Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

FOXO3 transcription factor may protect against alcohol-induced liver injury

New data suggest that the transcription factor FOXO3 may protect against alcohol-induced liver injury. Researchers determined that alcohol given to mice deficient in FOXO3 caused severe liver injury resembling human alcoholic hepatitis.

11 Nov 2013

Peptide from cow's milk exhibits potent anticancer capability against human stomach cancer cell cultures

New research from a team of researchers in Taiwan indicates that a peptide fragment derived from cow's milk, known as lactoferricin B25 (LFcinB25), exhibited potent anticancer capability against human stomach cancer cell cultures.

8 Nov 2013

Lactoferricin B25 derived from cow's milk shows promise for treatment of gastric cancer

8 Nov 2013

New drug combination therapy effectively kills cancer cells

Results from a recent preclinical study have shown that a new drug combination therapy being developed at Virginia Commonwealth University Massey Cancer Center effectively killed colon, liver, lung, kidney, breast and brain cancer cells while having little effect on noncancerous cells. The results lay the foundation for researchers to plan a future phase 1 clinical trial to test the safety of the therapy in a small group of patients.

6 Nov 2013

Linkam Scientific Instruments report the use of CMS196 for the imaging of mammalian cells at the London Research Institute, Cancer Research UK

Market leaders in temperature controlled microscopy, Linkam Scientific Instruments report on the use of their innovative CMS196 cryo stage for the study of mammalian cells at the London Research Institute, Cancer Research UK.

From Linkam Scientific Instruments 5 Nov 2013

Obesity suppresses important cellular process that prevents kidney cell damage

Obesity increases a chronic kidney disease patient's risk of developing kidney failure. Obesity suppresses an important cellular process that prevents kidney cell damage, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

7 Oct 2013

Individuals diagnosed with ASD more likely to have gene deletions, shows analysis

Using powerful genetic sequencing technology, a team of investigators, led by researchers at the Icahn School of Medicine at Mount Sinai, scanned the genome of hundreds of individuals, and discovered those diagnosed with autism spectrum disorder (ASD) were more likely to have gene deletions than were people without the disorder.

4 Oct 2013

Obesity suppresses important cellular process that prevents kidney cell damage

Obesity suppresses an important cellular process that prevents kidney cell damage, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest that restoring the process could protect the kidney health of obese individuals.

4 Oct 2013

Specialized cells play major role in inflammation that underlies Crohn's disease in small intestine

Scientists have discovered that Crohn's disease, the inflammatory bowel disorder, can originate from specialised intestinal cell type called Paneth cells. As such, they propose that small intestinal Crohn's disease might be a specific disorder of this cell type, providing a possible new target for treatments.

3 Oct 2013

Pitt scientists open door to potential research into cures for Parkinson's disease

A mix of serendipity and dogged laboratory work allowed a diverse team of University of Pittsburgh scientists to report in the Oct. 1 issue of Nature Cell Biology that they had solved the mystery of a basic biological function essential to cellular health.

1 Oct 2013

New regulatory mechanism could help develop novel therapies for cancer

Molecular microbiologists at the University of Southern California (USC) have uncovered intricate regulatory mechanisms within the cell that could lead to novel therapeutics for the treatment of cancer and other diseases.

23 Sep 2013

Overactivity of EGFR protein leads to heightened cancer growth and chemotherapy resistance

Overactivity of a protein that normally cues cells to divide sabotages the body-s natural cellular recycling process, leading to heightened cancer growth and chemotherapy resistance, UT Southwestern Medical Center researchers have found.

19 Sep 2013

Protein plays important role in process of degradation of tumour cells, say researchers

When tumour cells no longer degrade themselves, cancer may develop. Using black skin cancer as an example, Bern Researchers have now shown that a protein plays an important role in the process of degradation of tumour cells. By reactivating this degradation therapeutically, you can virtually force tumours to digest themselves.

12 Sep 2013

Disease Twofer: Parkin Problem Leads To Parkinson’S And Impairs Response To TB

University of California, San Francisco researchers report that a key protein associated with Parkinson's disease also plays a major role in the destruction of the bacteria that cause tuberculosis.

5 Sep 2013

Parkin protein plays key role in destruction of bacteria that cause tuberculosis

A protein at the center of Parkinson's disease research now also has been found to play a key role in causing the destruction of bacteria that cause tuberculosis, according to scientists led by UC San Francisco microbiologist and tuberculosis expert Jeffery Cox, PhD.

5 Sep 2013

Researchers identify possible treatment strategy for ALS and other neurodegenerative disorders

Researchers have tied mutations in a gene that causes amyotrophic lateral sclerosis and other neurodegenerative disorders to the toxic buildup of certain proteins and related molecules in cells, including neurons. The research, published recently in the scientific journal Cell, offers a new approach for developing treatments against these devastating diseases.

29 Aug 2013

Seven researchers to receive grants from ASTRO to advance radiation oncology research

The American Society for Radiation Oncology (ASTRO) has selected seven (7) leading researchers who will receive a total of $675,000 in awards and grants to advance radiation oncology research.

23 Aug 2013

Medical investigators discover new aspect of gene-splicing process that produces mRNA

A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his team from the Perelman School of Medicine at the University of Pennsylvania, discovered an entirely new aspect of the gene-splicing process that produces messenger RNA (mRNA).

22 Aug 2013

AMD associated with impaired lysosomal autophagy, study finds

A new study published in the prestigious PLoS One journal changes our understanding of the pathogenesis of age-related macular degeneration. The researchers found that degenerative changes and loss of vision are caused by impaired function of the lysosomal clean-up mechanism, or autophagy, in the fundus of the eye.

22 Aug 2013

Scientists develop new therapies to prevent chemoresistance of established tumours

Cancer cells often develop defence mechanisms which enable them to survive chemotherapy. A group of researchers from the Institutes of Pharmacology and Pathology in Bern present new solutions for preventing the development of such resistances.

17 Aug 2013

Autophagy News and Research

Further Reading

FOXO3 transcription factor may protect against alcohol-induced liver injury

Peptide from cow's milk exhibits potent anticancer capability against human stomach cancer cell cultures

Lactoferricin B25 derived from cow's milk shows promise for treatment of gastric cancer

New drug combination therapy effectively kills cancer cells

Linkam Scientific Instruments report the use of CMS196 for the imaging of mammalian cells at the London Research Institute, Cancer Research UK

Obesity suppresses important cellular process that prevents kidney cell damage

Individuals diagnosed with ASD more likely to have gene deletions, shows analysis

Obesity suppresses important cellular process that prevents kidney cell damage

Specialized cells play major role in inflammation that underlies Crohn's disease in small intestine

Pitt scientists open door to potential research into cures for Parkinson's disease

New regulatory mechanism could help develop novel therapies for cancer

Overactivity of EGFR protein leads to heightened cancer growth and chemotherapy resistance

Protein plays important role in process of degradation of tumour cells, say researchers

Disease Twofer: Parkin Problem Leads To Parkinson’S And Impairs Response To TB

Parkin protein plays key role in destruction of bacteria that cause tuberculosis

Researchers identify possible treatment strategy for ALS and other neurodegenerative disorders

Seven researchers to receive grants from ASTRO to advance radiation oncology research

Medical investigators discover new aspect of gene-splicing process that produces mRNA

AMD associated with impaired lysosomal autophagy, study finds

Scientists develop new therapies to prevent chemoresistance of established tumours

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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