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Clonal evolution explains unpredictable leukemia disease course

Scientists have revealed the complicated clonal evolution of chronic lymphocytic leukemia, giving insight into the variation in disease course and its response to treatment.

19 Feb 2013

Real-time PCR reproducibility improved by handheld electronic pipette

INTEGRA has reported how a leading US clinical diagnostic laboratory has, using a VIAFLO 96 handheld electronic pipette, significantly improved the reproducibility and productivity with which it carries out Real-time PCR assays.

From INTEGRA Biosciences 19 Feb 2013

Insights into HIV-1 virion makeup could improve gene therapy

A discovery about how the HIV-1 virion packages genomic RNA may help researchers to improve the efficacy of gene therapy.

18 Feb 2013

MILabs VECTor/CT installed by Molecular Imaging Center Antwerp (MICA) in Belgium

MILabs B.V. is pleased to announce that the Molecular Imaging Center Antwerp (MICA) in Belgium has installed a MILabs VECTor/CT to enhance their portfolio of pre-clinical nuclear oncology and neurology imaging and research capabilities.

18 Feb 2013

Study describes pharmacological action of TZDs directly on pancreas

A scientific study published on the journal Diabetes, edited by the American Diabetes Association, describes for the first time the pharmacological action of thiazolidinediones (TZDs) —anti-diabetic drugs— directly on pancreas, the organ which produces insulin.

18 Feb 2013

Article details mechanism by which long non-coding RNA-activators promote gene expression

Long segments of RNA- encoded in our DNA but not translated into protein-are key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some cancers, in adults.

18 Feb 2013

New frontiers in trauma and stroke recovery

Cynthia Thompson, a world-renowned researcher on stroke and brain damage, will discuss her groundbreaking research on aphasia and the neurolinguistic systems it affects Feb. 16 at the annual meeting of the American Association for the Advancement of Science (AAAS). An estimated one million Americans suffer from aphasia, affecting their ability to understand and/or produce spoken and/or written language.

18 Feb 2013

Positive results from Neurim’s Piromelatine phase II study on insomnia

Neurim Pharmaceuticals announced today positive results from a phase II clinical study evaluating the efficacy and safety of Piromelatine (Neu-P11), a novel investigational multimodal sleep medicine developed for the treatment of patients with primary and co-morbid insomnia.

18 Feb 2013

'Innovations in Imaging' symposium at AAAS to explore leading edge of microscopy

When difficult biological questions are tackled by creative experts in physics, what can result? Images of great beauty, accessible for anyone to appreciate, that also offer rich information on fundamental life processes, and rewarding new paths for analysis and insight.

18 Feb 2013

Researchers discover genetic defect that can halt cell growth

A Melbourne-based research team has discovered a genetic defect that can halt cell growth and force cells into a death-evading survival state.

18 Feb 2013

Researchers explore cellular signals produced by the body in response to traumatic injury

When it comes to healing the terrible wounds of war, success may hinge on the first blood clot - the one that begins forming on the battlefield right after an injury. Researchers exploring the complex stream of cellular signals produced by the body in response to a traumatic injury believe the initial response - formation of a blood clot - may control subsequent healing.

18 Feb 2013

Oxidized CaMKII may increase risk of death in diabetics following heart attack

Having diabetes doubles a person's risk of dying after a heart attack, but the reason for the increased risk is not clear. A new University of Iowa study suggests the link may lie in the over-activation of an important heart enzyme, which leads to death of pacemaker cells in the heart, abnormal heart rhythm, and increased risk of sudden death in diabetic mice following a heart attack.

18 Feb 2013

Infrared signaling could create sense of touch in artificial limbs

Rats can't usually see infrared light, but they have "touched" it in a Duke University lab. The rats sensed the light as a sensation of touch after Duke neurobiologist Miguel Nicolelis and his team fitted the animals with an infrared detector wired to electrodes implanted in the part of the mammalian brain that processes information related to the sense of touch.

17 Feb 2013

Two studies discover new enzyme that acts as a sensor of innate immunity

Two studies by researchers at UT Southwestern Medical Center could lead to new treatments for lupus and other autoimmune diseases and strengthen current therapies for viral, bacterial, and parasitic infections.

16 Feb 2013

Parkinson's-related mutations may also affect vision

The most common genetic cause of Parkinson's is not only responsible for the condition's distinctive movement problems but may also affect vision, according to new research by scientists at the University of York.

16 Feb 2013

Researchers identify mechanism through which mitochondria control breast tumor aggressiveness

Doctors currently struggle to determine whether a breast tumor is likely to shift into an aggressive, life-threatening mode-an issue with profound implications for treatment. Now a group from The Scripps Research Institute (TSRI) has identified a mechanism through which mitochondria, the powerhouses of a cell, control tumor aggressiveness.

16 Feb 2013

TSG might be novel compound for treatment of Alzheimer's and dementia with Lewy body

Administration of the active compound tetrahydroxystilbene glucoside (TSG) derived from the Chinese herbal medicine Polygonum multiflorum Thunb, reversed both overexpression of α-synuclein, a small protein found in the brain, and its accumulation using a mouse model of Alzheimer's disease.

16 Feb 2013

Cell News and Research

Clonal evolution explains unpredictable leukemia disease course

Real-time PCR reproducibility improved by handheld electronic pipette

Insights into HIV-1 virion makeup could improve gene therapy

MILabs VECTor/CT installed by Molecular Imaging Center Antwerp (MICA) in Belgium

Study describes pharmacological action of TZDs directly on pancreas

Article details mechanism by which long non-coding RNA-activators promote gene expression

New frontiers in trauma and stroke recovery

Positive results from Neurim’s Piromelatine phase II study on insomnia

'Innovations in Imaging' symposium at AAAS to explore leading edge of microscopy

Researchers discover genetic defect that can halt cell growth

Researchers explore cellular signals produced by the body in response to traumatic injury

Oxidized CaMKII may increase risk of death in diabetics following heart attack

Infrared signaling could create sense of touch in artificial limbs

Two studies discover new enzyme that acts as a sensor of innate immunity

Parkinson's-related mutations may also affect vision

Researchers identify mechanism through which mitochondria control breast tumor aggressiveness

TSG might be novel compound for treatment of Alzheimer's and dementia with Lewy body

Government of Québec announces $10M investment in Personalized Medicine Partnership for Cancer

Patients with untreated depression are poorly protected by shingles vaccination

New approach could make gene therapy dramatically more effective for HIV patients

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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