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Study links pancreatic cancer survival outcomes with arrangement of immune cells in tumors

Researchers from Johns Hopkins Medicine have discovered that the organization of different types of immune cells within pancreatic tumors is associated with how well patients with pancreatic cancer respond to treatment and how long they survive.

6 Oct 2022

Did telehealth appointments improve HIV care retention during the COVID-19 pandemic?

In a new study, researchers assessed how measures of retention in human immunodeficiency virus (HIV) care have changed due to the COVID-19 pandemic.

6 Oct 2022

Epigenetics drug used to treat blood cancers, rare sarcomas can halt bladder cancer growth

An epigenetics drug currently being used for the treatment of blood cancers and rare sarcomas can stop the growth of bladder cancer by activating the immune system, reports a new Northwestern Medicine study done in mice.

5 Oct 2022

Novel protein vaccine NVX-CoV2373 triggered functional T cell responses to SARS-CoV-2

Researchers determined the T cell response to the NVX-CoV2373, an adjuvanted recombinant full-length SARS-CoV-2 spike (S) trimer protein vaccine.

5 Oct 2022

Omicron reduces host antibody response by lower B-cell antigenicity

A new study explores the functional relevance of some Omicron mutations in terms of their ability to escape neutralizing antibody responses.

4 Oct 2022

How COVID-19 affects the female reproductive system

A new review in the Biology of Reproduction journal analyzed the relationship between the immune system and the female reproductive system while focusing on the effects of COVID-19-associated immune responses on the reproductive system. The study searched PubMed to identify peer-reviewed literature in English up to May 2022 and finally included 83 studies.

3 Oct 2022

A case for updating COVID vaccines with beta variant spike sequences

A recent Nature Communications study has discussed preclinical and clinical data on COVID-19 vaccine antigens that could be utilized to develop effective booster vaccines.

3 Oct 2022

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Researchers evaluated the efficacy, immunogenicity, and safety of a novel SARS-CoV-2 linear deoxyribonucleic acid vaccine in ferret models delivered using intramuscular injection and electroporation.

3 Oct 2022

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

A new study focused on the immune system's Th17 cells suggests that the shape and function of their mitochondria (the powerhouse of cells) is important in autoimmune and inflammatory disorders, such as multiple sclerosis.

28 Sep 2022

Dietary fiber guar gum limits inflammation and delays the onset of MS symptoms in mice

Diets high in guar gum, a common food additive and dietary fiber, limited inflammation and delayed the onset of multiple sclerosis (MS) symptoms in mice, according to new research by members of the University of British Columbia Microbiology and Immunology department.

27 Sep 2022

Transplantation tolerance associated with conventional T cells’ susceptibility to Treg suppression

Patients who receive organ transplants must take powerful medications to prevent the immune system from rejecting the organ.

27 Sep 2022

Dietary sugar may disrupt gut microbiota and induce metabolic complications

A new study demonstrates that dietary sugar increases the risk of metabolic syndrome by disrupting gut microbiota and suppressing protective T helper 17 (Th17) cells.

22 Sep 2022

Why fatigue from long COVID goes beyond simply feeling tired

In a recent study posted to the medRxiv* preprint server, researchers in the Netherlands examined the role of inflammatory genes, cytotoxic T-lymphocytes (CD8+ T cells), and pro-inflammatory cytokines in long-lasting severe fatigue experienced by a large number of coronavirus disease 2019 (COVID-19) patients.

21 Sep 2022

Monkeypox virus infection in an immunocompromised patient

Researchers assessed the manifestations of the monkeypox infection in an immunocompromised patient.

19 Sep 2022

Bivalent recombinant vaccine protects against SARS-CoV-2 and influenza in animal models

In a new study, researchers developed a recombinant bivalent vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses.

15 Sep 2022

Mechanism of action of different COVID-19 vaccines

In a recent study posted to the bioRxiv* preprint server, researchers at the University of Tuebingen and Imperial College London assessed humoral and cellular immune responses elicited by the recombinant adenoviral vector (rAdVV)- and messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccines.

14 Sep 2022

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

A new study describes the changes in immune T cell profile over time following monkeypox infection.

14 Sep 2022

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

In a recent study published in the journal eBioMedicine, researchers in Denmark and Sweden administered a cationic liposome-adjuvanted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit vaccine as a subcutaneous (s.c.) prime-intranasal (i.n.) boost strategy to elicit mucosal immune responses among SARS-CoV-2-infected Syrian hamsters.

14 Sep 2022

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

Scientists define the immune responses against COVID-19 in HD patients who received three mRNA COVID-19 vaccine doses.

13 Sep 2022

The impact of the infant gut microbiome on vaccine efficacy

A new study reports the effect of the infant gut microbiome on vaccine efficacy.

13 Sep 2022

CD4 News and Research

Study links pancreatic cancer survival outcomes with arrangement of immune cells in tumors

Did telehealth appointments improve HIV care retention during the COVID-19 pandemic?

Epigenetics drug used to treat blood cancers, rare sarcomas can halt bladder cancer growth

Novel protein vaccine NVX-CoV2373 triggered functional T cell responses to SARS-CoV-2

Omicron reduces host antibody response by lower B-cell antigenicity

How COVID-19 affects the female reproductive system

A case for updating COVID vaccines with beta variant spike sequences

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

Dietary fiber guar gum limits inflammation and delays the onset of MS symptoms in mice

Transplantation tolerance associated with conventional T cells’ susceptibility to Treg suppression

Dietary sugar may disrupt gut microbiota and induce metabolic complications

Why fatigue from long COVID goes beyond simply feeling tired

Monkeypox virus infection in an immunocompromised patient

Bivalent recombinant vaccine protects against SARS-CoV-2 and influenza in animal models

Mechanism of action of different COVID-19 vaccines

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

Altered T-cell response in hemodialysis patients following third COVID-19 vaccine dose

The impact of the infant gut microbiome on vaccine efficacy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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