Biochemistry News and Research

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Nebivolol may restore damaged cardiovascular functions in African Americans

Tadeusz Malinski, Marvin & Ann Dilley White Professor of Chemistry and Biochemistry, found that the drug, currently under review by the U.S. Food and Drug Administration, acts on the level of oxidants lining the cardiovascular system and can restore levels of nitric oxide and reduce oxidative stress.

9 Mar 2006

Scientists create a mosquito resistant to Type 2 dengue fever virus

Researchers have successfully created a genetically engineered mosquito that shows a high level of resistance against the most prevalent type of dengue fever virus, providing a powerful weapon against a disease that infects 50 million people each year.

9 Mar 2006

Details of protein-cleaving complex key to microbe's survival may improve drug design

With the hope of designing more effective treatments for tuberculosis (TB), scientists from the U.S. Department of Energy's Brookhaven National Laboratory and collaborating institutions have published the first detailed reports on the biochemistry and structure of a protein-cleaving complex that is essential to the TB bacterium's survival.

9 Mar 2006

Sex chromosome genes influence aggression

It has been well documented that, across human cultures and in most mammals, males are usually more aggressive and less nurturing than females.

9 Mar 2006

Study looks at how two forms of vitamin E affect the health of animal cells

One of the most powerful antioxidants is truly a double-edged sword, say researchers at Ohio State University who studied how two forms of vitamin E act once they are inside animal cells.

7 Mar 2006

Simple saliva test may offer a new way to probe the consequences of caffeine coupled with stress

Using doses of caffeine equivalent to drinking one to four cups of coffee and an intense arithmetic test as stressors, Klein and her colleagues found a rise in the amount of alpha amylase, an enzyme secreted by the salivary glands, in the healthy young men who participated in the study.

7 Mar 2006

Research shows promise for the advancement of cancer and stem-cell research

The paper explains how proteins, known as epigenetic activators (such as Ash1 from the fruit fly Drosophila), bind to their target DNA and activate genes that determine what function a cell will have in the body.

1 Mar 2006

Hand-held device for detecting illegal and legal drugs

A real-time sensor for detecting cocaine - made with inexpensive, off-the-shelf electronics - has been developed by a team of researchers at the University of California, Santa Barbara.

1 Mar 2006

New mechanism that regulates K-Ras - protein that plays an important role in cancer

Researchers have discovered a protein widely known to cause the out-of-control growth of cells can actually be manipulated to induce those cells to commit suicide, providing a novel target for the development of anti-cancer drugs, according to the results of a new study led by New York University School of Medicine researchers.

21 Feb 2006

New system for analyzing how drugs bind to proteins

Researchers at Florida State University's National High Magnetic Field Laboratory and Scripps Florida have developed and evaluated a robust new system for analyzing how drugs bind to proteins. This groundbreaking work could speed the delivery of potential new drugs and improve existing ones.

19 Feb 2006

Research suggests that a common mechanism may underlie a variety of protein folding diseases

Misfolded and damaged proteins are common to all human neurodegenerative diseases. Clumps of these aggregated proteins destroy neurons within the brain and cause disease.

16 Feb 2006

Scientists discover how to make human collagen in the lab

It is the most important structural protein in the body, reinforcing connective tissue, bones and teeth, and forming long, fibrous cables to strengthen tendons. Collagen forms sheets of tissue that support the skin and every internal organ.

16 Feb 2006

Scientists investigate sugar coating that surrounds bacteria

Scientists at The University of Texas at Austin have developed a quick and simple way to investigate the sugar coating that surrounds bacteria and plays a role in infection and immunity.

16 Feb 2006

Chink in cancer's armor

Much as the famed starship Enterprise would deploy a deflector shield to evade enemy attack, tumor cells are capable of switching on a molecular force field of their own to fend off treatments aimed at killing them. Now University of Florida researchers have found a chink in their armor.

13 Feb 2006

Researchers unmask secrets of a tiny virus that infects bacteria

Using powerful computer tools and cryo-electron microscopes, researchers at Baylor College of Medicine unmasked the secrets of a tiny virus that infects bacteria and, in doing so, opened the door to a better understanding of a variety of viruses that infect people and animals.

13 Feb 2006

Gut protein protects against infection and intestinal breakdown

A protein that binds to bile in the small intestine may hold the key to preventing infection and intestinal breakdown in people with conditions such as obstructive jaundice or irritable bowel syndrome, researchers at UT Southwestern Medical Center have discovered.

12 Feb 2006

Everyday food preservative provides hope for Cystic Fibrosis sufferers

A new study suggests, that something as simple as a common food preservative might help improve the treatment of cystic fibrosis.

30 Jan 2006

Bird flu jab for chickens could halt spread of the virus

U.S. researchers say they have produced a vaccine in less than a month which completely protects chickens from the deadly H5N1 virus.

29 Jan 2006

Proof that proteins can be custom-designed

Ever since the advent of recombinant-DNA technology, scientists have conceived that it will be feasible to create entirely new enzymes for specific needs.

27 Jan 2006

Warning of risk of from vaginal oestrogen

Breast cancer specialists from one of the UK's leading cancer centres cautioned doctors of the risks in prescribing vaginal oestrogen to breast cancer patients being treated with the new aromatase inhibiting drugs, anastrozole, letrozole and exemestane.

26 Jan 2006