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Recycling tubular endosomes are associated with effective delivery of mRNA-based therapeutics, study finds

A recent study recently demonstrates the endosomal transport of nanoparticle-based formulations for the effective delivery of mRNA-based therapeutics.

14 Dec 2021

CRISPR-Cas enzyme-based diagnostics to detect SARS-CoV-2 infection

A recent review in the journal Life provided a detailed description of CRISPR-Cas-based diagnostic techniques to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but also emphasized the potential use of this technology towards developing effective molecular diagnostic platforms for any future pandemic.

13 Dec 2021

CRISPR/Cas9 gene editing enables sonodynamic therapy to effectively shrink tumors

Sonodynamic therapy uses ultrasound in combination with drugs to release harmful reactive oxygen species (ROS) at the site of a tumor.

8 Dec 2021

Research offers pathway for manufacturing cell cultured meat and breeding enhanced livestock

Scientists have for the first time obtained stem cells from livestock that grow under chemically defined conditions, paving the way for manufacturing cell cultured meat and breeding enhanced livestock.

7 Dec 2021

Researchers use gene-editing to create single sex mice litters

Scientists at the Francis Crick Institute, in collaboration with University of Kent, have used gene editing technology to create female-only and male-only mice litters with 100% efficiency.

6 Dec 2021

Researchers introduce new method for observing cell interactions

Researchers created a system that allows scientists to ‘log’ a cell’s reactions to external stimuli within the cell’s genetic material.

2 Dec 2021

New method can precisely, rapidly correct genetic alterations in patient cells

Researchers in the University of Helsinki and University Hospital Helsinki have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells.

30 Nov 2021

New method helps correct genetic alterations in the cultured patient cells rapidly

Researchers in the University of Helsinki and University Hospital Helsinki have developed a method to precisely and rapidly correct genetic alterations in the cultured patient cells.

30 Nov 2021

New insights on the link between CRISPR, p53 gene and mutated cancer cells

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique.

18 Nov 2021

Study highlights the need for caution while using CRISPR-based gene therapies

A comprehensive study-;conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups-;has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor cells with mutated forms of genes linked to cancer.

11 Nov 2021

New epigenetic editing technique may advance the treatment of many diseases

Type 1 diabetes, rheumatoid arthritis, and cancer are just some of the disorders associated with specific genes not "turning on" and "turning off" as they should.

9 Nov 2021

Scientists create a rapid diagnostic technology to detect SARS-CoV-2

Blending experts from molecular genetics, chemistry and health sciences, researchers at the University of California San Diego have created a rapid diagnostic technology that detects SARS-CoV-2, the coronavirus that causes COVID-19.

6 Nov 2021

Experts gain insights into pathomechanisms of dilated cardiomyopathy

Titin is a "titanically large" protein – the largest in the human body – which enables elastic movements of our muscles, including the heart.

6 Nov 2021

The role of CRISPR in viral diagnostics

A comprehensive review explains in depth how CRISPR can be utilized as a reliable tool to investigate the viral life cycles.

29 Oct 2021

New insight into the tremendously complex "genetic dance"

The rapid scientific advancements that followed the mapping of the human genome have revealed just how staggeringly complex the world of genetics is.

28 Oct 2021

New mouse model shows that it is never too late to treat Hutchinson-Gilford Progeria Syndrome

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III and the Spanish Cardiovascular Research Network (CIBERCV), led by Dr Vicente Andrés, have generated the HGPSrev experimental mouse model.

26 Oct 2021

New method for safe engineering of therapeutic cells with photothermal nanofibers

Professor Braeckmans from Ghent University focused the last ten years on a method for safe engineering of therapeutic cells with photothermal nanofibers.

22 Oct 2021

Researchers uncover how cancer cells use sugar residue to evade the immune system

A team of South Dakota State University chemistry researchers uncovered how cancer cells utilize a simple sugar residue to disguise themselves from the immune system. What they learned will help scientists develop more effective cancer therapeutics.

12 Oct 2021

CRISPR/Cas9-directed epigenetic editing reveals diverse transcriptomic regulation and functional effects

Oncotarget published "Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing" which reported that the adequate functioning of this process is indispensable for tissue homeostasis and cell fate determination.

11 Oct 2021

Study supports efficacy and safety of lung-selective nanotherapy against SARS-CoV-2 infection

A new preprint shows the potential role of a host protease cathepsin L inhibitor, which mediates viral entry into the host cell by its effect on the viral spike protein.

8 Oct 2021