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Duke researchers develop new cell-based drug screening test for dystonia

Duke University researchers have identified a common mechanism underlying separate forms of dystonia, a family of brain disorders that cause involuntary, debilitating and often painful movements, including twists and turns of different parts of the body.

8 Dec 2016

Researchers engineer cells with 'built-in genetic circuit' that can inhibit tumour growth

Researchers at the University of Southampton have engineered cells with a 'built-in genetic circuit' that produces a molecule that inhibits the ability of tumours to survive and grow in their low oxygen environment.

24 Nov 2016

Problems with nuclear membrane play role in leukemia, heart disease and aging disorders

We put things into a container to keep them organized and safe. In cells, the nucleus has a similar role: keeping DNA protected and intact within an enveloping membrane.

2 Nov 2016

Nova Bioprofile FLEX autosampler helps achieve significant productivity improvement via dynamic feeding media optimization

Current industry practices for large-scale mammalian cell cultures typically employ a standard platform fed-batch process with fixed volume bolus feeding. Although widely used, these processes are unable to respond to actual nutrient consumption demands from the culture, which can result in accumulation of by-products and depletion of certain nutrients.

31 Oct 2016

Researchers identify existing drugs that appear to prevent aggressive subtype of pediatric brain tumors

More than 4,000 children and teens are diagnosed with brain cancer each year and the disease kills more children than any other cancer.

27 Oct 2016

Cedars-Sinai receives FDA approval to examine safety of combination stem cell-gene therapy in ALS patients

Cedars-Sinai regenerative medicine investigators have received approval from the U.S. Food and Drug Administration to test a combination stem cell-gene therapy they developed to stall the progression of amyotrophic lateral sclerosis, a neurological disease that causes progressive paralysis and ultimately death.

21 Oct 2016

Cancer cell's shape may offer clues for precise prognosis

Doctors can sometimes use a cancer cell's genetics to predict how it will act - how dangerous it is and thus what treatments should be used against it.

20 Oct 2016

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Domain Therapeutics, a biopharmaceutical company that specializes in the discovery and development of G protein-coupled receptor (GPCR) drugs, today announces the creation of Mavalon Therapeutics, a company focused on stopping the progression of Parkinson’s disease.

19 Oct 2016

Novel microwave-induced photodynamic therapy could target deeply situated tumors

Physicists at The University of Texas at Arlington have shown that using microwaves to activate photosensitive nanoparticles produces tissue-heating effects that ultimately lead to cell death within solid tumors.

12 Oct 2016

New image analysis technique helps better identify and distinguish between two cancer cell types

Brown University researchers have developed a new image analysis technique to distinguish two key cancer cell types associated with tumor progression.

12 Oct 2016

HDAC inhibitors show potential to eliminate breast and ovarian cancer stem cells

A group of researchers, led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has shown that histone deacetylase (HDAC) inhibitors have the potential to eliminate stubborn reservoirs of breast and ovarian cancer stem cells (CSCs).

4 Oct 2016

Researchers move one step closer to unraveling mechanism of multiple-gene disorder

Scientists at Johns Hopkins say they are one step closer to understanding the genetic mechanism of a rare, complex, multiple-gene disorder called Hirschsprung's disease.

30 Sep 2016

New four-stranded version of DNA may hold key to development of targeted cancer therapies

Scientists have identified where a four-stranded version of DNA exists within the genome of human cells, and suggest that it may hold a key to developing new, targeted therapies for cancer.

13 Sep 2016

Penn researchers develop open-source software to infer evolutionary track of tumor metastasis

Individual cells within a tumor are not all the same. This may sound like a modern medical truism, but it wasn't very long ago that oncologists assumed that taking a single biopsy from a patient's tumor would be an accurate reflection of the physiological and genetic make-up of the entire mass.

9 Sep 2016

Triptolide molecule can turn into 'cruise missile' against cancer

More than 20 years ago, a billboard in China piqued the interest of a chemical biologist. It endorsed an extract from the plant known as the “thunder god vine” as an immunosuppressant.

9 Sep 2016

Studying mutant peptides may help detect weaknesses in tumor cells

Researchers from MIPT, the Institute of Biomedical Chemistry, the Institute for Energy Problems of Chemical Physics, and the Research Institute of Physico-Chemical Medicine have presented an algorithm to detect mutant proteins based on mass spectrometry data and the results of exome sequencing.

29 Aug 2016

Cell Line News and Research

Duke researchers develop new cell-based drug screening test for dystonia

Researchers engineer cells with 'built-in genetic circuit' that can inhibit tumour growth

Problems with nuclear membrane play role in leukemia, heart disease and aging disorders

Nova Bioprofile FLEX autosampler helps achieve significant productivity improvement via dynamic feeding media optimization

Researchers identify existing drugs that appear to prevent aggressive subtype of pediatric brain tumors

Cedars-Sinai receives FDA approval to examine safety of combination stem cell-gene therapy in ALS patients

Cancer cell's shape may offer clues for precise prognosis

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Novel microwave-induced photodynamic therapy could target deeply situated tumors

New image analysis technique helps better identify and distinguish between two cancer cell types

HDAC inhibitors show potential to eliminate breast and ovarian cancer stem cells

Researchers move one step closer to unraveling mechanism of multiple-gene disorder

New four-stranded version of DNA may hold key to development of targeted cancer therapies

Penn researchers develop open-source software to infer evolutionary track of tumor metastasis

Triptolide molecule can turn into 'cruise missile' against cancer

Studying mutant peptides may help detect weaknesses in tumor cells

New research may explain why people with blood group O get more severely ill from cholera

Scientists find way to boost efficiency with which CRISPR-Cas9 cuts and disables genes

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

Scientists develop model using transformed stem cells to accelerate screening of drugs for rare cancers

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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