Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Aastrom Biosciences responds to article regarding contaminated stem cell lines

Aastrom Biosciences responded today to the publication in the Sunday online edition of Nature Medicine of findings by California researchers that indicate that certain lines of human embryonic stem cells have been contaminated through the use of mice feeder cells.

25 Jan 2005

New blood tests to soon replace painful bone marrow biopsies for leukemia and lymphoma patients

Quest Diagnostics Incorporated announced today that The University of Texas M. D. Anderson Cancer Center in Houston has granted the company exclusive use of five proprietary blood testing methods, which, once available in the form of laboratory diagnostic tests, may eliminate the need for painful and expensive bone marrow and other tissue extractions.

24 Jan 2005

Recent study correlates human cord blood cells with reduced animal heart attack damage

Researchers from the University of South Florida (USF) and James A. Haley Veterans Hospital have reported in the journal "Cell Transplantation" that stem cells from umbilical cord blood effectively treated heart attacks in an animal study.

12 Jan 2005

Scientists examine the role of small sputum macrophages in the widespread disease chronic obstructive bronchitis

COPD (chronic obstructive pulmonary disease) is one of the most common fatal diseases worldwide. In Germany alone, there are about 3-5 million patients affected. COPD includes both chronic obstructive bronchitis and emphysema. Both represent irreversible changes of the central and lower respiratory tract which are accompanied by coughing, mucus production and difficulty in breathing.

10 Jan 2005

Potential new therapies for cancer and bleeding disorders

Lexicon Genetics announced today that it has advanced two of its drug discovery programs into preclinical development in preparation for investigational new drug (IND) applications.

10 Jan 2005

Velcade (bortezomib) phase III clinical trial initiated in patients with newly diagnosed multiple myeloma

Millennium Pharmaceuticals today announced, in collaboration with Johnson & Johnson Pharmaceutical Research & Development, LLC, the initiation of VISTA (Velcadeas Initial Standard Therapy in multiple myeloma: Assessment with melphalan and prednisone), a multicenter, international phase III clinical trial of Velcadein combination with melphalan and prednisone versus melphalan and prednisone in patients with newly diagnosed multiple myeloma (MM) who are not transplant candidates.

10 Jan 2005

Potential cure for lymphoma in HIV patients

Stem cell transplants have become the standard of care for patients with relapsed lymphoma, but not for patients who suffer from both this disease and HIV.

7 Jan 2005

Stem cells from umbilical cord blood effectively treated heart attacks

When injected into rats' hearts soon after a heart attack, stem cells taken from human umbilical cord blood (HUCB) greatly reduced the size of heart damage and restored pumping function to near normal. This improvement occurred without the need for drugs to prevent the rats' immune system from rejecting the human cells.

5 Jan 2005

Chemotherapy lowers levels of antioxidants and micronutrients

Children undergoing chemotherapy for acute lymphoblastic leukemia (ALL) have significant changes in their antioxidant and micronutrient status which are related to their treatment outcomes, according to the results of a novel prospective study.

28 Dec 2004

Study finds new method can improve chemo survival

Seeking to find a way to lessen patients’ vulnerability to deadly infections following chemotherapy, researchers at the Stanford University School of Medicine have figured out a way to boost the immune function in animals following such treatments.

21 Dec 2004

Gene therapy effective in helping children with severe combined immunodeficiency (SCID)

A UK study in this week’s issue of THE LANCET provides further evidence that gene therapy can be effective in creating a functional immune system for infants with severe combined immunodeficiency (SCID).

20 Dec 2004

Landmark revascularization procedure

The People's Hospital of Beijing University performed a combined revascularization procedure utilizing beating heart bypass surgery, along with transmyocardial revascularization and stem cell implantation.

13 Dec 2004

Thiazolidinedione (TZD) class of anti-diabetic drugs may be a potential targeted therapy for myeloma patients

In laboratory tests on multiple myeloma cells, University of Rochester researchers found that this type of cancer expresses a protein that makes it an easy target for an existing class of diabetes drugs. After more investigation, they hope the discovery will lead to a new, targeted therapy for myeloma patients.

8 Dec 2004

Transplanted bone marrow cells reduce liver fibrosis in mice

Transplanted bone marrow cells can reduce carbon tetrachloride-induced liver fibrosis in mice and significantly improve their survival rates, according to a new study

8 Dec 2004

Revlimid clinical data in newly diagnosed multiple myeloma presented

Celgene Corporation announced today that data evaluating clinical results on Revlimid (lenalidomide) as a new therapeutic approach for patients with newly diagnosed multiple myeloma (MM) was presented at the American Society of Hematology 46th Annual Meeting in San Diego.

7 Dec 2004

Combination of thalidomide and dexamethasone may be a promising treatment for multiple myeloma

The combination of two pills -- thalidomide and dexamethasone -- may be an effective alternative to the intravenous chemotherapy commonly prescribed to patients with multiple myeloma, according to a large collaborative study conducted by the Eastern Cooperative Oncology Group and led by a Mayo Clinic investigator.

7 Dec 2004

Measuring bone marrow fat can better predict weakening of bones

BMD measurement with DEXA is presently the most commonly used parameter for determining bone weakening. Researchers have long questioned whether there may be other measurable bone components that influence mechanical stability of bone.

7 Dec 2004

Thalidomide shows promise in fighting myeloma

Thalidomide, a drug often used to treat symptoms of leprosy and in testing to fight HIV, is now demonstrating activity in fighting a common cancer that occurs in bone marrow, myeloma.

6 Dec 2004

New advances in sickle cell disease

Excruciating pain episodes, recurrent pneumonias, strokes, severe infections, chronic hemolytic anemia, and secondary pulmonary hypertension are common complications of sickle cell disease, a life-threatening inherited defect in blood that causes normally disc-shaped red blood cells to take on a sickle shape.

6 Dec 2004

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

Bone Marrow News and Research

Further Reading

Aastrom Biosciences responds to article regarding contaminated stem cell lines

New blood tests to soon replace painful bone marrow biopsies for leukemia and lymphoma patients

Recent study correlates human cord blood cells with reduced animal heart attack damage

Scientists examine the role of small sputum macrophages in the widespread disease chronic obstructive bronchitis

Potential new therapies for cancer and bleeding disorders

Velcade (bortezomib) phase III clinical trial initiated in patients with newly diagnosed multiple myeloma

Potential cure for lymphoma in HIV patients

Stem cells from umbilical cord blood effectively treated heart attacks

Chemotherapy lowers levels of antioxidants and micronutrients

Study finds new method can improve chemo survival

Gene therapy effective in helping children with severe combined immunodeficiency (SCID)

Landmark revascularization procedure

Thiazolidinedione (TZD) class of anti-diabetic drugs may be a potential targeted therapy for myeloma patients

Transplanted bone marrow cells reduce liver fibrosis in mice

Revlimid clinical data in newly diagnosed multiple myeloma presented

Combination of thalidomide and dexamethasone may be a promising treatment for multiple myeloma

Measuring bone marrow fat can better predict weakening of bones

Thalidomide shows promise in fighting myeloma

New advances in sickle cell disease

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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