Antibiotic News and Research

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Antibiotics are drugs used to treat infections caused by bacteria and other microorganisms.

Targanta Therapeutics presents preclinical data on Oritavancin against Clostridium difficile infection

Targanta Therapeutics Corporation has released the in vivo data from a preclinical study comparing the activity of its antibiotic drug candidate, oritavancin, to vancomycin in a hamster model of Clostridium difficile infection.

26 Oct 2008

Simple gene-based blood test, quicker, more accurate evaluation for cystic fibrosis

Researchers at National Jewish Health have identified a simple gene-based blood test that more accurately and quickly measures cystic fibrosis patients' response to therapy than current tests.

26 Oct 2008

Gates Foundation grant to help prevent deaths in Africa by improving antibiotic access

The Alliance for the Prudent Use of Antibiotics (APUA) has announced a $1.37 million grant from the Bill & Melinda Gates Foundation, to explore ways of reducing millions of preventable deaths from severe respiratory and diarrheal infections in Africa. This project was announced in conjunction with a colloquium at the annual ICAAC/IDSA meeting warning of increasing antibiotic resistance.

26 Oct 2008

Researchers downplay value of mandatory universal nasal screening of patients for MRSA

Three Virginia Commonwealth University epidemiologists are downplaying the value of mandatory universal nasal screening of patients for MRSA, arguing that proven, hospital-wide infection control practices can prevent more of the potentially fatal infections.

23 Oct 2008

Trius Therapeutics awarded $28 million to develop novel drugs targeting bacterial DNA Gyrase and Topoisomerase IV

Trius Therapeutics, Inc., today announced the award of a $28 million contract from the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health, for the development of novel antibiotics directed against multiple Gram-negative bacterial pathogens.

22 Oct 2008

Contact lenses are home to pathogenic amoebae

Contact lenses increase the risk of infection with pathogenic protozoa that can cause blindness. New research, published in the November issue of the Journal of Medical Microbiology, shows that a high percentage of contact lens cases in Tenerife are contaminated with Acanthamoeba that cannot be killed by normal contact lens solution.

20 Oct 2008

Better TB vaccine in the pipeline

Scientists in the U.S. believe they have a vaccine in the pipeline that offers better protection from tuberculosis (TB).

20 Oct 2008

Molecule stops DNA replication in its tracks

When a dividing cell duplicates its genetic material, a molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication.

19 Oct 2008

Genes that control cell death may play role in age-related hearing loss

Several genes that play a role in how our body's cells normally auto-destruct may play a role in age-related hearing loss, according to research published online in the journal Apoptosis - a journal devoted to the topic of cell suicide, or programmed cell death.

19 Oct 2008

Model against unnecessary use of antibiotics

Patients in intensive care units (ICU) are often administered antibiotics against ventilator-associated pneumonia, 'to be on the safe side'. Dutch researcher Stefan Visscher has developed a model that can quickly establish whether or not a patient has pneumonia. This can prevent unnecessary treatment with antibiotics.

15 Oct 2008

Free treatment program against Buruli ulcer in Cameroon not working

Researchers have found that the fight against Buruli ulcer, a tropical skin disease, has hit a bump in Central Cameroon. Even as organizations provide free-of charge hospitalization care, patients' economic and social costs are preventing and delaying the treatment. Their study results are published October 15 in the open-access journal PLoS Neglected Tropical Diseases.

14 Oct 2008

Steroids aid recovery from pneumonia, UT Southwestern researchers say

Adding corticosteroids to traditional antimicrobial therapy might help people with pneumonia recover more quickly than with antibiotics alone, UT Southwestern Medical Center scientists have found.

14 Oct 2008

Ultra-sensitive nanoprobes help tackle MRSA

This week Nature Nanotechnology journal (October 12th) reveals how scientists from the London Centre for Nanotechnology (LCN) at University College London are using a novel nanomechanical approach to investigate the workings of vancomycin, one of the few antibiotics that can be used to combat increasingly resistant infections such as methicillin-resistant Staphylococcus aureus (MRSA).

12 Oct 2008

Tuberculosis vaccine a step closer

Researchers at Aberystwyth University, following a number of years of investment by the Biotechnology and Biological Sciences Research Council (BBSRC), have licensed ground-breaking research to a non-profit product development partnership working to develop new, more effective vaccines against Tuberculosis (TB). This development will give hope that significantly better prevention and treatment of TB will be available within the next few years.

12 Oct 2008

Helicobacter pylori may help prevent adenocarcinoma, esophageal cancers

Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature. These bacteria, which are called Helicobacter pylori, live in the stomachs of humans.

6 Oct 2008

Simple blood test could help detect serious bacterial infections in babies

A simple blood test may help detect serious bacterial infections (SBIs) like urinary tract infections and blood stream infections in young infants who come to the emergency department (ED) with fevers that have no clear cause.

6 Oct 2008

Disinfectants can make bacteria resistant to treatment

Chemicals used in the environment to kill bacteria could be making them stronger, according to a paper published in the October issue of the journal Microbiology. Low levels of these chemicals, called biocides, can make the potentially lethal bacterium Staphylococcus aureus remove toxic chemicals from the cell even more efficiently, potentially making it resistant to being killed by some antibiotics.

6 Oct 2008

Advanced Life Sciences submits NDA for cethromycin in mild-to-moderate community acquired pneumonia

Advanced Life Sciences Holdings, Inc. has announced the submission of a new drug application (NDA) for cethromycin in mild-to-moderate community acquired pneumonia (CAP). Advanced Life Sciences also entered into debt and equity financing agreements to strengthen its balance sheet and help fund commitments associated with the NDA submission and pre-commercialization activities.

2 Oct 2008

New technology promises tests for diseases such as cancer in 15 minutes

Scientists at Leeds University in the UK say soon, testing for diseases such as cancer and multiple sclerosis, could take as little as 15 minutes and could be as simple as using a pregnancy testing kit.

1 Oct 2008