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Aerpio Therapeutics commences AKB-9778 Phase 1b/2a trial in diabetic macular edema

Aerpio Therapeutics, a clinical-stage biopharmaceutical company developing innovative therapies for vascular diseases by targeting the Tie2 pathway, today announced that it has dosed the first patient in a Phase 1b/2a trial of AKB-9778 for the treatment of diabetic macular edema (DME).

20 Sep 2012

Enrollment complete in Gamida Cell’s NiCord Phase I/II trial for hematological malignancies

Gamida Cell, a leader in adult stem cell expansion technologies and products, announced today that it has completed enrollment for a Phase I/II clinical trial of NiCord, the company's second pipeline product.

20 Sep 2012

Obese adults with excess visceral fat, biomarkers of insulin resistance more likely to develop diabetes

Obese adults with excess visceral fat (fat located inside the abdominal cavity, around the body's internal organs) and biomarkers of insulin resistance had an associated increased risk for the development of type 2 diabetes mellitus, while obese individuals with higher amounts of total body fat and subcutaneous fat (underneath the skin) did not have this increased risk, according to a study in the September 19 issue of JAMA, and theme issue on obesity.

20 Sep 2012

APR-246 can restore function of defective p53 and activate apoptosis in cancer cells

The p53 gene plays a key role in the prevention of cancer, by blocking cell growth and triggering programmed cell death or apoptosis. If, however, p53 has mutated and become defective, the cancer cells can acquire the ability to evade apoptosis and become more resistant to therapy.

20 Sep 2012

Study finds links between antibodies for multiple oral bacteria and risk of pancreatic cancer

A new study finds significant associations between antibodies for multiple oral bacteria and the risk of pancreatic cancer, adding support for the emerging idea that the ostensibly distant medical conditions are related.

19 Sep 2012

FDA warns consumers not to use Intestinomicina for treatment of infectious diarrhea

The U.S. Food and Drug Administration is warning consumers not to use Intestinomicina, a drug product manufactured in El Salvador and marketed as a treatment for infectious diarrhea and acute gastrointestinal infections.

19 Sep 2012

Children can largely benefit from 40 minutes of daily, vigorous physical activity

Twenty minutes of daily, vigorous physical activity over just three months can reduce a child's risk of diabetes as well as his total body fat - including dangerous, deep abdominal fat - but 40 minutes works even better, researchers report.

19 Sep 2012

FDA Division of Neurology Products, CoLucid reach agreement for lasmiditan development strategy

CoLucid Pharmaceuticals, Inc., a privately held biopharmaceutical company, has reached agreement with the Food and Drug Administration's Division of Neurology Products concerning the development strategy for lasmiditan at a recently completed End of Phase 2 meeting.

19 Sep 2012

Hereditary blood disorder found in South-East Asia, South-West Pacific could offer clues for malaria vaccine

"A team of international scientists has found that a type of hereditary disorder in some communities in South-East Asia and the South-West Pacific protects its sufferers from malaria, a finding that could drive future vaccine design," SciDev.Net reports.

19 Sep 2012

Scientists discover bone abnormalities in rats undergoing chronic lack of sleep

Scientists at the Medical College of Wisconsin, in a team led by Carol Everson, Ph.D., professor of neurology, cell biology, neurobiology and anatomy, have discovered abnormalities in bone and bone marrow in rats undergoing chronic lack of sleep. They discovered abnormalities in serum markers of bone metabolism in sleep-deprived rats, which led them to conduct direct measurements of bone parameters; this time in rats experiencing recurrent sleep restriction during a large portion of their young adulthood.

19 Sep 2012

Devon Medical Products receives PDAC approval for extriCARE 2400 system

Devon Medical Products, a global medical device manufacturer and distributor, today announced it has received approval from the Pricing, Data Analysis, and Coding (PDAC) contractor for its extriCARE 2400 Negative Pressure Wound Therapy (NPWT) pump and associated bandages and disposable canister.

19 Sep 2012

Diet, lack of AgRP-neurons can lead to obesity and diabetes

The absence of a specific type of neuron in the brain can lead to obesity and diabetes in mice report researchers in The EMBO Journal. The outcome, however, depends on the type of diet that the animals are fed.

19 Sep 2012

FDA clears Aptus’ HeliFX Aortic Securement System

Aptus Endosystems, Inc., a medical device company developing advanced technology for endovascular aneurysm repair (EVAR), announced today that it received 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its thoracic-length HeliFX Aortic Securement System.

From Medtronic 19 Sep 2012

Viral cause excluded for chronic fatigue syndrome

New research suggests that chronic fatigue syndrome does not occur as a result of infection with xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus.

19 Sep 2012

Age at diabetes onset linked to macular edema onset

Older age at onset of Type 1 diabetes significantly increases the risk for developing clinically significant macular edema, show study findings.

19 Sep 2012

i-gel airway device provides reliable anesthesia ventilation

The i-gel supraglottic airway device provides reliable ventilation in patients under anesthesia, results of a prospective multicentre observational study show.

19 Sep 2012

Illumina launches new RNA sequencing kits

Illumina today introduced TruSeq Stranded mRNA and Total RNA Sample Preparation Kits for RNA sequencing. The new reagent kits enable researchers to quickly and easily conduct gene expression studies that provide a complete view of the transcriptome, even from low-quality RNA samples, such as formalin-fixed, paraffin-embedded (FFPE) samples.

From Illumina, Inc. 19 Sep 2012

Blood News and Research

Aerpio Therapeutics commences AKB-9778 Phase 1b/2a trial in diabetic macular edema

Enrollment complete in Gamida Cell’s NiCord Phase I/II trial for hematological malignancies

Obese adults with excess visceral fat, biomarkers of insulin resistance more likely to develop diabetes

APR-246 can restore function of defective p53 and activate apoptosis in cancer cells

Study finds links between antibodies for multiple oral bacteria and risk of pancreatic cancer

FDA warns consumers not to use Intestinomicina for treatment of infectious diarrhea

Children can largely benefit from 40 minutes of daily, vigorous physical activity

FDA Division of Neurology Products, CoLucid reach agreement for lasmiditan development strategy

Hereditary blood disorder found in South-East Asia, South-West Pacific could offer clues for malaria vaccine

Scientists discover bone abnormalities in rats undergoing chronic lack of sleep

Devon Medical Products receives PDAC approval for extriCARE 2400 system

Diet, lack of AgRP-neurons can lead to obesity and diabetes

FDA clears Aptus’ HeliFX Aortic Securement System

Viral cause excluded for chronic fatigue syndrome

Age at diabetes onset linked to macular edema onset

i-gel airway device provides reliable anesthesia ventilation

Illumina launches new RNA sequencing kits

Friendly bacteria: do we really need to eat probiotic yogurts?

Tranexamic acid: an interview with Prof Ian Roberts

Exercise may help prevent infection for paraplegic individuals

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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