Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

New research extensively explores 12 distinctive aging traits

In a recent article published in Cell, researchers proposed that 12 distinctive traits of aging are all inter-related.

5 Jan 2023

Study investigates a new mechanism of pyrethroid derivatives-moderated programmed cell death

A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, "The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies."

29 Dec 2022

Researchers identify a small number of 'cheating' cancer cells under hypoxia

Researchers at UConn Health, Yale, and Johns Hopkins have identified that some cancer cells can "cheat" through escaping constraints imposed by lack of oxygen, allowing the cancer cells to continue to grow.

16 Dec 2022

Research shows biological sex as a crucial factor in the effectiveness of anti-aging drugs

The effect of medicines on women and men can differ significantly. This also applies to the currently most promising anti-aging drug rapamycin, as researchers from the Max Planck Institute for Biology of Ageing in Cologne and University College London have now shown.

1 Dec 2022

Time-restricted eating may benefit Alzheimer's

In a recent study published in the Experimental Gerontology journal, researchers in the United States assessed the impact of time-restricted eating (TRE) on Alzheimer's disease (AD), cognitive decline, and sleep.

21 Nov 2022

Huntington's disease impairs autophagy in older patients

Huntington's disease, a fatal, inherited neurodegenerative condition, is caused by a genetic error present at birth, though its symptoms often don't begin until middle adulthood.

28 Oct 2022

Swine acute diarrhea syndrome coronavirus promotes replication by inducing autophagy

The swine acute diarrhea syndrome coronavirus promotes autophagy to maintain its replication inside host cells.

26 Oct 2022

Exploring new therapeutic targets and biomarkers for neurodegenerative disorders

In this interview, Dr. Shebna Massey discusses neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and more. She also discusses and explores new therapeutic targets and biomarkers for these diseases.

From Sino Biological Inc. 26 Oct 2022

Anthelmintic inhibits exacerbated inflammatory response related to COVID-19 in preclinical research

Experiments involving animals and human cells conducted at the University of São Paulo (USP) in Brazil suggest that niclosamide, an anthelmintic widely used against tapeworms, effectively inhibits SARS-CoV-2 replication as well as the exacerbated inflammatory response that leads to death in many patients with severe COVID-19.

21 Oct 2022

Advanced cryo-electron microscope reveals how poliovirus takes over human cells

For the first time, researchers at Umeå University, Sweden, can now show how the dreaded poliovirus behaves when it takes over an infected cell and tricks the cell into producing new virus particles.

12 Oct 2022

The effect of ORF3c, a SARS-CoV-2 accessory protein, on cellular innate immune responses, autophagy, and lung cell mitochondrial metabolism

Researchers explored the role of the ORF3c, a SARS-CoV-2 accessory protein not so extensively studied as yet.

7 Oct 2022

Study identifies a potential biological marker to help diagnose postpartum depression

A federally funded study led by Johns Hopkins Medicine researchers discovered that communication among cells is altered in pregnant women who go on to develop postpartum depression (PPD) after giving birth.

4 Oct 2022

SARS-CoV-2-encoded protein ameliorates neuromuscular degeneration in fly models of neurodegenerative diseases

Researchers explored the in vivo efficacy of SARS-CoV-2-encoded proteins against neuromuscular degeneration associated with ribosome stalling.

3 Oct 2022

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

In a new study, researchers performed a proteomic multiple-reaction monitoring analysis of 91 pre-selected proteins using the plasma samples of 156 healthcare workers (HCW) in the United Kingdom (UK).

30 Sep 2022

Study reveals the role of autophagy in competitive elimination of cancer cells

Elimination of transformed cells that can initiate cancer is necessary to maintain tissue integrity. In a new study, scientists from Tokyo University of Science show how this mechanism is regulated by the cellular process “autophagy.”

30 Sep 2022

How the gut microbiome could affect COVID-19 severity

Researchers review the potential role of the gut microbiome in determining severe COVID-19.

27 Sep 2022

Study identifies potential therapeutic targets for preventing aminoglycoside-induced hearing loss

Researchers at Indiana University School of Medicine are developing new ways to study why an antibiotic causes hair cell death and permanent hearing loss in people.

27 Sep 2022

Combination of three existing drugs extends survival in mouse models of lethal brain cancer

A Ludwig Cancer Research study has identified a combination of three existing drugs that significantly extends survival in mouse models of the lethal brain cancer glioblastoma multiforme (GBM).

20 Sep 2022

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Autophagy is a self-degradation process that cells use to remove unneeded or damaged components. There are several forms of autophagy, including macroautophagy, which is a bulk degradation system used to target materials in the cell's cytosol to organelles called lysosomes for enzymatic breakdown.

20 Sep 2022

Endogenous exosomes act as decoys for SARS-CoV-2

A recent study published in the journal PLoS Biology discussed exosomes as potential decoys for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

20 Sep 2022

Autophagy News and Research

Further Reading

New research extensively explores 12 distinctive aging traits

Study investigates a new mechanism of pyrethroid derivatives-moderated programmed cell death

Researchers identify a small number of 'cheating' cancer cells under hypoxia

Research shows biological sex as a crucial factor in the effectiveness of anti-aging drugs

Time-restricted eating may benefit Alzheimer's

Huntington's disease impairs autophagy in older patients

Swine acute diarrhea syndrome coronavirus promotes replication by inducing autophagy

Exploring new therapeutic targets and biomarkers for neurodegenerative disorders

Anthelmintic inhibits exacerbated inflammatory response related to COVID-19 in preclinical research

Advanced cryo-electron microscope reveals how poliovirus takes over human cells

The effect of ORF3c, a SARS-CoV-2 accessory protein, on cellular innate immune responses, autophagy, and lung cell mitochondrial metabolism

Study identifies a potential biological marker to help diagnose postpartum depression

SARS-CoV-2-encoded protein ameliorates neuromuscular degeneration in fly models of neurodegenerative diseases

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

Study reveals the role of autophagy in competitive elimination of cancer cells

How the gut microbiome could affect COVID-19 severity

Study identifies potential therapeutic targets for preventing aminoglycoside-induced hearing loss

Combination of three existing drugs extends survival in mouse models of lethal brain cancer

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Endogenous exosomes act as decoys for SARS-CoV-2

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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