Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

Vanderbilt, Celgene collaborate to accelerate development of personalized therapies

Vanderbilt University Medical Center has entered into a strategic research agreement with Celgene Corporation, a biopharmaceutical company based in Summit, New Jersey.

5 Apr 2016

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

Little is known about the molecular basis of aberrant protein glycosylation, a complex enzymatic process that is a hallmark of many human cancers including colorectal cancers (CRC), and how it may contribute to tumor progression. In a new study published in Scientific Reports, an online journal of the Nature Publishing Group, scientists at Case Western Reserve University School of Medicine have successfully characterized the mutational landscapes of glycosylation-associated genes in colon cancer, identifying three glycosyltransferases as significant mutational targets in CRC.

4 Apr 2016

New tool interprets whole-exome tumor sequencing data for better cancer therapies

A University of Colorado Cancer study published today in the Journal of the American Medical Informatics Association describes a new tool that interprets the raw data of whole exome tumor sequencing and then matches the cancer's unique genetics to FDA-approved targeted treatments.

30 Mar 2016

Researchers use novel technology to sequence Y chromosome in malaria spreading mosquitoes

A team of researchers with the Fralin Life Science Institute at Virginia Tech, working with a large international consortium, has sequenced the Y chromosome--the genetic driver of sex-determination and male fertility-- in a family of malaria spreading mosquitoes.

29 Mar 2016

BIDMC investigators identify precise 5-gene classifier for discriminating early pancreatic cancer

Pancreatic cancer, the fourth leading cause of cancer death in the United States, is often diagnosed at a late stage, when curative treatment is no longer possible. A team led by investigators at Beth Israel Deaconess Medical Center has now identified and validated an accurate 5-gene classifier for discriminating early pancreatic cancer from non-malignant tissue.

28 Mar 2016

New project aims to prevent complications from drug usage

If a patient is ill and takes drugs for that illness, these drugs often lead to further illnesses and complications. This affects millions of people throughout the world.

24 Mar 2016

Scientists provide overview of most promising compounds to combat prostate cancer

Scientists from MIPT (Moscow Institute of Physics and Technology), MSU (Moscow State University), and National University of Science and Technology “MISIS” provided an overview of the most promising compounds which can be used as medications for prostate cancer.

23 Mar 2016

Shigella dysenteriae pathogen probably originated in Europe, genetic study reveals

The largest genetic study on the bacterium responsible for epidemic dysentery has revealed that the Shigella dysenteriae pathogen, which remains a real scourge in Africa and Asia, probably originated in Europe.

22 Mar 2016

Novel plasmid-based microRNA inhibitor system effectively prevents microRNA activity in cells

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Brad Amendt, University of Iowa, Iowa City, USA, will present a study titled "New Biotechnology to Inhibit MicroRNA Activity and Novel Applications for Craniofacial and Dental Research."

19 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

Newly developed computer models can simulate stem cell transplant recovery

Scientists at Virginia Commonwealth University have developed computer models that can simulate the recovery of the immune system in patients undergoing stem cell transplants.

18 Mar 2016

UW-Madison neuroscientist discover genetic machinery that causes maturation in young nerve cells

In one of the first studies to 'read' the genetic activity inside individual brain cells, University of Wisconsin-Madison neuroscientist Xinyu Zhao has identified the genetic machinery that causes maturation in a young nerve cell. The cells under study came from the hippocampus, a memory-related structure that is the only place in a mammal's brain where new neurons can form throughout life.

18 Mar 2016

Neo-Bioscore staging system adds HER2 status for precise prognostic stratification of breast cancer subtypes

A new breast cancer staging system developed by researchers at The University of Texas MD Anderson Cancer Center finds that incorporating tumor biology is a critical prognostic indicator for women who undergo neoadjuvant, or pre-surgical, therapy for breast cancer.

18 Mar 2016

Psoriasis patients experience widespread bone loss

Researchers from the Genes, Development and Disease Group, headed by Erwin Wagner at the Spanish National Cancer Research Centre have discovered that psoriasis patients experience a widespread bone loss as a result of the disease.

17 Mar 2016

Scientists synthesize novel selenohydantoins with anticancer and antioxidant activity

A group of scientists from Moscow universities led by Yan Ivanenkov, the head of Laboratory of Medical Chemistry and Bioinformatics in MIPT, has succeeded in synthesizing a set of novel selenohydantoins with anticancer and antioxidant activity.

16 Mar 2016

Researchers discover potentially-pathogenic bacteria in water supply pipes

The human microbiome, a diverse collection of microorganisms living inside us and on our skin, has attracted considerable attention for its role in a broad range of human health issues. Now, researchers are discovering that the built environment also has a microbiome, which includes a community of potentially-pathogenic bacteria living inside water supply pipes.

15 Mar 2016

Russian scientists propose new technique to analyze intestinal metagenomes

A group of Russian scientists, among them staff at the Moscow Institute of Physics and Technology, have proposed a new method for the comparison of metagenome-coupled DNA sequences from all of the organisms in a sample of biological material being investigated.

11 Mar 2016

Scientists map biological networks of genes to gain new insights on disease mechanisms

Innovative software tools allowed the scientists to construct accurate "maps" of gene networks for about 400 different human cell and tissue types, ranging from immune cells to brain tissues, whereas previous studies were limited to just one or few tissues.

11 Mar 2016

MU researchers awarded $4.2 million NSF grant to study corn

Developing drought-tolerant corn varieties that make efficient use of available water is vital to sustain the estimated 9 billion global population by 2050. For the past several decades, University of Missouri researchers have been working to solve this world hunger problem and have made significant strides.

11 Mar 2016

Gar genome helps identify genetic sequences shared by human disease genes and zebrafish

Led by Drs John Postlethwait and Ingo Braasch from the Institute of Neuroscience, University of Oregon, US, in collaboration with the Broad Institute, the study of the Spotted Gar (Lepisosteus oculatus) genome reveals that it is small and manageable. Furthermore, it lacks much shuffling and duplication that occurred in the 'main' fish ancestral line; it conserved its genome.

10 Mar 2016

Bioinformatics News and Research

Further Reading

Vanderbilt, Celgene collaborate to accelerate development of personalized therapies

New CWRU study identifies three glycosyltransferases as major mutational targets in colorectal cancer

New tool interprets whole-exome tumor sequencing data for better cancer therapies

Researchers use novel technology to sequence Y chromosome in malaria spreading mosquitoes

BIDMC investigators identify precise 5-gene classifier for discriminating early pancreatic cancer

New project aims to prevent complications from drug usage

Scientists provide overview of most promising compounds to combat prostate cancer

Shigella dysenteriae pathogen probably originated in Europe, genetic study reveals

Novel plasmid-based microRNA inhibitor system effectively prevents microRNA activity in cells

Manipulation of NAD could lead to potential therapy for acute kidney injury

Newly developed computer models can simulate stem cell transplant recovery

UW-Madison neuroscientist discover genetic machinery that causes maturation in young nerve cells

Neo-Bioscore staging system adds HER2 status for precise prognostic stratification of breast cancer subtypes

Psoriasis patients experience widespread bone loss

Scientists synthesize novel selenohydantoins with anticancer and antioxidant activity

Researchers discover potentially-pathogenic bacteria in water supply pipes

Russian scientists propose new technique to analyze intestinal metagenomes

Scientists map biological networks of genes to gain new insights on disease mechanisms

MU researchers awarded $4.2 million NSF grant to study corn

Gar genome helps identify genetic sequences shared by human disease genes and zebrafish

Lab Diagnostics and Automation - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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