

Analyzing whether SARS-CoV-2 nucleocapsid and spike proteins stimulate dendritic or γδ T cells

COVID-19 vaccination with bacterial peptide conjugated to receptor-binding domain elicits potent immune response

What causes insomnia and how to treat it?

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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