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Emerging cancer therapies and novel targets

What are the cancer drugs of tomorrow and how will they be developed? At the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, researchers will present some answers to these and other pressing questions regarding emerging cancer therapeutics.

25 Oct 2007

piRNAs play an important role in controlling gene function

A study by researchers at the Yale Stem Cell Center for the first time demonstrates that piRNAs, a recently discovered class of tiny RNAs, play an important role in controlling gene function, it was reported this week in Nature.

25 Oct 2007

New target for Hepatocellular carcinoma therapy

Hepatocellular carcinoma (HCC) is a major health problem worldwide. Currently, the only chance for obtaining a cure in patients with HCC is by either a surgical resection or liver transplantation.

25 Oct 2007

Combination targets offer new hope in fight against cancer

While some targeted therapies - drugs developed to attack specific molecules in the critical chemical pathways occurring within cancer cells - work well by themselves, increasingly researchers are finding that they work better when teamed with other targeted and conventional therapies.

24 Oct 2007

Potent inhibitor of Kinesin CENP-E demonstrates tumor cell inhibition

A first-in-class, targeted investigational therapy specifically designed to inhibit a single protein that functions only during cell division shows potent activity in a broad range of cancer cell lines, say researchers from GlaxoSmithKline.

24 Oct 2007

Experimental cancer pharmaceuticals under trial

A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A) demonstrates a novel mechanism of inhibiting tumor cell proliferation and shows activity against a broad panel of human tumor cell lines in vitro: Abstract A 111.

24 Oct 2007

FDA approves approved Ixempra (ixabepilone) for advanced breast cancer

The U.S. Food and Drug Administration has approved Ixempra (ixabepilone), a new anti-cancer treatment, for use in patients with metastatic or locally advanced breast cancer who have not responded to certain other cancer drugs.

22 Oct 2007

Bacteria use plant defence for genetic modification

Bacteria that cause tumours in plants modify plant genomes by skilfully exploiting the plants' first line of defence.

22 Oct 2007

Transgenics sped up

A new method of constructing artificial plant chromosomes from small rings of naturally occurring plant DNA can be used to transport multiple genes at once into embryonic plants where they are expressed, duplicated as plant cells divide, and passed on to the next generation -- a long-term goal for those interested in improving agricultural productivity.

19 Oct 2007

Researcher identify specific cell that causes eye cancer, disproving long-held theory

Investigators at St. Jude Children's Research Hospital have identified the cell that gives rise to the eye cancer retinoblastoma, disproving a long-standing principle of nerve growth and development.

19 Oct 2007

Proteins that underlie cancer

A University of Arkansas scientist who studies constructs of a protein that are associated with the cell transformation that causes cancer has received a five-year, $661,018 grant from the National Institutes of Health to expand his research.

17 Oct 2007

A fresh perspective to the study of cell activity

In process that is shrouded in mystery, rod-shaped bacteria reproduce by splitting themselves in two. By applying advanced mathematics to laboratory data, a team led by Johns Hopkins researchers has solved a small but important part of this reproductive puzzle.

12 Oct 2007

Network approach finds potential breast cancer susceptibility gene

Like a crossword-puzzle solver who uses the letters in some answers to figure out others, researchers at Dana-Farber Cancer Institute and an international group of collaborators have used data on genes involved in inherited forms of breast cancer to identify a gene linked to non-hereditary cases of the disease.

10 Oct 2007

Gene may hold key to future cancer hope

Scientists may have discovered a new way of killing tumours in what they hope could one day lead to alternative forms of cancer treatments.

From The University of Manchester 9 Oct 2007

HMMR gene emerges as a key player in breast cancer

Researchers in a multicenter international study have identified a new gene that, if mutated, may increase a woman's risk of breast cancer by more than a third.

8 Oct 2007

Ground-breaking techniques to study telomeres in human cells may lead to early cancer detection

A test to detect the very early stages of cancer could one day result from new research by Cardiff University scientists.

4 Oct 2007

Worm study sheds light on how the human body ages

Microscopic worms used for scientific research are living longer despite cellular defects, a discovery that is shedding light on how the human body ages and how doctors could one day limit or reverse genetic mutations that cause inherited diseases, according to a new University of Colorado at Boulder study.

2 Oct 2007

Defining biomarkers for better colon cancer treatment

Barcelona, Spain: New research has yielded a clearer picture of which biomarkers could help doctors more precisely target the treatment of colon cancer, bringing closer the day when patients who will not benefit from chemotherapy are spared it, while those that will, get the more aggressive treatment they need.

27 Sep 2007

Axitinib shows promise for patients with advanced kidney cancer

Barcelona, Spain: A new drug has shown promise in patients with advanced kidney cancer whose options run out after their tumour fails to respond to the cutting edge therapy.

27 Sep 2007

BRCA1 gene plays significant role in non-small cell lung cancer

Barcelona, Spain: Researchers have found that the breast cancer susceptibility gene, BRCA1, plays a significant role in non-small cell lung cancer (NSCLC).

25 Sep 2007