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Metastatic Melanoma: key protein identified that aids the spread of skin cancer

In this interview, News-Medical spoke to Dr. Jeremy Carlton and Professor Victoria Sanz-Moreno about their latest research into the spread of skin cancer.

20 Jan 2023

Mutations may underlie how the most aggressive lymphomas arise and resist therapies

The key to understanding how the most aggressive lymphomas arise and resist current therapies may lie in mutations that disrupt a critical natural selection process among antibody-producing B cells, according to a multi-institutional preclinical study led by Weill Cornell Medicine investigators.

19 Jan 2023

Altering a cellular process can lead stem cells to die or regenerate, study finds

A new study led by Cedars-Sinai and the University of California, San Francisco (UCSF), has determined that altering a cellular process can lead stem cells-;cells from which other cells in the body develop-;to die or regenerate.

13 Jan 2023

Comprehensive atlas of protein kinases could help scientists decipher many cellular signaling pathways

One of the most important classes of human enzymes are protein kinases -; signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism.

12 Jan 2023

Unique mass spectrometry-based approach to study specific changes in DNA after replication

A new method to study specific changes in DNA after replication has been published as a technical report in Nature Cell Biology.

12 Jan 2023

MALAT1 suppression is a hallmark of tissue and peripheral proliferative T cells in COVID-19

In a recent study posted to the medRxiv* preprint server, researchers in the United Kingdom investigated lncRNA (long non-coding ribonucleic acids) expression in coronavirus disease 2019 (COVID-19) T lymphocyte transcriptomes.

10 Jan 2023

Ceramides start to accumulate in muscle during aging, finds study

A study carried out at the University of Helsinki and école Polytechnique Fédérale de Lausanne in Switzerland found that during aging, ceramides, a class of fat molecules called sphingolipids, start to accumulate in muscle, impairing its function.

10 Jan 2023

An updated framework for understanding the biology of the bacterial system

Nobody wants to be average. But for a long time, scientists have found it convenient to think of bacterial cells as just that: "average."

9 Jan 2023

Antibiotic perseverance increases the risk of antibiotic resistance development

Bacterial perseverance is a new phenomenon that helps explain how bacteria adapt to survive antibiotic treatments.

4 Jan 2023

Researchers identify novel gene mechanism in most aggressive kidney cancers

In a new study from the Johns Hopkins Kimmel Cancer Center, researchers described a novel mechanism of tumor formation in kidney cancers driven by overexpression of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway with loss of the tuberous sclerosis complex (TSC) tumor suppressor gene.

3 Jan 2023

Researchers use engineered proteins to record histories of cellular events

As cells perform their everyday functions, they turn on a variety of genes and cellular pathways. MIT engineers have now coaxed cells to inscribe the history of these events in a long protein chain that can be imaged using a light microscope.

2 Jan 2023

New mathematical model for the motion of bacteria

Biofilms form when microorganisms such as certain types of bacteria adhere to the surface of objects in a moist environment and begin to reproduce resulting in the excretion of a slimy glue-like substance.

28 Dec 2022

Smart molecular glue ensures the nucleus is correctly positioned for cell division

Researchers from Paul Scherrer Institute PSI and ETH Zurich have discovered how proteins in the cell can form tiny liquid droplets that act as a smart molecular glue.

19 Dec 2022

Researchers identify a small number of 'cheating' cancer cells under hypoxia

Researchers at UConn Health, Yale, and Johns Hopkins have identified that some cancer cells can "cheat" through escaping constraints imposed by lack of oxygen, allowing the cancer cells to continue to grow.

16 Dec 2022

Landmark study challenges a 70-year-old theory of protein folding

A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system.

9 Dec 2022

Collaborative work unravels hidden molecular secrets of age-related diseases

Insilico Medicine, a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, and the University of Copenhagen announced today the release of the first batch of results from the collaborative work directed to perform multi-omics-based analyses in the context of age-related diseases using an AI-driven target and drug discovery pipeline.

2 Dec 2022

The effect of evolutionary changes in prolonged SARS-CoV-2 infection in an immunosuppressed individual due to advanced HIV

Researchers assessed the impact of SARS-CoV-2 infection on cell death and fusion in an immunocompromised host.

30 Nov 2022

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs.

23 Nov 2022

Discovery could lead to new mantle cell lymphoma drugs

A form of blood cancer known as mantle cell lymphoma is critically dependent on a protein that coordinates gene expression, such that blocking its activity with an experimental drug dramatically slows the growth of this lymphoma in preclinical tests, according to a study from Weill Cornell Medicine researchers.

22 Nov 2022

MIT researchers develop new technique for genome-wide studies of the liver

The liver’s ability to regenerate itself is legendary. Even if more than 70 percent of the organ is removed, the remaining tissue can regrow an entire new liver.

21 Nov 2022