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Thermo Fisher's expandable portfolio of lab automation solutions to be showcased at SLAS 2013

Thermo Fisher Scientific Inc., the world leader in serving science, today introduced a new range of laboratory automation and screening solutions during the Second Annual Society for Laboratory Automation and Screening (SLAS) conference and exhibition.

From Thermo Fisher Scientific Inc. 16 Jan 2013

p53 activation suppresses malic enzyme expression and leads to senescence in pre-cancerous cells

It is perhaps impossible to overstate the importance of the tumor suppressor gene p53. It is the single most frequently mutated gene in human tumors. p53 keeps pre-cancerous cells in check by causing cells, among other things, to become senescent - aging at the cellular level. Loss of p53 causes cells to ignore the cellular signals that would normally make mutant or damaged cells die or stop growing.

16 Jan 2013

Over-expression of NEK2 in cancer cells significantly enhances drug resistance

Increased NEK2 gene expression linked to increased drug resistance, faster cancer growth, and poorer patient outcome - The finding may improved diagnostic and prognostic tools for cancer care and could lead to improved cancer therapies

16 Jan 2013

Researchers discover molecular blueprint behind the IFIT protein

Researchers at McGill University and the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences have discovered the molecular blueprint behind the IFIT protein.

15 Jan 2013

Aggressive breast cancer’s metastasis molecular switch identified

Scientists at Weill Cornell Medical College have discovered the molecular switch that allows aggressive triple negative breast cancer cells to grow the amoeba-like protrusions they need to crawl away from a primary tumor and metastasize throughout the body. Their findings, published in Cancer Cell, suggest a novel approach for developing agents to treat cancer once it has spread.

15 Jan 2013

New hope for people with sound-induced deafness

Preliminary results from a study in mice suggest it may be possible to regenerate cochlear hair cells that have been damaged due to excessive noise exposure.

15 Jan 2013

Spacemen upset sodium balance theories

Levels of salt in the body and sodium in the urine fluctuate over fixed cycles that are independent of salt intake, shows a space simulation study.

15 Jan 2013

Beta blocker use linked to NSCLC patient survival

Beta blockers may boost survival in patients undergoing definitive radiotherapy for non-small-cell lung cancer, suggests research published in the Annals of Oncology.

14 Jan 2013

Sequencing-based test effectively detects many fetal genetic defects

Researchers have developed a new screening test that allows detection of fetal abnormalities in maternal blood by deep sequencing cell-free DNA extracted from plasma.

14 Jan 2013

Monitor white blood cell count in pertussis infants

Researchers say that taking early and repeat white blood cell counts could help determine which children with pertussis are at highest risk for death.

14 Jan 2013

Human papillomavirus an etiologic factor in 6% of OCSCC cases

High-risk human papillomavirus is an etiologic factor in approximately 6% of cases of oral cavity squamous cell carcinoma, according to epidemiologic research.

14 Jan 2013

Bionic devices: an interview with Dr Rylie Green

Bionic devices are implants which replace biological functions which have been lost due to nerve damage. They use electrical signals to stimulate the remaining nerve cells following disease or injury. Although the term bionic was only coined in the late 1950s, the earliest bionic devices were cardiac pacemakers, developed in the early 1900s. However the first commercial implantable units were not available until the 1950s.

14 Jan 2013

Reviewing the latest methods for characterizing biomaterials

Biomaterials and medical devices must be rigorously tested in the laboratory before they may be implanted into test subjects. By ensuring that these test methods are both quick and efficient, an increased number of materials can be tested and working implants can be produced more rapidly. The development of such tests is therefore essential to biomedical advancement, and Characterization of biomaterials reviews the latest methods for defining properties and characterizing materials. Characterization of biomaterials discusses a wide array of techniques and various unique approaches to the problems faced in characterizing biomaterials, whilst also providing information on standards and methods for assessing the safety and biocompatibility of biomaterials.

14 Jan 2013

Repression of PTB protein in fibroblasts can convert pluripotent stem cells into functional neurons

Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells - abundantly found in connective tissues - into functional neurons. The findings, which could have far-reaching implications for the development of new treatments for neurodegenerative diseases like Huntington's, Parkinson's and Alzheimer's, will be published online in advance of the January 17 issue of the journal Cell.

11 Jan 2013

Baboon embryonic stem cells can be programmed to completely restore severely damaged arteries

Scientists at the Texas Biomedical Research Institute have for the first time demonstrated that baboon embryonic stem cells can be programmed to completely restore a severely damaged artery. These early results show promise for eventually developing stem cell therapies to restore human tissues or organs damaged by age or disease.

11 Jan 2013

Blocking interaction of JNK enzyme may counteract neuron destruction

Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, Amyotrophic Lateral Sclerosis and Parkinson's disease.

11 Jan 2013

Cancer researchers solve mystery of how Chd5 protein exerts its beneficial effects

A team of cancer researchers at Cold Spring Harbor Laboratory (CSHL) has solved the mystery of how one of the most powerful of the body's natural tumor-suppressing proteins, called Chd5, exerts its beneficial effects.

11 Jan 2013

Young humans capable of generating new heart muscle cells

Researchers at Boston Children's Hospital have found, for the first time that young humans (infants, children and adolescents) are capable of generating new heart muscle cells.

11 Jan 2013

Taking early and repeated WBC is critical in determining infants at high risk of pertussis

A study released today from the upcoming issue of the Journal of the Pediatric Infectious Diseases Society (JPIDS) found that taking early and repeated white blood cell counts (WBC) is critical in determining whether infants have pertussis and which of those children are at highest risk of death from the disease.

11 Jan 2013

DESI technique identifies cancer type, grade and tumor margins in brain surgery patients

A new tool that could allow for faster, more comprehensive testing of brain tissue during surgery successfully identified the cancer type, grade and tumor margins in five brain surgery patients, according to a Purdue University and Brigham and Women's Hospital study.

11 Jan 2013