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Two antagonistic proteins help keep leukemia at bay

Two proteins that scientists once thought carried out the same functions are actually antagonists of each other, and keeping them in balance is key to preventing diseases such as cancer, according to new findings published in the February 25 issue of Developmental Cell by scientists at Fox Chase Cancer Center.

27 Feb 2013

FDA's Oncologic Drugs Advisory Committee to review NDA for tivozanib

AVEO Oncology and Astellas Pharma Global Development, Inc., a U.S. subsidiary of Tokyo-based Astellas Pharma Inc., today announced that the U.S. Food and Drug Administration's Oncologic Drugs Advisory Committee will review the company's New Drug Application for tivozanib for the treatment of patients with advanced renal cell carcinoma during the morning session of its meeting on May 2, 2013.

27 Feb 2013

Ampio Pharmaceuticals starts Optina clinical trial

Ampio Pharmaceuticals, Inc. announced oral dosing of the first patient in a 505(b)(2) clinical trial of the investigational drug Optina in diabetic macular edema.

27 Feb 2013

Researchers discover that tympanic border cells can enable hearing

Researchers at the Stanford University School of Medicine have identified a group of progenitor cells in the inner ear that can become the sensory hair cells and adjacent supporting cells that enable hearing.

27 Feb 2013

New findings could help develop treatments for inherited disorders

Fresh insights into the protective seal that surrounds the DNA of our cells could help develop treatments for inherited muscle, brain, bone and skin disorders.

27 Feb 2013

Two renowned SCCP scientists earn national recognition from Society of Toxicology

Two renowned scientists at the South Carolina College of Pharmacy (SCCP) have garnered national recognition from the Society of Toxicology (SoT), which named them recipients of two of its individual annual awards. It is the first time these awards have gone to individuals from the same College.

27 Feb 2013

Promyleocytic leukemia gene goes up significantly in post treatment of mTOR inhibitors

Glioblastoma, the most common and lethal form of brain tumor in adults, is challenging to treat because the tumors rapidly become resistant to therapy. As cancer researchers are learning more about the causes of tumor cell growth and drug resistance, they are discovering molecular pathways that might lead to new targeted therapies to potentially treat this deadly cancer.

27 Feb 2013

MID1 complex binds with messenger RNA and controls synthesis of defective Huntingtin

Huntington's disease, also known as Huntington's chorea, is a hereditary brain disease causing movement disorders and dementia. In Germany, there are about 8,000 patients affected by Huntington's disease, with several hundred new cases arising every year. The disease usually manifests between the ages of 35 and 50.

27 Feb 2013

UHCC researchers identify role of RSK2 protein in cancer cell migration

Researchers at the University of Hawai'i Cancer Center have uncovered a novel mechanism that may lead to more selective ways to stop cancer cells from spreading. Associate Professor Joe W. Ramos PhD, a cancer biologist at the UH Cancer Center and his team have identified the role of the protein RSK2 in cancer cell migration, part of the process of cancer metastasis.

27 Feb 2013

Genetic variation in CD33 influences how AML patients' leukemic cell responds to GO

Researchers from the College of Pharmacy and Medical School working within the Masonic Cancer Center, University of Minnesota, have partnered to identify genetic variations that may help signal which acute myeloid leukemia (AML) patients will benefit or not benefit from one of the newest antileukemic agents.

26 Feb 2013

Breakthrough study aims at developing first comprehensive model of fetal heart

Technology developed at The University of Nottingham has been used in a breakthrough study aimed at developing the first comprehensive model of a fully functioning fetal heart.

26 Feb 2013

Radial forearm free flap shows worth in mandibular reconstruction

The osteocutaneous radial forearm free flap should be used for mandibular reconstruction because of the low rate of long-term donor and recipient site complications, particularly with prophylactic plating of the donor radius, say US scientists.

26 Feb 2013

Loss of Dickopf-1 restores neurogenesis and memory in animal model

Loss of the molecule Dickopf-1 in the hippocampus in older animals increases neurogenesis, research shows.

26 Feb 2013

Wnt-induced Lgr5 expression marks stem cell production in the liver

For decades scientists around the world have attempted to regenerate primary liver cells known as hepatocytes because of their numerous biomedical applications, including hepatitis research, drug metabolism and toxicity studies, as well as transplantation for cirrhosis and other chronic liver conditions. But no lab in the world has been successful in identifying and growing liver stem cells in culture -- using any available technique - until now.

26 Feb 2013

Researchers improve NanoVelcro device to better grab cancer cells as blood passes by them

Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients' tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.

26 Feb 2013

Study finds major risk factor behind increased risk of adverse outcomes in IVF pregnancies

Massachusetts General Hospital (MGH) researchers have identified what may be a major factor behind the increased risk of two adverse outcomes in pregnancies conceived through in vitro fertilization (IVF).

26 Feb 2013

Recombinant Newcastle disease virus kills all kinds of prostate cancer cells

A recombinant Newcastle disease virus kills all kinds of prostate cancer cells, including hormone resistant cells, but leaves normal cells unscathed, according to a paper published online ahead of print in the Journal of Virology.

26 Feb 2013

Cleveland Clinic receives $1.97M NIMH grant for innovative autism research

The National Institute of Mental Health (NIMH) has awarded $1.97 million for innovative autism research to Bruce Trapp, Ph.D., Chairman of Neurosciences at Cleveland Clinic's Lerner Research Institute.

26 Feb 2013

DHA supplementation during pregnancy reduces very low birth weight and early preterm delivery

University of Kansas researchers have found that the infants of mothers who were given 600 milligrams of the omega-3 fatty acid DHA during pregnancy weighed more at birth and were less likely to be very low birth weight and born before 34 weeks gestation than infants of mothers who were given a placebo. This result greatly strengthens the case for using the dietary supplement during pregnancy.

26 Feb 2013

Experts analyse biological function of Shewanella-like protein phosphatase

Experts have disabled a unique member of the signalling proteins which are essential for the development of the malaria parasite. They have produced a mutant lackingthe ancient bacterial Shewanella-like protein phosphatase known as SHLP1 (pronounced shelph). This mutant is unable to complete its complex life cycle and is arrested in its development in the mosquito.

26 Feb 2013