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Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Using the new gene-editing enzyme CRISPR-Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the lab.

13 Apr 2017

Researchers uncover mechanism that leads to disorders in pancreatic development, infant diabetes

Researchers at the University of Helsinki, Finland, have uncovered a mechanism through which a mutation in the STAT3 gene leads to a disorder in the development of the pancreas and to infant diabetes.

11 Apr 2017

Scientists discover promising target to treat highly aggressive brain tumor in infants

Using state-of-the-art gene editing technology, scientists from Ann & Robert H. Lurie Children's Hospital of Chicago have discovered a promising target to treat atypical teratoid/rhabdoid tumor (AT/RT) – a highly aggressive and therapy resistant brain tumor that mostly occurs in infants.

11 Apr 2017

Scientists develop novel technique to screen non-coding DNA of genome for diseases

Researchers have developed a method to swiftly screen the non-coding DNA of the human genome for links to diseases that are driven by changes in gene regulation.

4 Apr 2017

TSRI researchers reveal how viruses incapacitate bacterial defense system

Picture bacteria and viruses locked in an arms race. For many bacteria, one line of defense against viral infection is a sophisticated RNA-guided "immune system" called CRISPR-Cas.

28 Mar 2017

Astrocytes prove to be surprisingly vital players in the body's clock

Until recently, work on biological clocks that dictate daily fluctuations in most body functions, including core body temperature and alertness, focused on neurons, those electrically excitable cells that are the divas of the central nervous system.

25 Mar 2017

Major grant funds research effort that seeks to understand complexity of invasive cancer

A $9.5 million, five-year grant from the National Cancer Institute (NCI) will fund an intensive multidisciplinary research effort that seeks to better understand how cancer cells reach an aggressive state and begin to damage surrounding tissue.

25 Mar 2017

Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

Using a new cellular model, innovative gene therapy approaches for the hereditary immunodeficiency Chronic Granulomatous Disease can be tested faster and cost-effectively in the lab for their efficacy.

21 Mar 2017

Researchers develop new method that uses gene editing to find cancer's weak spots

Genetic mutations that cause cancer also weaken cancer cells, creating an opportunity for researchers to develop drugs that will selectively kill them, while sparing normal cells.

20 Mar 2017

Study findings could lead to novel therapies for preventing vision loss from degenerative retinal diseases

Silencing a gene called Nrl in mice prevents the loss of cells from degenerative diseases of the retina, according to a new study.

15 Mar 2017

Precision NanoSystems launches NanoAssemblr Scale-Up system to support production of novel medicines

Precision NanoSystems has launched the NanoAssemblr™ Scale-Up system to support the clinical development of nanomedicines.

From Precision NanoSystems Inc. 9 Mar 2017

New software tool enables quick, easy deletion of DNA in living cells

Until recently, genomics was a "read-only" science, but scientists have developed a tool for quick and easy deletion of DNA in living cells.

3 Mar 2017

MSK researchers harness power of CRISPR/Cas9 to create more-potent CAR T cells

Researchers from Memorial Sloan Kettering Cancer Center have harnessed the power of CRISPR/Cas9 to create more-potent chimeric antigen receptor (CAR) T cells that enhance tumor rejection in mice.

23 Feb 2017

Scientists engineer smallest CRISPR-Cas9 system to date

Scientists at the Center for Genome Engineering, within the Institute for Basic Science0, in collaboration with KIM Eunji and KIM Jeong Hun have engineered the smallest CRISPR-Cas9 to date, delivered it to the muscle cells and in the eyes of mice via adeno-associated viruses and used it to modify a gene causing blindness.

21 Feb 2017

IBS scientists modify fat content in soybean oil using new CRISPR-Cpf1 technology

A team from the Center for Genome Engineering, within the Institute for Basic Research (IBS), succeeded in editing two genes that contribute to the fat contents of soybean oil using the new CRISPR-Cpf1 technology: an alternative of the more widely used gene editing tool CRISPR-Cas9. The results of this new plant gene editing method, applied to soybeans and wild tobacco genes, are published in Nature Communications.

16 Feb 2017

Cas9 News and Research

Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Researchers uncover mechanism that leads to disorders in pancreatic development, infant diabetes

Scientists discover promising target to treat highly aggressive brain tumor in infants

Scientists develop novel technique to screen non-coding DNA of genome for diseases

TSRI researchers reveal how viruses incapacitate bacterial defense system

Astrocytes prove to be surprisingly vital players in the body's clock

Major grant funds research effort that seeks to understand complexity of invasive cancer

Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

Researchers develop new method that uses gene editing to find cancer's weak spots

Study findings could lead to novel therapies for preventing vision loss from degenerative retinal diseases

Precision NanoSystems launches NanoAssemblr Scale-Up system to support production of novel medicines

New software tool enables quick, easy deletion of DNA in living cells

MSK researchers harness power of CRISPR/Cas9 to create more-potent CAR T cells

Scientists engineer smallest CRISPR-Cas9 system to date

IBS scientists modify fat content in soybean oil using new CRISPR-Cpf1 technology

Yale researchers find potential new way to combat brain cancer

IDT offers cost-effective and most complete spectrum of CRISPR genome editing systems

UT Southwestern scientists discover gene that protects gut from IBD

Scientists develop unique method to fix genes in living organisms

ACMG issues new Points to Consider statement on potential clinical application of genome editing

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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