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Link between small birth size and changes to the CV system that predispose to disease in later life

Researchers have found the first evidence that smaller size at birth is associated with specific alterations in the functioning of the heart and circulation in children and that these changes differ between boys and girls.

22 Jul 2008

New hope for infertile men - venous embolization

A minimally invasive treatment for a common cause of male infertility can significantly improve a couple's chances for pregnancy, according to a new study published in the August issue of Radiology. The study, conducted at the University of Bonn in Germany, also found that the level of sperm motility prior to treatment is a key predictor of success.

22 Jul 2008

Functional human blood vessels grown in mice using cells from adult human donors

For the first time, researchers have successfully grown functional human blood vessels in mice using cells from adult human donors - an important step in developing clinical strategies to grow tissue, researchers report in Circulation Research: Journal of the American Heart Association.

19 Jul 2008

Could arthritis wonder drugs provide clues for all disease?

Drugs that have helped treat millions of rheumatoid arthritis sufferers may hold the key to many more medical conditions, including atherosclerosis - a leading cause of heart disease - says the researcher who jointly invented and developed them.

From The University of Manchester 17 Jul 2008

New ultrasound imaging system spots early evidence of peripheral arterial disease

Researchers at Oregon Health & Science University have devised an ultrasound imaging technique that picks up subtle early evidence of peripheral arterial disease (PAD) that current conventional tests miss.

17 Jul 2008

New therapies revealed for diabetes-induced microvascular disease

New findings from Bristol scientists could lead to future treatments to prevent lower limb amputations in diabetes - which currently affect 100 people a week in the UK (source Diabetes UK). The research from the University of Bristol is published online in Circulation Research and was funded by the British Heart Foundation (BHF) and the European Vascular Genomic Network of Excellence (EVGN).

17 Jul 2008

New understanding of fetal hemoglobin regulation in patients with sickle cell disease

Although sickle cell disease is a single-gene disorder, its symptoms are highly variable. In a study published online July 14 by the Proceedings of the National Academy of Sciences, scientists at Children's Hospital Boston and the Dana Farber Cancer Institute (DFCI), in collaboration with the Broad Institute of MIT and Harvard, report five gene variants that could potentially be helpful in predicting sickle cell disease severity, perhaps even leading to better treatment approaches in the future.

15 Jul 2008

Improving understanding of cell behaviour in breast cancer

The invasion and spread of cancer cells to other parts of the body, known as metastasis, is a principal cause of death in patients diagnosed with breast cancer. Although patients with early stage, small, breast tumours have an excellent short term prognosis, more than 15 to 20 per cent of them will eventually develop distant metastases, and die from the disease. Vascular invasion - through lymphatic and blood vessels - is the major route for cancer spreading to regional lymph nodes and to the rest of the body.

15 Jul 2008

FA imaging, invented at U-M, measures metabolic stress in retina - serves as early warning of diabetes

A new vision screening device, already shown to give an early warning of eye disease, could give doctors and patients a head start on treating diabetes and its vision complications, a new study shows.

14 Jul 2008

Novel approach shows potential to become an emergency treatment for heart attack patients

Researchers at The Children's Hospital of Philadelphia have manipulated cell activity that occurs during the interruption of blood flow to strongly protect heart tissue in animal studies. The finding has the potential to become an emergency treatment for heart attack patients, particularly since already existing drugs might be pressed into service to produce the protective effects.

10 Jul 2008

Scientists reveal potential new target for anti-malarial drugs

Scientists funded by the Wellcome Trust have identified a key mechanism that enables malaria-infected red blood cells to stick to the walls of blood vessels and avoid being destroyed by the body's immune system. The research, published today in the journal Cell, highlights an important potential new target for anti-malarial drugs.

10 Jul 2008

Combining medical knowledge to save lives

Cardiovascular disease (CVD) is the biggest killer among chronic diseases, claiming 17 million lives globally every year. Yet doctors can only attribute 50% of cardiovascular diseases to known risk factors.

9 Jul 2008

Nanomaterials key to new strategies for blocking metastasis

A new treatment strategy using targeted nanoparticles to block metastasis with anti-cancer drugs leads to good results using significantly lower doses of toxic chemotherapy, with less collateral damage to surrounding tissue, according to a collaborative team of researchers at the Center of Nanotechnology for Treatment, Understanding, and Monitoring of Cancer at the University of California, San Diego. In designing this system, the investigators, led by David Cheresh, Ph.D., have identified what may become a generic method for using nanotechnology to target metastasis.

9 Jul 2008

Holey nanoparticles create new tumor imaging and therapeutic agent

Using a polymer that has both water-soluble and water-insoluble regions, a team of investigators from the Siteman Center of Cancer Nanotechnology Excellence has created a nanoparticle shaped like a bialy, a close relative of the bagel. Combining this nanoparticle with manganese, a metal that boosts magnetic resonance imaging signals, and an antibody that targets blood vessels, the investigators then created a new type of imaging agent that also has the potential to deliver drugs to tumors.

9 Jul 2008

Smart nanoparticle bomb precisely targets a tumour's blood vessels

A team of researchers in the U.S. have developed a nanoparticle with the ability to precisely deliver cancer-fighting drugs.

9 Jul 2008

New understanding of how malaria parasite survives in and totally changes red blood cells

A new study-done on a scale an order of magnitude greater than anything previously attempted in the field of malaria-has uncovered an arsenal of proteins produced by the malaria parasite that allows it to hijack and remodel human red blood cells, leaving the oxygen-carrying cells stiff and sticky.

8 Jul 2008

Farm-raised tilapia fish contains potentially dangerous fatty acid combination

"Farm-raised tilapia, one of the most highly consumed fish in America, has very low levels of beneficial omega-3 fatty acids and, perhaps worse, very high levels of omega-6 fatty acids, according to new research from Wake Forest University School of Medicine.

8 Jul 2008