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Caspase-12 antagonists could potentially be useful in the treatment of sepsis and other inflammatory and immune disorders

According to the new study, the presence of caspase-12, which appears to modulate inflammation and innate immunity in humans, increases the body's "vulnerability to bacterial infection and septic shock" while a deficiency confers strong resistance to sepsis. This new discovery suggests that caspase-12 antagonists could be a potentially useful in the treatment of sepsis and other inflammatory and immune disorders.

26 Apr 2006

Anthrax killed by protein that explodes cell walls

Not all biological weapons are created equal. They are separated into categories A through C, category A biological agents being the scariest: They are easy to spread, kill effectively and call for special actions by the pubic health system. One of these worrisome organisms is anthrax, which has already received its fair share of media attention. But work in Vince Fischetti's laboratory at Rockefeller University suggests that a newly discovered protein could be used to fight anthrax infections and even decontaminate areas in which anthrax spores have been released.

26 Apr 2006

Novel approach used to neutralize anthrax toxin

Researchers from Rensselaer Polytechnic Institute and the University of Toronto have designed a nanoscale assembly of molecules that successfully counteracts and inhibits anthrax toxin in animal and laboratory experiments.

23 Apr 2006

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

A team of scientists from Lawrence Berkeley National Laboratory and the Scripps Research Institute has determined the crystal structure and molecular mechanisms of a key part of WRN, a protein that protects humans from premature aging and cancer.

23 Apr 2006

Australian scientists tackle deadly Q fever

Scientists at James Cook University have taken the lead in developing a new vaccine against a highly infectious cattleyard disease caused by a bacteria which has the potential to be developed as a bioterrorist weapon.

20 Apr 2006

Bubonic plague confirmed in Los Angeles woman

Los Angeles County health officials have confirmed a case of bubonic plague in an adult woman. This is the first human case of plague in a Los Angeles County resident since 1984.

19 Apr 2006

New finding provides researchers with renewable source for macrophages and neutrophils

A new approach to generating large quantities of two types of white blood cells that are critical for destroying invading bacteria, viruses and other pathogens in humans has been developed by researchers at the University of California, San Diego (UCSD) School of Medicine.

19 Apr 2006

Tongue scraping for treating halitosis

Despite widespread use of mouthwashes, breath mints, sprays, chewing gums and mechanical tongue cleaning, research is inconclusive about which method is most effective at attacking bad breath, investigators conclude in a new review of clinical studies.

18 Apr 2006

miR 155 overexpression can lead to cancer

Scientists in the Ohio State University Comprehensive Cancer Center say that just one, single, malfunctioning microRNA is sufficient to cause cancer in mice.

18 Apr 2006

Less antibiotic use in food animals leads to less drug resistance in people

Australia's policy of restricting antibiotic use in food-producing animals may be linked with lower levels of drug-resistant bacteria found in its citizens, according to an article in the May 15 issue of Clinical Infectious Diseases.

18 Apr 2006

217 new targets for anti-cancer drugs

By identifying novel genes critical to cancer progression, biologists at the U.S. Department of Energy's Argonne National Laboratory have expanded the number of drug targets researchers have available for study to find ways to stop tumors in their tracks.

18 Apr 2006

Telithromycin antibiotic may help reduce some symptoms of a bad asthma attack

The researchers however believe the positive effects of the drug may be as a result of its impact on two bacteria - Chlamydophila pneumoniae and Mycoplasma pneumoniae - found present in 61% of patients in the study.

13 Apr 2006

Cheap way to produce expensive malaria drug well on the way

U.S. researchers say a cheap way to produce an expensive but effective malaria drug is well on the way.

13 Apr 2006

Antibiotic telithromycin is effective at treating acute asthma attacks

Researchers have demonstrated that an antibiotic is effective at treating acute asthma attacks, potentially providing a new way to help asthma sufferers.

13 Apr 2006

Proteomic mass spectrometry helps identify viruses

Scientists have used mass spectrometry for decades to determine the chemical composition of samples but rarely has it been used to identify viruses, and never in complex environmental samples.

13 Apr 2006

Compounds derived from legume interaction with rhizobium bacteria may help cancer treatment

The ARC Centre of Excellence for Integrative Legume Research (CILR) has lodged a complete patent application for compounds to treat cancer.

13 Apr 2006

FDA investigates abortion pill death

It seems that since the FDA approved the use of the abortion pill RU-486, (Mifeprex/ mifepristone) in September 2000, six women in the U.S. have died.

12 Apr 2006

Researchers determine factors that turn on protein production in bacteria

In the study, published in the journal Molecular Cell, researchers Sean Studer and Simpson Joseph in UCSD's Department of Chemistry and Biochemistry report how the messenger RNA instructions to make a protein are unfolded in a bacterial cell, so that they can be read by the cell's protein-making machinery.

11 Apr 2006

Streptococcal toxic shock syndrome caused by Streptococcus suis Serotype 2

Last year, there was major press coverage of an alarmingly large and deadly outbreak of Streptococcus suis disease in Sichuan province in China.

11 Apr 2006

New discovery could help improve some forms of chemotherapy

The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action that is critical to transcription and nucleotide excision repair (NER), as well as other cell processes.

11 Apr 2006