Cell Death News and Research

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Nanoparticle delivery system delivers cancer-suppressing gene in M. D. Anderson trial

A cancer-suppressing gene has been successfully delivered into the tumors of stage 4 lung cancer patients via an intravenously administered lipid nanoparticle in a phase I clinical trial at The University of Texas M. D. Anderson Cancer Center.

18 Apr 2007

Avalon Pharmaceuticals announces results of AVN944 biomarker study

Avalon Pharmaceuticals has announced the results of an AVN944 biomarker study that utilized Avalon's proprietary AvalonRx technology to identify gene signatures that may be useful for patient stratification.

18 Apr 2007

Clioquinol shows promise in fighting cancer

Researchers from the Barbara Ann Karmanos Cancer Institute in Detroit, MI presented strong evidence today that an antibiotic typically prescribed for Alzheimer's patients could be effective in eventually treating certain types of cancers.

18 Apr 2007

New hope for spinal cord injury sufferers

Spinal cord injury (SCI) is one of the most significant forms of neurotrauma with major economic and social impact.

17 Apr 2007

Researchers induce cell death in leukemia

Researchers from the Virginia Commonwealth University Massey Cancer Center presented preclinical research at the American Association of Cancer Research's annual meeting suggesting the potential of a new combination treatment for chronic lymphocytic leukemia (CLL).

17 Apr 2007

Biomira selects PX-866 as clinical development candidate

Biomira Inc. has announced that it has selected PX-866 as its next clinical development candidate.

17 Apr 2007

Snake venom toxin as a treatment for prostate cancer

This certainly sounds unusual, but Dr. Son and colleagues report on the effectiveness of the snake venom toxin (SVT) Vipera lebetina turanica in the inhibition of androgen-independent prostate cancer (AICAP) in the February 2007 issue of Molecular Cancer Therapeutics .

16 Apr 2007

New genetic risk factors for Crohn's disease

An international research team , including investigators from Massachusetts General Hospital (MGH) and the Broad Institute of Harvard University and Massachusetts Institute of Technology, has identified several novel genetic variations associated with the risk of Crohn's disease.

16 Apr 2007

Lactate instead of glucose after traumatic brain injury

The chemical lactate has gotten a bad rap. Conventional wisdom considered it to be little more than the bane of runners and other athletes, causing stiff muscles and fatigue, and the "sour" in sour milk. It turns out that view may have been too narrow.

15 Apr 2007

Dysfunctional DNA repair pathways

Individuals who inherit two mutant copies of any one of about 12 genes that make the proteins of the Fanconi Anemia (FA) pathway develop FA, which is characterized by increased incidence of cancer and bone marrow failure, among other things.

15 Apr 2007

Emotional stress may contribute to development of cancer and may also reduce effectiveness of treatments

Scientists from Wake Forest University School of Medicine are the first to report that the stress hormone epinephrine causes changes in prostate and breast cancer cells that may make them resistant to cell death.

11 Apr 2007

Gene finding could lead to new pathways for development of Alzheimer's therapeutics

Scientists have known for more than a decade that individuals with a certain gene are at higher risk for developing Alzheimer's disease.

11 Apr 2007

Study provides first direct link between plants and humans

The study was published in an advance online edition of the Proceedings of the National Academy of Sciences during the week of April 9, 2007.

10 Apr 2007

Researchers discover enzyme that is a natural tumor suppressor

Building on their 2005 discovery of an enzyme that is a natural tumor suppressor, researchers at the University of California, San Diego (UCSD) School of Medicine have now identified two variants of that enzyme which could provide new targets for therapies to treat diabetes, heart and neurological disease.

10 Apr 2007

Scientists identify protein key to breast cancer spread

(PHILADELPHIA) Researchers at the Kimmel Cancer Center at Jefferson have identified a protein that they say is key to helping a quarter of all breast cancers spread.

10 Apr 2007

Immunological catch-22 with chronic infections

After a viral infection, a small percentage of the T cells generated to kill virus-infected cells remain on guard to establish long-term immunity.

10 Apr 2007

New regulatory mechanism for critical protein signaling domain

The study is being published in Science Express, an advanced online edition of the journal Science, on April 5. It will appear in the print version of Science later this spring.

7 Apr 2007

New and improved techniques to treat cardiac arrest

Professor of Emergency Medicine at the University of Pennsylvania School of Medicine, has been named Director of Penn's new Center for Resuscitation Science.

4 Apr 2007

Heart muscle cell death is an active and ongoing process in heart failure

Using a nuclear medicine technique and molecular imaging to "see" programmed cell loss, the body's normal way of getting rid of unneeded or abnormal cells, may help in early identification of those individuals who are at risk of developing heart failure, say researchers in the April Journal of Nuclear Medicine.

3 Apr 2007