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CAR-T cell therapy remains viable for patients in lymphoma remission, study finds

A study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests that CAR-T immunotherapy remains a viable option for patients who have lymphoma that goes into remission before the cell therapy begins.

11 Dec 2023

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.

11 Dec 2023

New insights into the structures formed during antibody aggregation through 3D domain swapping

Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future drug development.

8 Dec 2023

Fused pancreatic cancer organoid system captures tumor heterogeneity and drug resistance

Pancreatic ductal adenocarcinoma (PDAC), that arises from pancreatic epithelial cells, is the most common form of pancreatic cancer, with a very high mortality rate.

7 Dec 2023

Repeated mRNA vaccines supercharge immune response against COVID-19, study finds

Study published in Nature Immunology reveals that repeated mRNA COVID-19 vaccinations enhance immune response, especially in previously infected individuals, leading to a diversified and increased number of immune cell clones and a stronger ability to combat various virus strains.

7 Dec 2023

Immunoregulatory nanomedicines for the prevention and treatment of respiratory diseases

Study explores immunoregulatory nanomedicines for respiratory infections, highlighting their potential in enhancing treatment outcomes and vaccine efficacy.

7 Dec 2023

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

7 Dec 2023

These programs put unused prescription drugs in the hands of patients in need

On a recent November evening, Angie Phoenix waited at a pharmacy here in Colorado's second-largest city to pick up prescription drugs to treat her high blood pressure and arm seizures.

6 Dec 2023

Are there racial and ethnic disparities in the use of novel hormonal therapy agents in men with advanced prostate cancer?

Researchers assessed ethnic and racial differences in novel hormonal therapy (NHT) use among advanced prostate cancer (PCa) patients.

6 Dec 2023

New mechanism revealed for how group A Streptococcus infection reduces type 1 diabetes risk

Researchers have discovered the novel mechanism that underlies a previously reported observation that infection by group A Streptococcus bacteria reduces the risk of later developing Type 1 diabetes.

5 Dec 2023

Novel mRNA vaccine GLB-COV2-043 shows high efficacy against COVID-19 variants in early trials

The safety, efficacy, and immunogenicity of a mRNA-based vaccine.

5 Dec 2023

CHOP researchers unlock 3D structure of crucial protein for cancer therapy

Chimeric Antigen Receptors (CARs) have opened up an exciting new field of therapeutic advancements for rare and difficult-to-treat cancers, as they have the ability to deliver targeted therapies that can kill tumor cells.

1 Dec 2023

New molecular rulers for super-resolution microscopy: A breakthrough in biological imaging

Latest super-resolution microscopy methods now achieve an optical resolution in the range of a few nanometers.

1 Dec 2023

Scientists uncover the mystery behind painless leishmaniasis lesions

For the first time, scientists have begun to figure out why the disfiguring skin lesions caused by cutaneous leishmaniasis don't hurt.

30 Nov 2023

New approach enhances CAR T-cell therapy for solid tumors

Immunotherapy using modified chimeric antigen receptor (CAR) T cells has greatly improved survival rates for pediatric patients with relapsed and recurrent leukemia.

30 Nov 2023

Study shines new light on pancreatic cancer and the immune system

Recent findings at Cold Spring Harbor Laboratory (CSHL) shine a new light on pancreatic cancer.

29 Nov 2023

Researchers make great strides in combating pneumococcal pneumonia

The global impact of the coronavirus pandemic has ignited a renewed focus on emerging and re-emerging infectious diseases.

28 Nov 2023

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

Dietary components that impact anti-tumor immunity.

28 Nov 2023

Researchers develop $1 cancer treatment using engineered bacteria

What if a single one-dollar dose could cure cancer?

27 Nov 2023

Novel method can detect contaminants in T-cell cultures within 24 hours

Researchers from Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT's research enterprise in Singapore, in collaboration with Singapore Centre for Environmental Life Sciences Engineering (SCELSE) and Massachusetts Institute of Technology (MIT), have developed a novel method capable of identifying contaminants in T-cell cultures within 24 hours.

27 Nov 2023

Antigen News and Research

CAR-T cell therapy remains viable for patients in lymphoma remission, study finds

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

New insights into the structures formed during antibody aggregation through 3D domain swapping

Fused pancreatic cancer organoid system captures tumor heterogeneity and drug resistance

Repeated mRNA vaccines supercharge immune response against COVID-19, study finds

Immunoregulatory nanomedicines for the prevention and treatment of respiratory diseases

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

These programs put unused prescription drugs in the hands of patients in need

Are there racial and ethnic disparities in the use of novel hormonal therapy agents in men with advanced prostate cancer?

New mechanism revealed for how group A Streptococcus infection reduces type 1 diabetes risk

Novel mRNA vaccine GLB-COV2-043 shows high efficacy against COVID-19 variants in early trials

CHOP researchers unlock 3D structure of crucial protein for cancer therapy

New molecular rulers for super-resolution microscopy: A breakthrough in biological imaging

Scientists uncover the mystery behind painless leishmaniasis lesions

New approach enhances CAR T-cell therapy for solid tumors

Study shines new light on pancreatic cancer and the immune system

Researchers make great strides in combating pneumococcal pneumonia

Study finds diet-derived trans-vaccenic acid boosts anti-tumor immunity

Researchers develop $1 cancer treatment using engineered bacteria

Novel method can detect contaminants in T-cell cultures within 24 hours

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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