Carcinoma News and Research

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Carcinoma is cancer that begins in the skin or in tissues that line or cover internal organs.

Interferon alpha and sorafenib combined work better than either alone against kidney cancer

A combination of two drugs works better than either drug alone for patients with renal cell carcinoma, the most common form of kidney cancer, according to a pilot study led by Duke University Comprehensive Cancer Center researchers.

1 Aug 2007

Protein IKKa protects checkpoint gene from chemical shutdown

A protein that is largely absent in one type of skin cancer protects an important gene in a cell's defense against harmful mutations from being silenced, researchers at The University of Texas M. D. Anderson Cancer Center report in the July 20 edition of Molecular Cell.

20 Jul 2007

Researchers identify new combination therapy that promotes cancer cell death

Researchers at the University of Pennsylvania School of Medicine identified a combination therapy as a way to sensitize resistant human cancer cells to a treatment currently being tested in clinical trials They propose that the therapy may help to selectively eliminate cancer cells while leaving healthy cells intact, providing a cancer treatment with fewer side effects.

17 Jul 2007

Co-operation between GSF and clinic improves outlook for sarcoma patients

Hyperthermia, combined with chemotherapy, improves the chances of healing and survival of patients with low-lying, soft tissue sarcomas. At the Annual General Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, the GSF scientist Prof. Dr Rolf D.

16 Jul 2007

Peregrine licenses worldwide rights to a novel anti-angiogenesis technology

Peregrine Pharmaceuticals, Inc. has announced that it has licensed worldwide exclusive rights to a novel anti-angiogenesis technology from The University of Texas M. D. Anderson Cancer Center.

10 Jul 2007

Racial differences in severity of breast cancer presentation confirmed

African-American women are diagnosed with more advanced breast cancer than Caucasians, according to a new, single hospital study.

10 Jul 2007

Why males show a higher rate of inflammation than females in the same diseases

Production of a protein that promotes inflammation appears to be linked to the higher incidence of liver cancer in men than in women, researchers at the University of California, San Diego (UCSD) School of Medicine have determined in mouse studies.

9 Jul 2007

Discovery of method to identify how cancer evades the immune system

One of the fundamental traits of a tumor - how it avoids the immune system - might become its greatest vulnerability, according to researchers from the University of Southern California. Their findings, demonstrated in human breast and colorectal cancers, indicate that a technique for determining a tumor's "immune signature," could be useful for diagnosing and treating specific cancers.

3 Jul 2007

Induction chemotherapy adds to survival rates in lung cancer patients

Patients with inoperable non-small cell lung cancer who receive an initial high dose of chemotherapy before their treatment begins can expect an increase in overall survival, according to a study in the July 1 issue of the International Journal of Radiation Oncology-Biology-Physics, the official journal of ASTRO.

29 Jun 2007

Bayer and Onyx submit supplemental NDA for Nexavar

Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals have announced that a Supplemental New Drug Application (sNDA) for Nexavar (sorafenib) tablets has been submitted to the U.S. Food and Drug Administration (FDA) for the treatment of patients with hepatocellular carcinoma (HCC), the most common form of liver cancer. Nexavar is currently approved in more than 50 countries for the treatment of advanced kidney cancer.

28 Jun 2007

New genetic marker characterizes aggressiveness of cancer cells

Levels of a small non-coding RNA molecule called let-7 appear to define different stages of cancer better than some of the "classical" markers for tumor progression, researchers from the University of Chicago report in the June 25, 2007, early online edition of the Proceedings of the National Academy of Sciences.

26 Jun 2007

Radio Frequency Ablation emerges as an alternative treatment for inoperable liver cancer

Hollywood talent manager Louis Bershad, 68, whose clients include many top actors in town, recently underwent a routine MRI for kidney stones only to learn from his urologist that he also had a tumor in his left kidney.

26 Jun 2007

Scientists show protein accelerates breast cancer progression in animal models

The study is being published in an advanced online edition of the Proceedings of the National Academy of Sciences.

23 Jun 2007

Solvay Pharmaceuticals submits supplemental NDA for AndroGel

Solvay Pharmaceuticals, Inc., has announced that it submitted a supplemental New Drug Application (sNDA) for AndroGel (testosterone gel) 1% CIII to the U.S. Food and Drug Administration (FDA) for treatment in male adolescents ages 13-17 years old with primary or secondary hypogonadism.

17 Jun 2007

Affluent society faces greater risks for skin cancer

Skin cancer levels have shown a significant increase in Northern Ireland since the early 1990s and are more likely to affect men, older people and those living in more affluent areas, according to a study just published in the June issue of British Journal of Dermatology.

15 Jun 2007

A single cancer stem cell is sufficient to initiate and maintain a malignant tumor

At the heart of most, if not all cancers, lie a handful of wayward stem cells that feed the ever growing tumor mass, but their scarcity make it difficult for scientists to study them. Now, times of plenty may lie ahead as a breast cancer cell line , established long ago , turned out to behave a lot like cancer stem cells.

14 Jun 2007

New contributor to aggressive cancers

Mutations in the cell adhesion molecule known as integrin alpha 7 (integrin 7) lead to unchecked tumor cell proliferation and a significantly higher incidence in cancer spread, or metastasis, in several cancer cell lines, report researchers at the University of Pittsburgh School of Medicine in a study published in the Journal of the National Cancer Institute.

8 Jun 2007

New drug-delivery system using nanomaterials

Researchers at UCLA have successfully manipulated nanomaterials to create a new drug-delivery system that promises to solve the challenge of the poor water solubility of today's most promising anticancer drugs and thereby increase their effectiveness.

8 Jun 2007

Results of phase II studies of pazopanib

GlaxoSmithKline (GSK) has announced results from ongoing Phase II studies of pazopanib in advanced or metastatic renal cell carcinoma (RCC) and ovarian cancer.

5 Jun 2007

New drugs to fight colon and breast cancer

A study on epithelial cell lines has allowed for the development of six new drugs to fight colon and breast cancer more effectively than other currently used drugs.

3 Jun 2007