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Receptor for prostaglandin-E2 plays key role in atherosclerosis development

Atherosclerosis - a disease that includes the buildup of fatty, cholesterol-laden lumps of cells inside the artery wall - is the underlying cause of heart attacks and strokes.

15 Dec 2008

Three-quarters of youths with type 1 diabetes have vitamin D deficiency

Three-quarters of youths with type 1 diabetes were found to have insufficient levels of vitamin D, according to a study by researchers at the Joslin Diabetes Center - findings that suggest children with the disease may need vitamin D supplementation to prevent bone fragility later in life.

15 Dec 2008

Mouse model shows blood stem cells in action

Over a period of five years, scientists at the Johannes Gutenberg University Mainz have managed to create a genetically modified mouse in which the activity of the blood stem cells can be tracked.

15 Dec 2008

Planned safety analysis of a breast cancer prevention study reveals encouraging news for Exemestane

An interim analysis of a breast cancer prevention study using exemestane (Aromasin) finds an "acceptable" level of bone loss.

14 Dec 2008

Zometa (zoledronic acid) shown to enhance chemotherapy in reducing breast tumor size

New data released demonstrates that the addition of Zometa (zoledronic acid) injection to standard chemotherapy before breast cancer surgery reduces the size of breast tumors more effectively than chemotherapy alone in women with early-stage disease.

14 Dec 2008

Gene therapy used to treat periodontal disease

Scientists at the University of Michigan have shown that gene therapy can be used to successfully stop the development of periodontal disease, the leading cause of tooth loss in adults.

12 Dec 2008

Studies on imaging and tracking transplanted cells

Successfully monitoring the distribution and fate of transplanted stem cells through imaging and subsequent tracking would aid clinicians in their ability to evaluate the efficacy of transplanted cells.

10 Dec 2008

$Proteolix announces positive data for carfilzomib in patients with relapsed and refractory multiple myeloma$

Proteolix announces positive data for carfilzomib in patients with relapsed and refractory multiple myeloma

Proteolix, Inc. today announced positive clinical data demonstrating that the company's lead product, carfilzomib, has single-agent activity and promotes durable responses in patients with relapsed and refractory multiple myeloma.

10 Dec 2008

Children who are overweight or obese have increased risk of arm and leg injuries following motor vehicle crash

Children who are overweight or obese are over two and a half times more likely to suffer injuries to their upper and lower extremities following a motor vehicle crash compared with normal weight children, according to a new report from the Johns Hopkins Bloomberg School of Public Health's Center for Injury Research and Policy.

10 Dec 2008

Insufficient vitamin D causes weight gain and stunts growth in girls

Even in sun-drenched California, where scientists from the McGill University Health Centre (MUHC) and the University of Southern California conducted their study, vitamin D deficiency was found to cause higher body mass and shorter stature in girls at the peak of their growing spurt.

10 Dec 2008

High phosphorus levels in blood linked to coronary calcification in chronic kidney disease

For patients with moderate chronic kidney disease (CKD), higher levels of phosphorus in the blood are associated with increased calcification of the major arteries and heart valves - which may contribute to the increased risk of cardiovascular disease in patients with CKD, reports a study in the Journal of the American Society of Nephrology (JASN).

10 Dec 2008

Scientists create first functional stem-cell niche model

Like it or not, your living room probably says a lot about you. Given a few uninterrupted moments to poke around, a stranger could probably get a pretty good idea of your likes and dislikes, and maybe even your future plans.

10 Dec 2008

3D imaging technology improves spinal surgery outcome

Using a three-dimensional (3D) image-guided system to help place screws in the spines of patients results in safe and accurate surgery with a decrease in the number of misplaced screws, and subsequent injuries, seen in more traditional operations, say neurosurgeons at Mayo Clinic in Florida.

10 Dec 2008

$Thiazolidinediones doubles risk of fractures in women$

Thiazolidinediones doubles risk of fractures in women

New findings out of Wake Forest University School of Medicine and the University of East Anglia show that long-term use of a popular class of oral diabetic drugs doubles the risk of fractures in women with type 2 diabetes.

10 Dec 2008

VIDAZA (azacitidine) study reports survival benefit in higher-risk MDS extends to AML patients

Celgene International Sàrl (NASDAQ: CELG) today announced results from a subset analysis of the international phase III trial (AZA-001) demonstrating that the overall survival benefit observed in higher-risk MDS patients extended to patients with acute myeloid leukemia (AML).

10 Dec 2008

Experimental drug successfully blocks mutation in bone marrow cancers

Oregon Health & Science University Knight Cancer Institute researchers have found that an experimental drug successfully blocks an enzyme that causes some bone marrow cancers.

10 Dec 2008

Intense chemo wards off recurrence in half of mantle cell lymphoma patients after seven years

More than half of younger mantle cell lymphoma patients who received an intensive regimen of chemotherapy as frontline treatment remain in remission seven years later, researchers at The University of Texas M. D. Anderson Cancer Center report today at the 50th annual meeting of the American Society of Hematology.

10 Dec 2008

Bone News and Research

Receptor for prostaglandin-E2 plays key role in atherosclerosis development

Three-quarters of youths with type 1 diabetes have vitamin D deficiency

Mouse model shows blood stem cells in action

Planned safety analysis of a breast cancer prevention study reveals encouraging news for Exemestane

Zometa (zoledronic acid) shown to enhance chemotherapy in reducing breast tumor size

Gene therapy used to treat periodontal disease

Studies on imaging and tracking transplanted cells

Proteolix announces positive data for carfilzomib in patients with relapsed and refractory multiple myeloma

Children who are overweight or obese have increased risk of arm and leg injuries following motor vehicle crash

Insufficient vitamin D causes weight gain and stunts growth in girls

High phosphorus levels in blood linked to coronary calcification in chronic kidney disease

Scientists create first functional stem-cell niche model

3D imaging technology improves spinal surgery outcome

Thiazolidinediones doubles risk of fractures in women

VIDAZA (azacitidine) study reports survival benefit in higher-risk MDS extends to AML patients

Experimental drug successfully blocks mutation in bone marrow cancers

Intense chemo wards off recurrence in half of mantle cell lymphoma patients after seven years

New titanium dental implant

Drug combo improves or stabilizes disease for relapsed multiple myeloma patients

Dacogen data presented on trial in seniors with acute myeloid leukemia

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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