Biochemistry News and Research

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Massive gene screening points way to more effective chemotherapy

Using a technology that can quickly screen all 20,000-plus human genes for biological activity, scientists have isolated 87 genes that seem to affect how sensitive human cancer cells are to certain chemotherapy drugs.

12 Apr 2007

How auxin regulates TIR1 in plants provides clues to new treatments for human diseases

For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a plant hormone -- auxin -- interacts with its hormone receptor, called TIR1.

5 Apr 2007

UT Metroplex institutions to collaborate on biomedical research

Researchers from the three University of Texas campuses in the Dallas-Fort Worth metropolitan area are combining their expertise in biomedical science, engineering and physical sciences on projects aimed at solving real-world medical problems.

5 Apr 2007

New 'platform' for processing dietary fat discovered

A new "platform" with a crucial role in the body's ability to process and take up fat from the diet has been found, according to a report in the April issue of the journal Cell Metabolism, published by Cell Press.

3 Apr 2007

Researchers spot molecular player in insulin resistance and type 2 diabetes

Scientists at Weill Cornell Medical College have identified a protein called Rab10 as an important partner in the insulin-mediated uptake of glucose by cells, opening the way to potential new drug targets for the prevention and treatment of type 2 diabetes.

3 Apr 2007

What makes a simple biological clock tick?

An interdisciplinary team of researchers at Vanderbilt University has analyzed the simplest known biological clock and figured out what makes it tick.

3 Apr 2007

Unusual protein helps cell bypass damage when making new DNA

Scientists have discovered how an unusual protein helps a cell bypass damage when making new DNA, thereby averting the cell's self-destruction.

3 Apr 2007

Validation of an LED array for use in DNA photocleavage assays

Biology and chemistry researchers from Virginia Tech are creating molecular complexes to bind to and disrupt the DNA of diseased tissues, such as tumors or viruses.

2 Apr 2007

Scientists create small molecules to probe proteins deep inside cell membrane

Proteins, which form much of the molecular machinery required for life, are the targets of most drug molecules.

2 Apr 2007

Fats in our stomach may reduce the protective effects of antioxidants

Scientists at the University of Glasgow found that in the presence of lipid the ability of antioxidants, such as ascorbic acid (the active component of vitamin C), to protect against the generation of potential cancer-forming compounds in the stomach is less than when no lipids are present.

2 Apr 2007

Penn State scientists reveal structure of gateways to gene control

Scientists at Penn State University will reveal in the 29 March 2007 issue of the journal Nature the first complete high-resolution map of important structures that control how genes are packaged and regulated throughout an entire genome.

31 Mar 2007

Researchers identify gene for osteoporosis

Researchers report the identification of a gene that may play a role in susceptibility to osteoporosis, the crippling disease that leads to bone fractures, especially of the hip and spine.

31 Mar 2007

AACR's Sixth Annual Landon Awards recognize Richard Kolodner, Douglas Lowy and John Schiller

Scientists whose discoveries have led to fundamental advances in the science and treatment of cancer are the recipients of two prestigious international prizes offered by the Kirk A. and Dorothy P. Landon Foundation and the American Association for Cancer Research.

22 Mar 2007

Pioneer work on cellular response to DNA Damage wins GlaxoSmithKline award

The Biochemical Society's GlaxoSmithKline Award 'for distinguished research leading to new advances in medical science' goes to Stephen Jackson (University of Cambridge) for his pioneering work on cellular response to DNA damage.

22 Mar 2007

New anti-cancer target in enzyme MAP4K3

Scientists working at the Institute for Cancer Research have found a new anti-cancer target in MAP4K3, an enzyme which is able to 'switch on' the growth-promoter mTOR.

14 Mar 2007

Antifungal drug kills tuberculosis bug

Scientists hoping to find new treatments for one of the world's most deadly infectious diseases say drugs used to treat common fungal infections may provide the answer.

From The University of Manchester 12 Mar 2007

Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling

Administering a small amount of a potent but potentially toxic anticancer agent along with nanoparticles loaded with a second anticancer agent produced a dramatic inhibition of tumor growth in normally intractable cancers. These findings suggest a new approach to treating malignancies such as pancreatic cancer and diffuse gastric cancer.

5 Mar 2007

Ink-jet printing of bone

A modified ink-jet printer can be used to directly print layer upon layer of artificial bone for quick-fix grafts used in reconstructive surgery.

4 Mar 2007

Apolipoprotein C1 protein linked to elevated BMI in people of American Indian and Mexican ancestry

University of Minnesota researchers have discovered a variant of a common blood protein, apolipoprotein C1, in people of American Indian and Mexican ancestry that is linked to elevated body mass index (BMI), obesity and Type 2 diabetes.

22 Feb 2007

Cancer cells 100 times more likely to genetically mutate

When cells become cancerous, they also become 100 times more likely to genetically mutate than regular cells, researchers have found. The findings may explain why cells in a tumor have so many genetic mutations, but could also be bad news for cancer treatments that target a particular gene controlling cancer malignancy.

20 Feb 2007