Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Genetic variants linked to Parkinson's risk from pesticide exposure

A new UCLA Health study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson's disease.

25 Apr 2024

Mitochondrial depletion in axons linked to protein accumulation in neurodegenerative diseases

Researchers from Tokyo Metropolitan University have identified how proteins collect abnormally in neurons, a feature of neurodegenerative diseases like Alzheimer's.

22 Apr 2024

New research pinpoints key pathways in prostate cancer's vulnerability to ferroptosis

Review examines the role of ferroptosis, an iron-dependent form of cell death, in prostate cancer, exploring its underlying molecular mechanisms and potential for targeted therapeutic strategies.

17 Apr 2024

Understanding regulatory effects of miRNAs on myocardial cell injury after coronary microembolization

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Coronary microembolization (CME) occurs in patients with acute coronary syndrome and is caused primarily by atherosclerotic plaque rupture associated with surgery.

15 Apr 2024

Rare variants in the YKT6 gene cause new neurological disorder, study finds

A recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer.

1 Apr 2024

Exploring the link between prenatal nutrition and congenital craniofacial malformations

The complex development of craniofacial skeletal structures and improve treatments for congenital craniofacial malformations.

27 Mar 2024

ADSC-Exos enhance healing process of diabetic wounds, study finds

The increasing prevalence of diabetes worldwide has led to a rise in diabetic wounds, such as diabetic foot ulcers, which are challenging to treat and can result in amputation.

18 Mar 2024

Unraveling the complexities of muscle repair in diabetes: A call for targeted research and therapies

Review outlines the impact of diabetes on skeletal muscle regeneration, highlighting the need for focused research and innovative therapies to tackle this growing health issue.

17 Mar 2024

Researchers pioneer a novel approach to enhance diabetic wound healing

Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.

14 Mar 2024

Novel therapy harnesses stem cell-derived exosomes for diabetic wound healing

20 Feb 2024

Researchers develop novel nanomedicine loaded with genetic material to fight HIV

Society learned about the value of mRNA during the COVID-19 pandemic when we saw scientists and medical professionals harness its power to deliver a vaccine for the virus within a year.

20 Feb 2024

Canagliflozin reduces atherosclerosis and modulates inflammatory, oxidative pathways in mice

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at investigating the effect of canagliflozin (Cana) on atherosclerosis and further exploring its potential mechanism. ApoE−/− mice were fed a Western diet (WD) and randomly divided into a WD group and WD+Cana group.

19 Feb 2024

A high-protein diet and elevation in the amino acid leucine may contribute to buildup of plaque in arteries

Researchers conducted clinical studies on murine animals and humans to evaluate the impact of high protein intake on the amino acid-mammalian target of the rapamycin complex 1 autophagy signaling pathway.

19 Feb 2024

Magnesium's pivotal role in slowing aging's impact

Review highlights magnesium's critical role in mitigating aging hallmarks, including telomere attrition, genomic instability, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion, suggesting that maintaining adequate magnesium levels could support healthy aging.

13 Feb 2024

Olive oil's secret weapon against Alzheimer's: phenolic compounds

A comprehensive review in the International Journal of Molecular Sciences highlights the potential of extra-virgin olive oil and its phenolic compounds in preventing and treating Alzheimer's disease through various mechanisms, including reducing amyloid-beta accumulation and neuroinflammation.

12 Feb 2024

Drinkable, carbon monoxide-infused foam supercharges cancer therapy

Did smokers do better than non-smokers in a clinical trial for an experimental cancer treatment? That was the intriguing question that led University of Iowa researchers and their colleagues to develop a drinkable, carbon monoxide-infused foam that boosted the effectiveness of the therapy, known as autophagy inhibition, in mice and human cells.

12 Jan 2024

Study sheds light on how impaired autophagy can play a role in causing heart failure

A new study sheds light on how autophagy, the body's process for removing damaged cell parts, when impaired, can play a role in causing heart failure.

11 Jan 2024

SickKids scientists untangle cellular waste buildup in Zellweger Spectrum Disorder

For the first time, a research team at The Hospital for Sick Children (SickKids) has uncovered a way to potentially reduce the amount of toxic cellular waste accumulating in patients with Zellweger Spectrum Disorder (ZSD).

9 Jan 2024

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins-;and ultimately affect aging.

4 Jan 2024

Deciphering how amino acids control cell growth and autophagy in yeast

Amino acids are the building blocks of life. We obtain them from the food we eat, and the body uses them to make proteins, which in turn are used for growth, development, and a multitude of other functions.

21 Dec 2023