Carcinogenesis News and Research

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Study shows disrupted micronuclei may prove to be a valuable tool for detecting cancer

Scientists studying cancer development have known about micronuclei for some time. These erratic, small extra nuclei, which contain fragments or whole chromosomes that were not incorporated into daughter cells after cell division, are associated with specific forms of cancer and are predictive of poorer prognosis.

10 Jul 2013

Disrupted micronuclei might play more active role in carcinogenesis, new study finds

9 Jul 2013

Bacterial DNA more likely to integrate in the genome of tumors than in normal healthy cells

Bacterial DNA may integrate into the human genome more readily in tumors than in normal human tissue, according to a new study from the University of Maryland School of Medicine's Institute for Genome Sciences. Researchers analyzed genomic sequencing data available from the Human Genome Project, the 1,000 Genomes Project and The Cancer Genome Atlas (TCGA). They considered the phenomenon of lateral gene transfer (LGT), the transmission of genetic material between organisms in the absence of sex.

21 Jun 2013

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Chlamydia trachomatis is a human pathogen that is the leading cause of bacterial sexually transmitted disease worldwide with more than 90 million new cases of genital infections occurring each year. About 70 percent of women infected with Chlamydia remain asymptomatic and these bacteria can establish chronic infections for months, or even years. Even when it causes no symptoms, Chlamydia can damage a woman's reproductive organs. In addition, standard antibacterial drugs are proving increasingly ineffective in complete eradication, as Chlamydia goes in to persistent mode, leading to asymptomatic chronic infection.

21 Jun 2013

CT scans increase risk of radiation-induced cancer in young children, study finds

According to a study of seven U.S. healthcare systems, the use of computed tomography scans of the head, abdomen/pelvis, chest or spine, in children younger than age 14 more than doubled from 1996 to 2005, and this associated radiation is projected to potentially increase the risk of radiation-induced cancer in these children in the future, according to a study published Online First by JAMA Pediatrics, a JAMA Network publication.

11 Jun 2013

AGA researchers to present exciting data on GI disorders at DDW 2013

Clinicians, researchers and scientists from around the world will gather for Digestive Disease Week- 2013, the largest and most prestigious gastroenterology meeting, from May 18 to 21, 2013, at the Orange County Convention Center in Orlando, FL.

18 May 2013

Antitumor medication from natural origins on the rise

Natural phenolic compounds play an important role in cancer prevention and treatment. Researchers who examine the medicinal herbs and dietary plants that can aid in cancer treatment and prevention have found that antitumor medication from natural origins is on the rise.

9 May 2013

Research findings suggest new treatment for breast, colon, melanoma and other cancers

A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results.

3 May 2013

New screening method detects ovarian cancer by examining neighboring cells

Pioneering biophotonics technology developed at Northwestern University is the first screening method to detect the early presence of ovarian cancer in humans by examining cells easily brushed from the neighboring cervix or uterus, not the ovaries themselves.

23 Apr 2013

Protein with key job in muscle function moonlights in nucleus to help regulate genes

A key building block of life, actin is one of the most abundant and highly conserved proteins in eukaryotic cells.

25 Mar 2013

Research shows THz pulses destroy skin tissue and increase tumor-suppressing proteins

Terahertz (THz) radiation, a slice of the electromagnetic spectrum that occupies the middle ground between microwaves and infrared light, is rapidly finding important uses in medical diagnostics, security, and scientific research. As scientists and engineers find evermore practical uses for this form of radiation, questions persist about its potential human health risks.

15 Mar 2013

Bitter melon juice restricts ability of pancreatic cancer cells to metabolize glucose

A University of Colorado Cancer study published this week in the journal Carcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose, thus cutting the cells' energy source and eventually killing them.

13 Mar 2013

Physical activity has no relation with risk of non-invasive breast cancer

A European study published in the 'Cancer Epidemiology, Biomarkers & Prevention' journal has analysed the association between physical activities and in situ or non-invasive breast cancer, or, in other words, cancer that has not yet invaded cells within or outside of the breast.

1 Mar 2013

Kaposi’s sarcoma risk factors revealed

Scientists have uncovered an intriguing relationship between the risk for Kaposi’s sarcoma, smoking, and the use of highly active antiretroviral therapy.

25 Feb 2013

Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis

Recent studies have identified correlations between cigarette smoke-induced microRNA (miRNA) expression and different aspects of lung cancer; however, it is unclear how miRNA expression directly contributes to carcinogenesis.

16 Feb 2013

IKBKE gene plays a key role in tobacco-induced lung cancer

Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune response.

16 Feb 2013

Milk thistle constituent shows promising skin protection properties

Silibinin, a key component of milk thistle seeds, can help protect against skin damage caused by ultraviolet B radiation, show study findings published in Molecular Carcinogenesis.

8 Feb 2013

Society of Toxicology's 52nd Annual Meeting to be held from Mar. 10-16 in San Antonio

A group of 7,000 scientists working in multiple specialties, from more than 50 countries, will meet March 10-14, 2013 at the Henry B. Gonzalez Convention Center in San Antonio, Texas, to share their latest findings on 60 topical issues of concern to human health and the environment.

7 Feb 2013

Silibinin kills skin cells mutated by UVA radiation and protects against cancer

A pair of University of Colorado Cancer Center studies published this month show that the milk thistle extract, silibinin, kills skin cells mutated by UVA radiation and protects against damage by UVB radiation - thus protecting against UV-induced skin cancer and photo-aging.

31 Jan 2013

UCSD molecular biologist to receive Charles Rodolphe Brupbacher Prize for Cancer Research

Molecular biologist Michael Karin is to receive this year's Charles Rodolphe Brupbacher Prize for Cancer Research in recognition of his studies on the role of chronic inflammation in the development of tumors. The award, which carries CHF 100,000 in prize money, is considered one of the highest accolades for cancer researchers worldwide. The awards ceremony takes place in Zurich this Thursday in the framework of an international symposium on "Breakthroughs in Cancer Research and Therapy".

30 Jan 2013