Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Breakthrough in acute myeloid leukemia treatment targets stem cells

Acute myeloid leukemia is one of the deadliest cancers. Leukemic stem cells responsible for the disease are highly resistant to treatment.

24 Jul 2024

Saffron: A golden remedy for modern health challenges

Review highlights saffron's potential in preventing and treating various human diseases through its bioactive compounds. Clinical and preclinical studies confirm saffron's benefits in conditions like maculopathy, depression, neurodegenerative diseases, and cancer.

21 Jul 2024

Fungal endophytes: A promising frontier for breast cancer treatment

A recent study in Heliyon highlights the potential of fungal endophytes in developing novel anti-cancer agents, specifically targeting breast cancer therapy.

10 Jul 2024

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

The impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways.

5 Jul 2024

Study finds promising new target for the treatment of Alzheimer's disease

A class of proteins that regulates cell repair and enhances cell growth-signaling systems could be a promising new target for the treatment of Alzheimer's and other neurodegenerative diseases, according to a new study led by researchers at Penn State.

2 Jul 2024

New insights into signaling pathways and resistance mechanisms in colorectal cancer

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. The complexity of its pathogenesis, involving genetic mutations, dysregulated signaling pathways, and compromised immune surveillance, presents significant challenges for effective treatment.

21 Jun 2024

Interdisciplinary team reveals how Porphyromonas gingivalis interferes with chemotherapy-induced mitophagy

A new paper from an interdisciplinary team at MUSC Hollings Cancer Center describes how the bacteria Porphyromonas gingivalis interferes with chemotherapy-induced mitophagy, allowing oral cancer tumors to become resistant to the drug's effects.

18 Jun 2024

Mitophagy fuels cancer stem cell growth and survival

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, "Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration."

18 Jun 2024

New therapeutic approach for Duchenne muscular dystrophy combines LED therapy with idebenone

In an animal model of Duchenne muscular dystrophy, Brazilian researchers tested a therapy that combines photobiomodulation using laser light or light-emitting diodes (LEDs) with idebenone, an antioxidant compound investigated for application in neurodegenerative diseases.

14 Jun 2024

New biological mechanism uncovered for treating breast cancer metastasis to the brain

A study led by researchers from the University of Arizona Cancer Center at UArizona Health Sciences identified a biological mechanism that could lead to more effective treatments for breast cancer that has metastasized to the brain.

7 Jun 2024

Proteomic fitness scores revolutionize disease prediction and personalized exercise plans

Research establishes a proteomic CRF score, linking it to improved prediction of mortality and multisystem disease risks, showing dynamic response to exercise training.

5 Jun 2024

Omega-3 supplements show promise in battling osteoarthritis

A recent study in Nutrients reviewed the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in slowing the progression of osteoarthritis (OA) by reducing inflammation and supporting joint health.

2 Jun 2024

Evaluating the efficacy of harmol in treating herpes simplex virus-induced keratitis

The antiviral efficacy and therapeutic potential of harmol in treating herpes simplex virus type 1 (HSV-1) induced keratitis

29 May 2024

Genetic link identified between inflammatory bowel disease and Parkinson's disease

The researchers found, as expected from prior studies that LRRK2 is associated with IBD-PD and discovered new associations as well.

15 May 2024

Unraveling the genetic connection between IBD and Parkinson's disease

Researchers at the Icahn School of Medicine at Mount Sinai have made a significant discovery, identifying genetic connections between inflammatory bowel disease (IBD) and Parkinson's disease (PD).

14 May 2024

New insights into Chaga mushroom's mechanisms for fighting oral cancer

The mechanisms behind the anti-tumor activity of Chaga mushroom extracts in HSC-4 human oral cancer cells.

13 May 2024

Study provides deeper understanding of how membrane remodeling works in human cells

In a study published in the prestigious scientific journal PNAS, Umeå researchers describe a natural product-like molecule, Tantalosin, that inhibits interaction between two proteins in complexes that reshape membranes inside the cell.

3 May 2024

Research highlights the link between mitochondrial calcium transport and autophagy

An article published in The Faseb Journal describes a Brazilian study analyzing the correlation between two key energy metabolism regulation processes: the absorption and release of calcium ions by mitochondria, the organelles that generate energy for cells; and autophagy induced by calorie restriction. Autophagy occurs when cells break down and reuse their own cytoplasm.

2 May 2024

Study links agricultural pesticide exposure to increased genetic variants in Parkinson’s disease

Genetic characteristics that influence the risk of Parkinson's disease (PD) due to pesticide exposure.

1 May 2024

SCA4 genetic breakthrough: Unveiling the cause of a devastating neurological disease

Some families call it a trial of faith. Others just call it a curse. The progressive neurological disease known as spinocerebellar ataxia 4 (SCA4) is a rare condition, but its effects on patients and their families can be severe.

29 Apr 2024