Brain Metastases News and Research

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Laboratory and mouse studies show targeted drug blocks the growth of breast cancer cells that spread to the brain

Using laboratory and mouse models of human breast cancer, researchers have found that a small molecule capable of targeting specific proteins on the surface of breast cancer cells can inhibit the growth of breast cancer cells that migrate to the brain.

29 Jul 2008

Breast cancer subtypes linked to survival from secondary brain tumors

Screening breast cancers for three receptors could help doctors predict the likely survival of patients with brain metastases.

28 Feb 2008

Combo therapy reduces size of brain tumours

According to a major drug manufacturer, a combination drug treatment appears to be effective in fighting breast cancer that has spread to the brain.

19 Dec 2007

Survival shortened when estrogen or progesterone receptor negative breast cancer spreads to the brain

Two studies from Mayo Clinic's site in Jacksonville, Fla., of women whose breast cancer spread to their brain, have found that women whose tumors do not have estrogen or progesterone receptors have the worst overall outcomes.

17 Dec 2007

Targeted therapy and chemotherapy shrinks breast cancer metastases in brain

A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber Cancer Institute investigators at the San Antonio Breast Cancer Symposium.

17 Dec 2007

Wilmot Cancer Center adds gastrointestinal, brain cancer experts

Three specialists in gastrointestinal and brain cancers recently joined the James P. Wilmot Cancer Center at the University of Rochester Medical Center to meet the growing need in the Rochester and Upstate New York region.

1 Oct 2007

Prophylactic cranial irradiation in small cell lung cancer significantly increases survival

Prophylactic cranial irradiation after chemotherapy significantly reduces the risk of brain metastasis and doubles one-year survival in small-cell lung cancer (SCLC), according to the results of the multicenter phase III randomized EORTC trial 08993-22993, published in the New England Journal of Medicine.

17 Aug 2007

Drug lapatinib shows activity against brain metastases

The drug lapatinib shrank tumors and slowed progression of brain metastases in some patients with advanced breast cancer, according to results of a clinical trial presented by Dana-Farber Cancer Institute scientists at the annual meeting of the American Society of Clinical Oncology.

5 Jun 2007

Pharmacyclics announces NDA for Xcytrin injection

Pharmacyclics, Inc. has announced that the U.S. Food and Drug Administration (FDA) has filed the company's New Drug Application (NDA) for Xcytrin (motexafin gadolinium) Injection.

24 Apr 2007

Pharmacyclics undergoes 'file over protest' for Xcytrin NDA

Pharmacyclics, Inc. has announced its request to the U.S. Food and Drug Administration (FDA) that its New Drug Application (NDA) for Xcytrin (motexafin gadolinium) Injection be filed over protest.

5 Apr 2007

Treatment options for brain metastases

Adding whole-brain radiation therapy to highly-focused radiation therapy does not improve survival for patients with cancer and brain metastases, but it may reduce the likelihood of the recurrence of brain metastases.

7 Jun 2006

Treating four or more brain tumors in a single radiosurgery session resulted in improved survival

...compared to whole brain radiation therapy alone, according to a study the University of Pittsburgh School of Medicine presented today at the 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Denver.

18 Oct 2005

Bevacizumab plus chemo extends survival beyond one year for large group of advanced lung cancer patients

Patients with a particular type of advanced lung cancer may have a new option based on data presented at the 2005 annual meeting of the American Society of Clinical Oncology showing that combining a drug that cuts off the cancer's blood supply with standard chemotherapy can shrink tumors and extend life.

15 May 2005

Isotopes for society

The nucleus of an atom contains protons and neutrons. However, some atoms of the same chemical element can have varying numbers of neutrons, giving so-called isotopes of that element.

27 Apr 2005

Prognostic factors influencing survival in patients with brain metastases identified

Allos Therapeutics has announced the presentation of new findings from its Phase 3 clinical trial of the investigational radiation sensitizer Efaproxyn (efaproxiral) in patients with brain metastases.

4 Oct 2004

Combination of two types of radiation therapy is better for treating brain cancer

Adding stereotactic radiosurgery – which entails delivering radiation to specific points in the brain while sparing normal tissue – after whole brain radiation therapy helps certain patients with cancer that has spread to the brain live longer, says a new study by researchers at Thomas Jefferson University Hospital in Philadelphia.

25 May 2004

Combination radiation treatment for brain cancer leads to better life

People with cancer that has spread to the brain – about 40 percent of all cancer cases – live longer and enjoy a better quality of life if they are treated with a combination of radiation techniques, according to research conducted, in part, at the James P. Wilmot Cancer Center at the University of Rochester Medical Center.

21 May 2004