Aromatase Inhibitor News and Research

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Aromatase Inhibitors are drugs that prevent the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy for postmenopausal women who have hormone-dependent breast cancer.

Aromatase inhibitors for treatment of advanced breast cancer in postmenopausal women

Aromatase inhibitors, a type of hormone therapy used to treat advanced breast cancer in postmenopausal women, result in a small but significant increase in overall survival when compared to other hormone treatments, according to a new systematic review of studies.

30 Jan 2007

Scientists discover how androgen plays a role in the development of prostate cancer

Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.

8 Nov 2006

Identifying breast cancer patients most likely to benefit from Aromatase Inhibitor Therapy after adjuvant radiation and Tamoxifen

While some breast cancer survivors could benefit from adding aromatase inhibitors to the standard five years of tamoxifen, a new study shows the additional therapy should be weighed carefully for each individual.

23 Oct 2006

Aromatase inhibitors improve survival of advanced breast cancer patients compared to tamoxifen

Aromatase inhibitors improve the survival of advanced breast cancer patients compared to standard hormone therapies like tamoxifen, a researchers report in the September 20 issue of the Journal of the National Cancer Institute.

19 Sep 2006

Basal tumours may originate from breast stem cells that have undergone genetic mishaps

Findings support previous speculation that breast stem cells, or very early descendents, are the cells from which basal tumours arise.

24 Jul 2006

Combination of anastrozole and a synthetic hormone called goserelin may slow male breast cancer growth

Medical oncologists across the nation want to know whether a certain drug combination can slow the progression of male breast cancer, a rare disease that often goes undiagnosed until it's in an advanced stage.

10 Jul 2006

Hormonal treatments reduce risk of cancer returning

Women diagnosed with breast cancer who carry a certain genetic mutation can have breast-sparing surgery but should consider hormonal treatments to reduce their risk of cancer returning.

6 Jun 2006

Nimesulide fights breast cancer by targeting key enzyme

A pain-killing medication appears to halt the production of an enzyme that is key to a common form of breast cancer, a new study using tissue cultures suggests.

16 Apr 2006

Researchers show how estrogen turns genes on and off during cancer progression

Ohio - A new study suggests that the hormone estrogen works in partnership with other proteins to activate or suppress gene activity in breast cancer cells.

2 Feb 2006

Warning of risk of from vaginal oestrogen

Breast cancer specialists from one of the UK's leading cancer centres cautioned doctors of the risks in prescribing vaginal oestrogen to breast cancer patients being treated with the new aromatase inhibiting drugs, anastrozole, letrozole and exemestane.

26 Jan 2006

New breast cancer drug Femara will save lives

Following the results of a worldwide study, U.S. regulators have given approval for the use of the drug Femara for women with early breast cancer directly after they have had surgery.

29 Dec 2005

A good year for breast cancer detection and treatment

It was a good year in women’s health, notably breast cancer treatment and detection. The December issue of Mayo Clinic Women’s HealthSource hails these important advances of 2005.

29 Dec 2005

Aromatase inhibitors may slow growth of lung cancer

A few years ago researchers discovered that, much like breast tumors, some lung tumors also thrive on estrogen. Now a medical student conducting research on a Howard Hughes Medical Institute (HHMI) fellowship and colleagues have managed to stop the growth of human lung cancer cells in mice with a class of breast cancer drugs called aromatase inhibitors.

15 Dec 2005

More good news - Femara helps prevent the return of breast cancer

In more good news for women suffering from breast cancer a study by the the Swiss drugmaker Novartis has shown that their drug Femara benefits women with hormone-sensitive early breast cancer.

14 Dec 2005

Majority of women with breast cancer do not need chemotherapy

Researchers are now saying that chemotherapy with drugs called aromatase inhibitors is unnecessary after lumpectomy, radiation and 5 years of Tamoxifen, for the vast majority of women with breast cancer.

19 Oct 2005

Researchers look at pharmacogenomics

When patients receive chemotherapy, 15 percent will have severe side effects while 85 percent will not - even though they're given the same relative dose.

28 Sep 2005

Letrozole following tamoxifen may benefit women with breast cancer

Switching to the drug letrozole following 5 years of treatment with tamoxifen reduces the risk of hormone-dependent breast cancer recurrence, but not overall survival, among postmenopausal women, according to a new study in the September 7 issue of the Journal of the National Cancer Institute.

7 Sep 2005

Recent evidence suggests caution in prescribing hormone therapy for breast cancer

One of the most effective new treatments for breast cancer is a hormone therapy. Aromatase inhibitors work by powerfully blocking the conversion of androgen precursors into estrogens, which lowers estradiol levels in the bloodstream and estrogen levels in peripheral tissues.

4 Sep 2005

Switching treatment to the drug anastrozole after two years of tamoxifen is beneficial for women with early breast cancer

Switching treatment to the drug anastrozole after two years of tamoxifen can improve eventfree survival for postmenopausal women with early breast cancer, concludes a study in this week’s issue of The Lancet.

4 Aug 2005

Approval sought for Femara in early post-surgery use

Approval is being sought in the U.S. and Europe, by Swiss drug makerNovartis, for its breast-cancer drug Femara to be used immediately after surgery to help older women fight tumours.

12 Jul 2005