Cadherin News and Research

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Study underlines critical role of Fragile X mental retardation protein in brain development

Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability (ID), as well as the most frequent monogenic cause of autism spectrum disorders (ASD). FXS is caused by the absence or incorrect production of the protein FMRP (Fragile X Mental Retardation Protein).

17 Nov 2014

TNF-α key player in RCC progression

Tumour necrosis factor - α appears to play a key role in the promotion of invasion and metastasis in clear cell renal cell carcinomas, Japanese study findings indicate.

30 Oct 2014

Ludwig researchers discover key mechanism that control plasticity of epithelial cells

Ludwig Oxford researchers have discovered a key mechanism that governs how cells of the epithelia, the soft lining of inner body cavities, shift between a rigid, highly structured and immobile state and a flexible and motile form.

27 Oct 2014

Researchers discover new function of body's most important tumor-suppressing protein

Researchers at Cold Spring Harbor Laboratory (CSHL) have discovered a new function of the body's most important tumor-suppressing protein. Called p53, this protein has been called "the guardian of the genome."

30 Jul 2014

UCSB study shows that key protein in epithelial cells plays important roles in how cells sense direction

What do sled dogs and cell clusters have in common? According to research by UC Santa Barbara's Denise Montell, they both travel in groups and need a leader to make sure they all follow in the same direction.

23 May 2014

Fourteen businesses receive innovative funding to improve kidney care

NEW ideas and technologies that could prevent kidney disease, allow earlier diagnosis and give patients greater independence are to be developed thanks to an innovative funding competition developed.

From Randox Laboratories Ltd. 15 May 2014

Study provides better understanding of intestinal pathologies associated with inherited, infectious diseases

The "brush border" - a densely packed array of finger-like projections called microvilli - covers the surfaces of the cells that line our intestines.

17 Apr 2014

Researchers discover tumor suppressor gene folliculin essential to normal lung function in BHD patients

11 Apr 2014

Researchers discover mechanism that control normal lung function in patients with BHD syndrome

Researchers at Penn Medicine have discovered that the tumor suppressor gene folliculin (FLCN) is essential to normal lung function in patients with the rare disease Birt-Hogg-Dube (BHD) syndrome, a genetic disorder that affects the lungs, skin and kidneys. Folliculin's absence or mutated state has a cascading effect that leads to deteriorated lung integrity and an impairment of lung function, as reported in their findings in the current issue of Cell Reports.

11 Apr 2014

New research links spread of colon cancer to PLAC8 protein

New research at Washington University School of Medicine in St. Louis and Vanderbilt University Medical Center in Nashville has implicated a poorly understood protein called PLAC8 in the spread of colon cancer.

2 Apr 2014

H4 receptor activation plays part in NSCLC progression

Histamine H4 receptor activation decreases epithelial-to-mesenchymal transmission in non-small-cell lung cancer, Chinese research shows.

27 Feb 2014

Selective FAK inhibition within endothelial cells prevents spontaneous tumor metastasis

A team of scientists, led by principal investigator David D. Schlaepfer, PhD, a professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine, has found that a protein involved in promoting tumor growth and survival is also activated in surrounding blood vessels, enabling cancer cells to spread into the bloodstream.

24 Jan 2014

Shared genetic risk for bipolar disorder and BMI

Researchers have found a positive association in the heritability of bipolar disorder and body mass index, supporting the theory that there is some interaction in the genetic mechanisms underlying these two traits.

19 Dec 2013

Cells sticking molecule over-produced in rheumatoid arthritis and cancers

A molecule that helps cells stick together is significantly over-produced in two very different diseases - rheumatoid arthritis and a variety of cancers, including breast and brain tumors, concludes a new study. The scientists who made the discovery also found candidate drugs to inhibit the molecule, cadherin-11, one of which is already in a clinical trial.

14 Nov 2013

Study reveals role of cadherin receptor BT-R3 in killing action of Cry4B mosquito toxin

Researchers at The University of Texas at Dallas (UTD), led by Dr. Lee Bulla, have demonstrated for the first time the selective cytotoxicity of Bacillus thuringiensis subsp. israelensis Cry4B toxin is mediated by BT-R3.

27 Aug 2013

Researchers discover how common oral bacterium can contribute to colorectal cancer

Researchers from Case Western Reserve University School of Dental Medicine have discovered how a common oral bacterium can contribute to colorectal cancer, a finding that opens promising new research avenues for the development of approaches to prevent and treat the disease.

16 Aug 2013

NCI renews UCLA prostate SPORE grant

UCLA's Jonsson Comprehensive Cancer Center and the department of urology at the David Geffen School of Medicine at UCLA have been notified that their standing as a National Cancer Institute Specialized Program of Research Excellence site in prostate cancer has been renewed for another five years.

8 Aug 2013

TSRI scientists decode important molecular signal that guides development of neocortex

Scientists at The Scripps Research Institute have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex. The largest and most recently evolved region of the brain, the neocortex is particularly well developed in humans and is responsible for sensory processing, long-term memory, reasoning, complex muscle actions, consciousness and other functions.

8 Aug 2013

Scientists identify important molecular signal that guides development of brain

Scientists at The Scripps Research Institute (TSRI) have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex.

8 Aug 2013

Findings open new perspectives for research on proteins that control metastasis

In experiments on zebrafish, Freiburg researchers have demonstrated that the same proteins that lead to the formation of metastases in humans also cause the cells to migrate during embryonic development.

24 Jul 2013

Cadherin News and Research

Study underlines critical role of Fragile X mental retardation protein in brain development

TNF-α key player in RCC progression

Ludwig researchers discover key mechanism that control plasticity of epithelial cells

Researchers discover new function of body's most important tumor-suppressing protein

UCSB study shows that key protein in epithelial cells plays important roles in how cells sense direction

Fourteen businesses receive innovative funding to improve kidney care

Study provides better understanding of intestinal pathologies associated with inherited, infectious diseases

Researchers discover tumor suppressor gene folliculin essential to normal lung function in BHD patients

Researchers discover mechanism that control normal lung function in patients with BHD syndrome

New research links spread of colon cancer to PLAC8 protein

H4 receptor activation plays part in NSCLC progression

Selective FAK inhibition within endothelial cells prevents spontaneous tumor metastasis

Shared genetic risk for bipolar disorder and BMI

Cells sticking molecule over-produced in rheumatoid arthritis and cancers

Study reveals role of cadherin receptor BT-R3 in killing action of Cry4B mosquito toxin

Researchers discover how common oral bacterium can contribute to colorectal cancer

NCI renews UCLA prostate SPORE grant

TSRI scientists decode important molecular signal that guides development of neocortex

Scientists identify important molecular signal that guides development of brain

Findings open new perspectives for research on proteins that control metastasis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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