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Researchers use model organism to test new therapies for retinal degeneration

Research by Johns Hopkins sensory biologists studying fruit flies, has revealed a critical step in fly vision. Humans with problems in this same step suffer retinal dystrophies, which manifest as visual defects ranging from mild visual impairments to complete blindness.

16 Feb 2010

Oncolytics Biotech receives U.K. MHRA approval for REOLYSIN combination Phase 3 trial

Oncolytics Biotech Inc. today announced that it has received a letter of approval from the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) to conduct its Phase 3 trial examining REOLYSIN in combination with paclitaxel and carboplatin in patients with platinum-refractory head and neck cancers. This is the same trial that the Company previously reached an agreement on with the U.S. Food and Drug Administration (FDA) under the Special Protocol Assessment (SPA) process.

16 Feb 2010

EntreMed's ENMD-2076 for AML receives FDA's orphan drug designation

EntreMed, Inc., today announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation for the Company's lead oncology drug candidate, ENMD-2076, for the treatment of acute myeloid leukemia (AML).

16 Feb 2010

'Fertility chip' to accurately count spermatozoa in sperm

A new 'fertility chip', developed by researchers at the University of Twente's MESA+ Institute for Nanotechnology, can accurately count spermatozoa in sperm. This is an important step towards the development of a compact device for reliable 'pre-scanning' of male fertility. The researchers are publishing the invention of the chip in the scientific journal Lab on a Chip.

16 Feb 2010

Gallup-Healthways WBI City and State Reports released

Individuals wanting to increase their personal well-being and enjoy the highest quality of life in America might want to consider relocating to Boulder, Colo. or the state of Hawaii.

16 Feb 2010

When blood sugar levels rise in healthy people, insulin signals cells to increase production: Study

In type 2 diabetes, which is occurring at alarming rates, the hormone insulin does not work effectively to lower blood sugars and patients also do not make enough insulin. These two processes have been widely considered as separate.

16 Feb 2010

Scientists discover molecular pathway to regenerate damaged kidney tissues

Scientists have discovered a molecular pathway that works through the immune system to regenerate damaged kidney tissues and may lead to new therapies for repairing injury in a number of organs.

16 Feb 2010

Use of non-steroidal anti-inflammatory drugs not associated with risk of squamous cell skin cancer

Contrary to previous hypotheses, the use of non-steroidal anti-inflammatory drugs does not appear associated with risk of squamous cell skin cancer, according to a report posted online today that will appear in the April print issue of Archives of Dermatology, one of the JAMA/Archives journals.

16 Feb 2010

Clive Svendsen to receive American Academy of Neurology Sheila Essey Award for his research on ALS

Clive Svendsen, Ph.D., director of the Cedars-Sinai Regenerative Medicine Institute, is receiving the American Academy of Neurology Sheila Essey Award for his research on ALS (amyothrophic lateral sclerosis).

16 Feb 2010

Over 96% of SIDS cases due to known risk factors

Sudden Infant Death Syndrome (SIDS) continues to be the third leading cause of infant death, according to the Centers for Disease Control (CDC), despite a decline in SIDS that is associated with a rise in safe-sleep practices for newborns and infants. A new study by Barbara M. Ostfeld, PhD and Thomas Hegyi, MD, professors in the Department of Pediatrics at UMDNJ-Robert Wood Johnson Medical School, has identified that more than 96 percent of infants who died of SIDS were exposed to known risk factors, among them sleeping on their side or stomach, or exposure to tobacco smoke, and that 78 percent of SIDS cases contained multiple risk factors.

16 Feb 2010

Study: Common underlying mechanism causes complex defects in brain development and function

A new study reveals that a common underlying mechanism is shared by a group of previously unrelated disorders which all cause complex defects in brain development and function. Rett syndrome (RTT), Cornelia de Lange syndrome (CdLS) and Alpha-Thalassemia mental Retardation, X-linked syndrome (ATR-X) have each been linked with distinct abnormalities in chromatin, the spools of proteins and DNA that make up chromosomes and control how genetic information is read in a cell.

16 Feb 2010

CNRS-Institut researchers identify 'virulence factor' that inhibits host immune response

Oncogenic retroviruses are a particular family of viruses that can cause some types of cancer. Thierry Heidmann and his colleagues in the CNRS-Institut Gustave Roussy-Université Paris Sud 11 "Rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs" Laboratory have studied these viruses. They have identified a "virulence factor" that inhibits the host immune response and allows the virus to spread throughout the body.

16 Feb 2010

NorTech announces winners of annual Innovation Awards program

NorTech, in partnership with Crain's Cleveland Business, is pleased to announce the winners of its annual Innovation Awards program which honors the achievements of Northeast Ohio's most innovative organizations and leaders.

16 Feb 2010

Children's Hospital of Philadelphia awarded two grants to research into cellular therapies for blood disorders

The new decade may herald an era of cell therapy -- treating human diseases by delivering highly specific beneficial cells. In the wake of an NIH decision late last year permitting federally funded researchers to use new lines of human embryonic stem cells, the door has opened more widely to stem cell research.

16 Feb 2010

Researchers discover chemical compound to combat malaria and bacterial diseases

Researchers report that they have discovered - and now know how to exploit - an unusual chemical reaction mechanism that allows malaria parasites and many disease-causing bacteria to survive. The research team, from the University of Illinois, also has developed the first potent inhibitor of this chemical reaction.

16 Feb 2010

UCSF researchers: B1N1 protein is necessary for heart to contract

UCSF researchers have discovered that a protein called B1N1 is necessary for the heart to contract. The findings, published in the Feb. 16 issue of the open access journal PLoS Biology, shed light not only on what makes a heart beat but also on heart failure, a disease where cardiac cells are no longer able to contract and pump blood through the body.

16 Feb 2010

Researchers discover new mechanism within human cells that constantly protects against disease

Researchers at Oregon Health & Science University have discovered a new mechanism within human cells that constantly protects us against disease. P. Michael Conn, Ph.D., a researcher at the OHSU Oregon National Primate Research Center directed the work. The findings are reported in the Feb. 15 issue of the journal Proceedings of the National Academy of Sciences.

16 Feb 2010

Researchers identify potential therapeutic targets for treatment of neuroblastoma

A team of researchers, led by Patrick Mehlen, at Universit- de Lyon, France, has identified the protein NT-3 and the cell-surface molecule to which it binds (TrkC) as potential therapeutic targets for the treatment of neuroblastoma - the most frequent solid tumor in young children- by studying human neuroblastoma cells in vitro and after xenotransplantation into mice and chicks.

15 Feb 2010

Genous Bio-engineered R stent beneficial for patients not suitable for long term DAPT

OrbusNeich announced that clinical data presented at the Joint Intervention Meeting (JIM) 2010 in Rome provide further evidence that the company's Genous stent could be a treatment of choice for patients not suitable for long term dual antiplatelet therapy. The investigator initiated, 50 patient, multicenter study evaluated the safety of patients receiving only 10 days dual antiplatelet therapy undergoing stenting with the Genous Bio-engineered R stent. The primary endpoint was the absence of stent thrombosis or any occlusion within three months.

15 Feb 2010

ERYtech Pharma announces collaborative research agreement with M. D. Anderson Cancer Center

ERYtech Pharma, a specialty pharma company located in France and in USA (Philadelphia), is pleased to announce a collaborative research agreement in the field of personalized medicine focusing on ERYtech’s flagship product, GRASPA®, which consists of red blood cell-encapsulated L-asparaginase (L-ASP).

15 Feb 2010

Cell News and Research

Researchers use model organism to test new therapies for retinal degeneration

Oncolytics Biotech receives U.K. MHRA approval for REOLYSIN combination Phase 3 trial

EntreMed's ENMD-2076 for AML receives FDA's orphan drug designation

'Fertility chip' to accurately count spermatozoa in sperm

Gallup-Healthways WBI City and State Reports released

When blood sugar levels rise in healthy people, insulin signals cells to increase production: Study

Scientists discover molecular pathway to regenerate damaged kidney tissues

Use of non-steroidal anti-inflammatory drugs not associated with risk of squamous cell skin cancer

Clive Svendsen to receive American Academy of Neurology Sheila Essey Award for his research on ALS

Over 96% of SIDS cases due to known risk factors

Study: Common underlying mechanism causes complex defects in brain development and function

CNRS-Institut researchers identify 'virulence factor' that inhibits host immune response

NorTech announces winners of annual Innovation Awards program

Children's Hospital of Philadelphia awarded two grants to research into cellular therapies for blood disorders

Researchers discover chemical compound to combat malaria and bacterial diseases

UCSF researchers: B1N1 protein is necessary for heart to contract

Researchers discover new mechanism within human cells that constantly protects against disease

Researchers identify potential therapeutic targets for treatment of neuroblastoma

Genous Bio-engineered R stent beneficial for patients not suitable for long term DAPT

ERYtech Pharma announces collaborative research agreement with M. D. Anderson Cancer Center

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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