Airway Inflammation News and Research

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Pharmaxis announces NDA filing for Aridol

Pharmaxis, Inc., a wholly owned subsidiary of Pharmaxis Ltd , an emerging respiratory specialty pharmaceutical company, announced today that it has filed a New Drug Application (NDA), electronically, with the U.S. Food and Drug Administration (FDA) for Aridol (mannitol bronchial challenge test).

3 Mar 2009

Discovery of gene that modifies severity of cystic fibrosis lung disease

Researchers at Wake Forest University Baptist Medical Center, and colleagues, have identified a gene that modifies the severity of lung disease in people with cystic fibrosis, a lethal genetic condition. The findings open the door to possible new targets for treatment, researchers say.

3 Mar 2009

Discovery of gene that modifies severity of cystic fibrosis lung disease

Researchers have discovered a gene that modifies the severity of lung disease in people with the lethal genetic condition, cystic fibrosis, pointing to possible new targets for treatment, according to a new study in Nature.

25 Feb 2009

Discovery of gene that modifies severity of cystic fibrosis lung disease

25 Feb 2009

Vicks VapoRub may create respiratory distress in young children

New research out of Wake Forest University Baptist Medical Center suggests that Vicks® VapoRub®, the popular menthol compound used to relieve symptoms of cough and congestion, may instead create respiratory distress in infants and small children.

13 Jan 2009

Warning about Vicks VapoRub

A warning has been issued about the popular cough and cold treatment Vicks VapoRub. Experts say it should not be used on children under 2 years of age.

13 Jan 2009

Nitric oxide monitoring does not help most children with asthma

The level of nitric oxide (NO) in an asthmatic's exhaled breath can portend worsening asthma symptoms, and may even signify an imminent attack linked to underlying airway inflammation.

7 Jan 2009

Visualizing asthma-causing immune cells at work

Immune cells known as eosinophils have a central role in causing asthma.

7 Nov 2008

Simple gene-based blood test, quicker, more accurate evaluation for cystic fibrosis

Researchers at National Jewish Health have identified a simple gene-based blood test that more accurately and quickly measures cystic fibrosis patients' response to therapy than current tests.

26 Oct 2008

Steroids aid recovery from pneumonia, UT Southwestern researchers say

Adding corticosteroids to traditional antimicrobial therapy might help people with pneumonia recover more quickly than with antibiotics alone, UT Southwestern Medical Center scientists have found.

14 Oct 2008

Inhibiting stress oxidant may be new therapy for COPD

The study "Oxidative Stress is an Important Component of Airway Inflammation in Mice Exposed to Cigarette Smoke or Lipopolysaccharide" investigates the inflammatory responses in oxidative stress-deficient mice exposed to cigarette smoke.

18 Apr 2008

Gene linked to inherited blood biomarker associated with asthma risk

Risk for developing asthma is linked to variants in a gene called CHI3L1, which can be measured by checking levels of an inherited blood protein regulated by that gene, according to new research sponsored by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.

11 Apr 2008

Asthma and smoker's lung: dry airways play a key role

Dry airways may not only play a central role in the development of the inherited lung disease cystic fibrosis, but also in much more common acquired chronic lung diseases such as asthma and smoker's lung, the cigarette smoke-induced chronic obstructive pulmonary disease (COPD).

8 Apr 2008

MedImmune advances clinical development of antibody targeting interleukin-9 in patients with asthma

MedImmune has announced that its clinical program studying an investigational treatment targeting interleukin-9 (IL-9) has advanced with the start of a new trial in patients with asthma.

19 Mar 2008

Low dose inhaled corticosteroids improve lung function in mild asthma patients

A study by the Woolcock Institute of Medical Research in Sydney is the first to demonstrate that in patients with very mild or well-controlled asthma, regular treatment with low dose ICS leads to significantly better day-to-day lung function.

11 Mar 2008

Scientists recreate rhinovirus infection in mice - hope of new asthma treatments

Scientists have been able to recreate rhinovirus infection, which is behind most common colds, in a small animal for the first time.

4 Feb 2008

Severe asthma may be a different form of the disease

A multi-center research project to investigate severe asthma has found a key physiological difference between severe and non-severe forms of the disease, a finding that could help explain why those with severe asthma do not respond well to treatment.

31 Jan 2008

Children with high nitric oxide levels may still breathe easy

Nitric oxide (NO) is a gas released by cells in the lungs. When a person with allergies and/or asthma experiences an inflamed airway, the inflammatory cells release more NO and the NO levels increase. Due to this fact, fractional concentration of exhaled NO (FeNO) is an increasingly used tool in the diagnosis and management of asthma in children and adults.

7 Jan 2008

Exposure to traffic pollution can lead to chronic effects in the respiratory health of children with asthma

Exposure to traffic pollution may increase respiratory problems and reduce lung volumes in children with asthma, according to researchers who studied the effects of road and traffic density on children's lung function and respiratory symptoms in the border town of Ciudad Juarez in Mexico.

17 Dec 2007

Inhaled immune system stimulant launches immune response in lungs to wipe out lethal infections

An inhaled immune system stimulant protects mice against lethal pneumococcal pneumonia and other deadly bacterial, viral and fungal infections of the lungs, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports at a major scientific meeting.

4 Dec 2007