Cell Membrane News and Research

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Cisplatin nanoliposomes for cancer therapy

Cisplatin is one of the most powerful and effective drugs for treating a wide variety of cancers, but many tumors develop resistance to this drug, ultimately limiting its benefits for cancer patients.

19 Sep 2006

Targeted magnetic nanoparticles may be useful in both detecting and treating metastatic breast cancer

An in-depth study of nanoparticle distribution in tumor-bearing mice has shown that targeted magnetic nanoparticles accumulate and cluster in both primary breast tumors and metastatic lesions that have developed in the lung.

21 Aug 2006

Researchers find precise location where an antibody binds to the West Nile virus

Researchers have learned the precise location where an antibody binds to the West Nile virus, and they have suggested a mechanism for how this antibody neutralizes the virus to prevent infection.

14 Aug 2006

New tool to study protein kinase A - linked to heart failure

Scientists studying heart cells have devised a new way to visualize and quantify the rise and fall in the activity of a key enzyme linked to heart failure.

8 Aug 2006

Researchers discover one of the malaria parasite's sneakiest tricks

Researchers have discovered one of the malaria parasite's sneakiest tricks--using dead liver cells to cloak and transport itself back into the bloodstream after leaving the liver.

4 Aug 2006

Diblock copolymer micellar nanoparticles decorated with annexin-A5 proteins

One of the banes of modern cancer therapy is that clinicians and patients must often wait months before they can tell if a given treatment is working.

17 Jul 2006

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells

Various types of carbon-based nanomaterials, such as buckyballs and nanotubes, have shown promise as drug delivery tools and imaging agents, but reports of toxicity associated with some of these materials have raised questions about their ultimate utility in clinical oncology.

10 Jul 2006

Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates

Using a synthetic peptide modeled after the protein that the human immunodeficiency virus (HIV) uses to enter cells, a multi-institutional research team has created quantum dots that can penetrate the cell membrane and image internal structures in a cell.

10 Jul 2006

New findings on cystic fibrosis-related diabetes

A growing number of cystic fibrosis patients are battling a second, often deadly complication: a unique form of diabetes that shares characteristics of the type 1 and type 2 versions that strike many Americans.

10 Jul 2006

New polymer-lipid hybrid nanoparticle

A novel combination of lipids, a negatively charged polymer, and the anticancer drug doxorubicin has yielded a new nanoparticle that can kill breast cancer cells that are normally resistant to this drug.

3 Jul 2006

Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles

Many types of nanoparticles can cross the cell membrane and deliver their therapeutic payload into tumor cells.

3 Jul 2006

Discovery of gene behind iron accumulation in brain has implications for Parkinson's, Alzheimer's

Oregon Health & Science University researchers have identified the gene behind a group of rare, progressive childhood disorders caused by an abnormal buildup of iron in the brain.

18 Jun 2006

Research explains how pathogenic bacteria evolved over millions of years

Bacteria like Salmonella have a complicated immune system that helps them recognize and isolate foreign DNA trying to invade their cell membrane, according to a University of Washington-led study in the June 8 issue of Science Express.

9 Jun 2006

Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose

One of the body's basic survival mechanisms is the neural machinery that triggers the hungry brain to the alertness needed for seeking food.

From The University of Manchester 7 Jun 2006

Study reveals structure of E. coli multidrug transporter protein

This new study could potentially help researchers find new ways to avoid the problem of multidrug resistance and enhance the potency of existing drug compounds.

9 May 2006

Inflammation markers identify fatigue in breast cancer survivors

Researchers at the University of California, Los Angeles have defined conditions associated with disabling fatigue that persists for years in almost a third of breast cancer survivors, according to a study in the May 1 issue of Clinical Cancer Research.

3 May 2006

New method found showing how nerve cells can selectively filter and transfer signals

Scientists from Gvttingen and Bochum find evidence for a new mechanism, with which our nerve cells are able to filter signals and transfer them selectively.

28 Apr 2006

Study indicates how drug efficacy can be increased by manipulating the signalling mechanism

Researchers believe they have found a way to change the action of 60 percent of currently available medications, in some cases making them many times more effective, according to an article published in the April 21 edition of the journal Science. The discovery has the potential to improve treatments for diseases including heart disease, cancer, diabetes, depression and arthritis. The study describes a new way to manipulate perhaps the most important signaling mechanism in human cells: G-protein coupled receptors (GPCRs).

28 Apr 2006

Protein made by cancer virus explains how the virus spreads

New research shows that a protein made by a cancer virus causes infected immune cells to cling to other immune cells, enabling the virus to spread.

26 Apr 2006

New technique to speed discovery of drug targets in chemical genetics

Researchers at Fox Chase Cancer Center have developed a new technique to speed discovery of drug targets in chemical genetics. Fox Chase researcher Jeffrey R. Peterson, Ph.D., and his colleagues describe a new way to swiftly find the proteins targeted by small molecule inhibitors during high-throughput screening (HTS) experiments. The new work offers a critical solution to a common stumbling block in this booming field of drug discovery.

26 Apr 2006

Cell Membrane News and Research

Cisplatin nanoliposomes for cancer therapy

Targeted magnetic nanoparticles may be useful in both detecting and treating metastatic breast cancer

Researchers find precise location where an antibody binds to the West Nile virus

New tool to study protein kinase A - linked to heart failure

Researchers discover one of the malaria parasite's sneakiest tricks

Diblock copolymer micellar nanoparticles decorated with annexin-A5 proteins

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells

Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates

New findings on cystic fibrosis-related diabetes

New polymer-lipid hybrid nanoparticle

Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles

Discovery of gene behind iron accumulation in brain has implications for Parkinson's, Alzheimer's

Research explains how pathogenic bacteria evolved over millions of years

Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose

Study reveals structure of E. coli multidrug transporter protein

Inflammation markers identify fatigue in breast cancer survivors

New method found showing how nerve cells can selectively filter and transfer signals

Study indicates how drug efficacy can be increased by manipulating the signalling mechanism

Protein made by cancer virus explains how the virus spreads

New technique to speed discovery of drug targets in chemical genetics

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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